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Patricia Yuste-Checa

@pyustecheca.bsky.social

Molecular biologist interested in proteostasis and neurodegeneration | Postdoc at Max Planck Institute Biochemistry

7 Posts113 Follower376 Folgt
Patricia Yuste-Checa@pyustecheca.bsky.social · 2mo ago

🦠What if viruses could act as "vehicles" for toxic brain proteins in neurodegenerative diseases? Our new preprint shows that lentiviral particles efficiently package and transmit seeding-competent tau in a cellular model, providing insights into how viral infections may drive neurodegeneration.

Virus-mediated tau aggregate seeding in a cellular model

Formation of neuronal tau protein aggregates is a defining feature of tauopathies, including Alzheimer’s disease and frontotemporal dementia. Tau pathology propagates across brain regions by a cell-to...

biorxiv.org

Patricia Yuste-Checa@pyustecheca.bsky.social · last yr.

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ! #proteostasis #apolipoprotein rdcu.be/ezRLv

Structural analyses define the molecular basis of clusterin chaperone function

Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...

rdcu.be

Nature Structural & Molecular Biology@natsmb.nature.com · last yr.

New online: Structural analyses define the molecular basis of clusterin chaperone function

Structural analyses define the molecular basis of clusterin chaperone function

Nature Structural & Molecular Biology, Published online: 08 August 2025; doi:10.1038/s41594-025-01631-4The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.

go.nature.com