Congratulations to Ellen Zhong, Princeton University, for receiving the 2026 K.H. Kuo Award for Outstanding Young Scientist in Structural Biology www.bsc.org.cn/KuoSymposium...
@qiangguo.bsky.social
Congratulations to Chris Russo, MRC Laboratory of Molecular Biology, for receiving the 2026 K.H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy www.bsc.org.cn/KuoSymposium...
Take a look at the fantastic lineup of speakers we have assembled for the 2026 Kuo Symposium in Beijing! The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available. See you in Beijing! www.bsc.org.cn/KuoSymposium...
4/ We propose that this conserved architecture reveals a strategy for metabolic compartmentalization that couples efficient catalysis with increased molecular robustness.
@qiangguo.bsky.social · 4mo ago3/ Structure-guided perturbation abolishes the assembly in vivo without measurably altering intrinsic catalytic activity, suggesting that the main role of the assembly is spatial organization rather than allosteric regulation.
3/ Structure-guided perturbation abolishes the assembly in vivo without measurably altering intrinsic catalytic activity, suggesting that the main role of the assembly is spatial organization rather than allosteric regulation.
@qiangguo.bsky.social · 4mo ago2/ Urate oxidase homotetramers assemble into helical fibers that laterally tile into a stable, porous lamellar scaffold. This organization preserves accessible surface area while allowing substrate and product exchange.
2/ Urate oxidase homotetramers assemble into helical fibers that laterally tile into a stable, porous lamellar scaffold. This organization preserves accessible surface area while allowing substrate and product exchange.
@qiangguo.bsky.social · 4mo agoPreprint with new server~ Using in situ cryo-ET, we identify a previously uncharacterized higher-order architecture of urate oxidase in mouse liver. langtaosha.org.cn/lts/en/prepr...
Preprint with new server~ Using in situ cryo-ET, we identify a previously uncharacterized higher-order architecture of urate oxidase in mouse liver. langtaosha.org.cn/lts/en/prepr...
A conserved helix-tiling architecture of urate oxidase organizes metabolism in peroxisomes
Cells organize metabolism within a crowded intracellular milieu, yet the structural logic and functional consequences of supramolecular enzyme assemblies in vivo remain poorly defined. Here, using in
langtaosha.org.cn
It is exciting to see closely related biology highlighted in a recent Science paper as well, underscoring the importance of this field. science.org/doi/10.1126/...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...
science.org
@qiangguo.bsky.social · 4mo agoThe peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...
The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...
rRNA expansion segments mediate ribosome dimerization as a conserved stress response
Abstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud
doi.org
@qiangguo.bsky.social · 5mo agoExcited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...
Excited to share what we uncovered using in-tissue cryo-ET in mouse liver: a structural snapshot of lipid droplet biogenesis in situ. Timely reading—particularly after a lipid-rich Chinese New Year😂 The lipid homeostasis story governed by CLCC1 with more details here: www.nature.com/articles/s41...
CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis - Nature
Phospholipid scrambling at the endoplasmic reticulum is essential for establishing a dynamic equilibrium to maintain cellular homeostasis.
nature.com
Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...
biorxiv.org
How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...
Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response - Cellular & Molecular Immunology
Cellular & Molecular Immunology - Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response
nature.com
Really excellent work by the bluesky-less Marie and Sara +coauthors in our lab @embl.org! Check it out for cool combinations of light microscopy and #cryoET, and if you're interested in how yeasts reorganize structurally in response to stressors. #teamtomo
bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 7mo agoStructural reorganization underlying stress-induced cytoplasmicsolidification in yeast https://www.biorxiv.org/content/10.64898/2025.12.22.696049v1
We usually learn that centrioles/basal bodies are made of microtubule triplets. But our work on Plasmodium shows its basal body is built from singlets, which then mature into the doublets of a functional cilium. #TEAMTOMO www.nature.com/articles/s41...
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis - Nature Communications
Yang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in thi...
nature.com
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
science.org
Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀
Institute of Science and Technology Austria (ISTA)@istaresearch.bsky.social · 11mo agoCryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left. On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
