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Da-Neng Wang

@danengw.bsky.social

Structural biologist, professor, NYU School of Medicine. Alum of: Skirball Institute, EMBL-Heidelberg, Univ Stockholm, Acad Sin, NEU. Personal account. https://scholar.google.com/citations?user=lX2sB0sAAAAJ&hl=en

32 Posts291 Follower195 Folgt
Carl T. Bergstrom@carlbergstrom.com · 2w ago

Trump is going after the National Academy of Sciences. Gift link.

Trump Attacks National Academies Over Climate Chapter in Judges’ Manual (Gift Article)

The president joined Republican officials who slammed the National Academies of Sciences for a chapter about climate science in an educational guide for judges.

nytimes.com

Nigel Goldenfeld@nigelgoldenfeld.bsky.social · 2w ago

🧪 #climate Trump has ordered a probe of the National Academy of Sciences. If the timing on his post is Eastern Time, and he actually types his posts himself, then I guess this was on his mind during the World Cup final.

David B. Sauer@davidbsauer.bsky.social · 3w ago

A water molecule is crucial to maintaining the structure and transport activity of VcINDY! academic.oup.com/pnasnexus/ad... Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)

Functional role of a structural water in the elevator domain of dicarboxylate transporter VcINDY

Abstract. The divalent anion sodium symporter (DASS) family mediates the uptake of Krebs cycle intermediates and sulfate, and influences adiposity, insulin

academic.oup.com

Kelly Nguyen@kellythd-nguyen.bsky.social · last mo.

Honored to be elected to EMBO,together with Manu, Julian and ex-benchmate @wojtekgalej.bsky.social. I’m grateful to all past and present Iab members for their amazing work and support from colleagues, mentors and family over the years.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · last mo.

Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social

Portrait photographs of Julian Sale, Emmanuel Derivery and Kelly Nguyen
Levental Lab@leventallab.bsky.social · 2mo ago

Here's an excellent guide to comment on the OMB's (and potentially catastrophic) rule changes: elizabethginexi.substack.com/p/what-we-ne... By the way, this is not limited to US citizens, anyone can explain how valuable and important US federal funding has been to scientific progress worldwide.

What We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB-2026-0034)

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice

elizabethginexi.substack.com

Levental Lab@leventallab.bsky.social · 2mo ago

The new OMB rules will be a disaster for American science. Please take a few moments to read up and post a comments. Click the link below, it’s easy, fast, and the most important thing you can do to support our community.

Science Magazine@science.org · 3mo ago

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr

After USDA request, Indiana plant biologist locked out of lab by school

Move comes after Roger Innes complained about the government’s prosecution of Chinese postdocs

scim.ag

Ele Willoughby@minouette.bsky.social · 3mo ago

Time for a new edition of Canadian biochemist and medical researcher extraordinaire Maud Menten (1878-1960), 🐡🧪👩🏼‍🔬 #histsci coauthor of the Michalis-Menten equation, inventor of the azo-dye coupling which was the first example of enzyme histochemistry for imaging tissues and the first 🧵

Several copies of my Maud Menten portrait drying on a tabletop. Each linocut shows a portrait of biochemist and medical researcher Maud Menten (1879-1960) with the Michalis-Menten equation in blue and a histology image in pinks and purples in the background.
@qiangguo.bsky.social · 4mo ago

The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

rRNA expansion segments mediate ribosome dimerization as a conserved stress response

Abstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud

doi.org

@qiangguo.bsky.social · 5mo ago

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

Furukawa Lab @CSHL@lab-furukawa.bsky.social · 4mo ago

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

Postdoctoral Position in Membrane Protein Biology & Ion Channel Physiology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

John Rubinstein@johnrubinstein.bsky.social · 4mo ago

Sad news on the passing of Prof. Andreas Engel, a pioneer in the field of cryo-EM (shared with the 3DEM community by Henning Stahlberg). Andreas' kindness, warmth, and enthusiasm for science and his colleagues will be missed.

Dear colleagues, With deep sadness I share the news that Andreas Engel passed away last Wednesday, at the age of 82, after a courageous fight against an aggressive caner. Only half a year ago, he was out hiking in the Italian mountains with his wife Barbara, walking 160 km in a single week. Andreas trained as a physicist in Bern, Switzerland, before heading to John Hopkins University in Baltimore for his postdoctoral work. He then led a research group at the Biozentrum in Basel, and in 1985 took on the role of a group leader in research and development at Ilford Ltd. in Fribourg, Switzerland. In 1987, he joined forces with his colleague Ueli Aebi to establish the Maurice E. Müller Institute at the Biozentrum of the University of Basel. Together, Ueli and Andreas served as professors for structural biology there for almost a quarter century, leaving a lasting mark on the field of structural biology as we know it today. Andreas Engel was a true pioneer. He was among the first to apply atomic force microscopy (AFM) with the tip operating under water, and one of the earliest researchers to perform 3D reconstructions using scanning transmission electron microscopy, achieving remarkable high-resolution maps of porin 2D crystals by STEM. He became a leading expert in membrane protein 2D crystallization, and his group played a key role in the determination of the first aquaporin structure, in collaboration with Peter Agre and Yoshinori Fujiyoshi. As he approached retirement from Basel, Andreas founded the Center for Cellular Imaging and NanoAnalytics (C-CINA) of the University of Basel, which in 2009 operated among others one of the very early Titan Krios instruments. From 2008 also held a professorship at Case Western Reserve University, Cleveland, followed by a position at TU Delft in the Netherlands in 2013. In 2020, he was among the founding members of CryoWrite, a company in Basel that he led as CEO until recently. His contributions to science, to the tools of str…Photo of Andreas Engel
Rich Possemato@richpossemato.bsky.social · 5mo ago

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara.bsky.social ! We took a first principles approach to evaluating @ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. www.biorxiv.org/cgi/content/...

Systematic Evaluation Defines the Limits of Ferroptosis in Cancer Therapy

Ferroptosis is a cell death mechanism characterized by the accumulation of iron-catalyzed lipid peroxides in membrane lipid acyl chains and subsequent loss of membrane integrity.1 Despite thorough investigation of its mechanisms in cultured cells, induction of ferroptosis has unresolved clinical utility in cancer therapy. Here, we systematically evaluate ferroptosis induction via multiple mechanisms, in both cell and tumor models, using focused genetic screens, genetic loss-of-function systems, and pharmacological perturbations. Through this analysis we identify cancer cell line subsets with distinct responses to canonical ferroptosis inducers and suppressors and define the underpinnings of each. Inhibition of central in vitro ferroptosis suppressors GPX4, GCLC, or SLC7A11 across these multiple models fails to impact established tumor growth. In contrast, deficiency in the cytosolic thioredoxin reductase and pharmacologic GCLC inhibition potently induces tumor regression and triggers a form of non-ferroptotic cell death regulated by cystine availability and translation. These analyses further reveal that the principal essential function of environmental cystine in cultured cells is to support selenoprotein function, identified through investigating our finding that beta-mercaptoethanol supports exponential growth in cystine-free conditions. Thus, while ferroptosis activation may be efficacious alone or in combination with other therapies in specific tumor contexts, cell culture systems greatly overestimate the potential anti-cancer effects of ferroptosis induction via the GPX4 axis. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, R01CA286141, R01GM132491, P30CA016087

biorxiv.org

Rita Strack@ritastrack.bsky.social · 6mo ago

We often get questions about the ins-and-outs of Presubmission Enquiries when engaging with scientists. Are they important? Will they help my paper get sent for review? Can they benefit me? If you're curious as well, please check out our editorial in the Feb issue!

Nature Biomedical Engineering@natbiomedeng.nature.com · 6mo ago

Excited to share the February issue! In addition to great research content, we also have an editorial that clarifies how we think about the Presubmission Enquiry at nBME. www.nature.com/natbiomedeng...

David B. Sauer@davidbsauer.bsky.social · 6mo ago

Our study of the CAT1 amino acid transporter and viral receptor is now online in @natcomms.nature.com! Spearheaded by the incredibly talented @mingda-ye.bsky.social with colleagues from @cmd.ox.ac.uk, Strubi, CAMS Oxford Institute, @ndm.ox.ac.uk, and supported by the IM2PACT consortium.

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus - Nature Communications

Cationic amino acids are essential to protein synthesis and cellular signaling. Here, authors determine the structure of the cationic amino acid transporter 1 and determined how it is co-opted as a re...

nature.com

Sjors Scheres@sjorsscheres.bsky.social · 6mo ago

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council

Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

mrc.tal.net