The submission deadline for the ASV Video Abstract Competition is just two weeks away! Submit by July 13! Details at asv.org/comms-competition
Rafael Kroon Campos
@rafaelkcampos.bsky.social
Assistant Professor at Cornell Arbovirus-host interactions
New Research Neutralising antibody responses to MPXV clades Ia, Ib, and IIb after infection or vaccination: a multicountry observational study www.thelancet.com/journals/lan...
Neutralising antibody responses to MPXV clades Ia, Ib, and IIb after infection or vaccination: a multicountry observational study
Humoral immunity elicited by historical or contemporary smallpox vaccination was associated with little neutralising activity across MPXV clades. Of note, previous MPXV clade IIb infection induced cro...
thelancet.com
Interested in arboviruses? Check out our lab's review on alphavirus nsP3! Combining functions like a Swiss Army knife, this viral protein serves as a critical hub for host interactions, being essential for virus replication and driving virus versatility in subverting mosquito and vertebrate cells.
Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay | Journal of Virology
Alphaviruses are enveloped, positive-sense RNA viruses in the Togaviridae family and Alphavirus genus (1, 2). They are transmitted mainly by mosquitoes, which become infected while feeding on a viremic vertebrate host and later transmit the virus during subsequent blood meals (3). For a successful transmission cycle, the virus must replicate in both the mosquito and the vertebrate host. Alphaviruses infect a broad range of vertebrates, including humans, other mammals, birds, fish, and reptiles (4, 5). Their emergence, defined as the first appearance or spread into new regions, and reemergence, a resurgence after a period of decline (6), pose an increasing threat to public and animal health, as well as a substantial economic burden (7, 8). Alphaviruses are classified by the type of disease caused. Encephalitic alphaviruses include Venezuelan, western, and eastern equine encephalitis viruses (VEEV, WEEV, and EEEV). Arthritogenic alphaviruses include Chikungunya virus (CHIKV), o'nyong-nyong virus (ONNV), and Ross River virus (RRV) (1), among others.
journals.asm.org
Why surveillance is important? 4 years ago we predicted a CHIKV outbreak by detecting its silent circulation (lnkd.in/gx7-4ZeQ). Today, the team @mauriciolnogueira.bsky.social provided a genomic and clinical time map of the massive CHIKV outbreak of 2024 in the area. #FAMERP #SBV #ASTMH #UTMB #ACAV
Delighted to see Marielena Saivish's manuscript on the "Standardization of Quantitative Plaque-Based Viral Assays for Orthoflavivirus Cacipacoré" published. A collaborative effort with colleagues on our drive to characterize Brazilian neglected orthoflaviviruses. #UTMBHealth #FAMERP #FAPESP #SBV
We Look forward welcoming you on October 14th for Prof. Kim's webinar "Development of Vaccines Against Alphaviruses and Flaviviruses". Register: www.zoomgov.com/webinar/regi... @astmh.bsky.social @utmbhealth.bsky.social @sbvirologia.bsky.social @mauriciolnogueira.bsky.social @rossilab.bsky.social
New paper out by @mosquitohunting.bsky.social! www.frontiersin.org/journals/mal... This paper explores how variation in mosquito diversity, feeding behavior, vector competence, seasonality, and vector-pathogen interactions shape the transmission, persistence, and evolution of human malaria!
Frontiers | Mosquito vector diversity and malaria transmission
Malaria is the most important parasitic disease in the world, killing over half a million people a year. Globally, we have made gains toward eliminating this...
frontiersin.org
🚨Job alert 🚨 I am looking for an enthusiastic & talented postdoctoral researcher to join our research team in Hamilton, MT, USA. If you are interested in 🦠 emerging respiratory viruses (BSL2-4), 🔬mucosal immunology, and 🐁 in vivo studies, Check out: www.training.nih.gov/jobs/pdpmire...
training.nih.gov
Our study exploring the evolutionary mechanism of alphavirus opal codon retention is now online! www.science.org/doi/10.1126/...
A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses
Alphaviruses optimize viral polymerase production and polyprotein processing at distinct temperatures via a premature stop codon.
science.org
Cheers to our 3y reappointment on tenure track - so grateful to be on this journey at #Cornell alongside Assistant Profs Colleen Lau and Andrew Flyak 🤩
View from my office. What the heck April in Ithaca?! Never imagined I’d be missing spring weather in England…
Our study on the molecular basis of shifts in receptor recognition by western equine encephalitis virus (WEEV) in the past century, led by Xiaoyi Fan and @wanyuviridae.bsky.social , is online! 👏🎉 www.cell.com/cell/fulltex...
Molecular basis for shifted receptor recognition by an encephalitic arbovirus
Cryo-EM structures and mutational analyses reveal western equine encephalitis virus E2-E1 glycoprotein polymorphisms that determine shifted receptor usage and allow for sequence-based prediction of st...
cell.com
Congratulations to @colinparrish.bsky.social, on his well-deserved election to the American Academy of Microbiology! www.cornellsun.com/article/2025...
Prof. Colin Parrish To Be One of 65 New Members of the Microbiology Academy Class of 2025
The Cornell Daily Sun - Independent Since 1880.
cornellsun.com
RNA: I made and ruled this world for eons before your precious proteins even conceived of a peptide bond
Nature Portfolio@natureportfolio.nature.com · last yr.AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
Boom. Accepted for publication in Nature Communications. This paper has been a journey, but it is done. Here, we explore the use of constant temperature experiments to predict the thermal suitability for malaria transmission in a diurnally fluctuating environment. www.biorxiv.org/content/10.1...
Mean daily temperatures can predict the thermal limits of malaria transmission better than rate summation
Temperature shapes the distribution, seasonality, and magnitude of mosquito-borne disease outbreaks. Mechanistic models predicting transmission often use mosquito and pathogen thermal responses from c...
biorxiv.org
The maternal antibody paradox: how are these antibodies both good and bad? Excited to share our new insights for rotavirus vaccines www.biorxiv.org/content/10.1...
Mechanisms of maternal antibody interference to rotavirus vaccination
Maternal antibodies (MatAbs) are transferred transplacentally during pregnancy and through breast milk after birth to provide protection whilst the neonatal immune response is immature. However, MatAb...
biorxiv.org
Glad to have played a small part in this big story! Studying the differences between CD28 in humans and mice reveal reasons for the disastrous 2006 trial www.biorxiv.org/content/10.1...
biorxiv.org
We detected yellow fever virus in Haemagogus mosquitoes collected in 2022 in an Amazon rainforest bordering Manaus, Brazil. The viral genome sequence occupied a basal position within the South American I genotype 1E lineage.
wwwnc.cdc.gov
#Australia🇦🇺: #JapaneseEncephalitis #virus detected in #Brisbane for the first time, triggering health warnings 🦟 www.abc.net.au/news/2025-03...
Japanese encephalitis virus detected in Brisbane for the first time
Queenslanders are being warned against getting bitten by mosquitoes after the Japanese encephalitis virus was found in Brisbane.
abc.net.au
A new study from Femi (Oluwafemi) Adu and our collaborators Susan Hafenstein and Hyunwook Lee, showing the structures of the two main antibody forms in dog found in the polyclonal response to the canine parvovirus capsid after modified-live virus vaccination. www.pnas.org/doi/10.1073/...
@cindyleifer.bsky.social giving an impassioned speech about the attack on science, research, and truth, and calling on all of us to stay vigilant and not to lose hope. Your medicines come from RESEARCH! #scienceisforall #callyourrepresentative
Vaccines work! As measles cases have recently been reported in Alaska, Georgia, New York, Rhode Island and Texas, it's important to remember that prior to the introduction of the measles vaccine in 1963, measles killed 400-500 people and resulted in ~48,000 hospitalizations per year.
Come be our colleague at the Department of Microbiology and Immunology at Cornell! It is a highly supportive environment with exciting science. I am extremely inspired by the extraordinary people here. We are located in beautiful Ithaca, NY.
Sarah Caddy@drsarahcaddy.bsky.social · last yr.We are looking for new colleagues! academicjobsonline.org/ajo/jobs/29722 I can’t recommend the Microbiology and Immunology Department at Cornell Ithaca highly enough.
Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series - The Lancet Infectious Diseases www.thelancet.com/journals/lan....
Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series
We detected OROV IgM in six of 68 newborns with microcephaly of unknown cause. One infant who died had OROV RNA and antigen in several tissues, including the brain. The possibility of OROV vertical tr...
thelancet.com
We look forward seeing you tomorrow at 11 CT for Dr. Lytras' @spyroslytras.bsky.social webinar on "Evolutionary interactions between zoonotic coronaviruses and their hosts". Register at: www.zoomgov.com/webinar/regi.... @createneo.bsky.social @robertwcross1.bsky.social @utmbhealth.bsky.social
Much needed, solid, objective, well done work to realistically assess possible mosquito vectors of the emergent Oropouche virus.
The Global Vector Hub@globalvectorhub.bsky.social · 2y ago🦟 "Lack of Competence of US #Mosquito Species for Circulating #Oropouche #Virus" by Anne F Payne et al. in #EID Journal wwwnc.cdc.gov/eid/article/...
One positive thing that happend this otherwise challenging week is that this paper is FINALLY out. Why are Culex tarsalis so good at spreading West Nile virus? We learned a lot by doing this study. A testament to the tenacity and creativity of Dr. Emily Fitzmeyer. journals.plos.org/plospathogen...
A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection
Author summary West Nile virus is the leading cause of mosquito-borne disease in N. America. Cx. tarsalis is a highly competent vector of WNV that plays a central role in the transmission and maintena...
journals.plos.org
Why are #ZIKV outbreaks rare in Africa, where it was first discovered? New research reveals #mosquito genetics play a more significant role than climate in determining ZIKV transmission patterns. Future projections suggest rising outbreak risks in urban Africa. www.sciencedirect.com/science/arti...
The role of vector population variation and climate in Zika virus transmission patterns in Africa: a modelling study
Zika virus (ZIKV) outbreaks have raised major global health concerns recently, yet reported outbreaks are rare in Africa, where ZIKV was first discove…
sciencedirect.com