How did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...

Intriguing and positive! www.theguardian.com/business/202...

Britain’s markets attracting generation of highly educated entrepreneurs

Nearly a quarter of market traders now hold master’s degree, PhD or medical doctorate, research shows

theguardian.com

Also very cool!

Matthew Taliaferro@jmtali.bsky.social · 2mo ago

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Wow!

Alexey Amunts@amunts.bsky.social · last mo.

RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...

Cool work!

Faraz Mardakheh@mardakheh.bsky.social · last mo.

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

The evolution of structural variation across 500 million years of vertebrate evolution https://www.biorxiv.org/content/10.64898/2026.06.26.733778v1

Terrific resource, now on @biorxivpreprint.bsky.social: The Vertebrate Genomes Project Phase I: A global reference genome resource 🧪🧬 www.biorxiv.org/content/10.6...

The Vertebrate Genomes Project Phase I: A global reference genome resource

The Vertebrate Genomes Project (VGP) aims to produce complete and near-error-free reference genomes for all ∼70,000 extant vertebrate species. Organized in four phases, it progressively targets all ve...

biorxiv.org

Possibly what all British cats are currently thinking about.

Had to! "So we sailed on to the sun 'Til we found a sea of green" 🎵🎼🎶

Great. Goes well with this paper on how to write bad papers: doi.org/10.1111/j.00...

Agree 100%

Itai Yanai@itaiyanai.bsky.social · last mo.

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

Super interesting!

Hiten Madhani@hitenmadhani.bsky.social · 2mo ago

A strong hint from human genetics that changes in DNA methylation may be causal for normal aging. This is the direction that aging (and cancer) research needs to go! www.nature.com/articles/s41...

Interspecies variation of 45S ribosomal DNA in vertebrates https://www.biorxiv.org/content/10.64898/2026.06.09.731232v1

Our next guest speaker webinar is happening on Friday, 12th June, 15:30-16:30pm BST. Madzia Crossley, will be giving a talk on ''Distinct mechanisms generate immunogenic cytoplasmic RNA-DNA hybrids as signals of transcriptional dysregulation'' Follow this link to join: www.qmul.ac.uk/epigenetics/...

Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/... 🦠

Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics

Characterization of large molecular machines, such as the ribosome, under a breadth of biological states to elucidate regulatory details remains challenging. Herein, a workflow combining complex-up na...

pubs.acs.org

Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/

Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian - Nature Ecology & Evolution

Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...

nature.com

Very nice!

Sendoel Lab@sendoellab.bsky.social · 3mo ago

Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @cp-molcell.bsky.social. Fantastic work by @claradure.bsky.social and all co-authors involved. www.cell.com/molecular-ce...

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Truly embarrassing….

Sholto David@sholtodavid.bsky.social · 3mo ago

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

The human genome's most variable and clinically important regions (centromeres, telomeres, and acrocentric short arms) have been hardest to study at scale. Thrilled to share KaryoScope, our new preprint that brings them within reach. 🧵 www.biorxiv.org/content/10.6...

Based on 25RM3 outcomes, #BBSRC success rate for standard research grants is now down to 13%….

This will be a great resource! www.nature.com/articles/s41...

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

nature.com

We are very happy to kick off the #DNAmethylation course with @alexdemendoza.bsky.social Hollie Marshall James Ord and a great group of attendees from all over the globe! www.physalia-courses.org/courses-work...

And a very nice article by @cofford.bsky.social in Science covering our work: www.science.org/content/arti...

More acrocentric investigations, this one led by @arhie.bsky.social 🕵🏻‍♀️ “Biobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomes” 🧵[1/8] 📄 www.biorxiv.org/content/10.6...

Super happy to share the published version of our study: “Germline sequence variation within the ribosomal DNA is associated with human complex traits” in Cell Genomics www.cell.com/cell-genomic...!

Very interesting!

Benjamin Towbin@betowbin.bsky.social · 4mo ago

New paper alert: Our latest shows how maternal diet impacts ribosome levels and early growth intergenerationally in #Celegans Led by Sigma Pradhan and in collab with @nstroustrup.bsky.social journals.plos.org/plosbiology/... @plosbiology.org @izb-unibern.bsky.social @unibe.ch

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances! He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding. See more details in EMBL post below!

EMBL@embl.org · 4mo ago

(1/2) EMBL researchers led by @olivierduss.bsky.social have developed a microscopy technique that enables them to observe individual RNA molecules being produced and folding into different shapes. Learn more: www.science.org/doi/10.1126/...

Ominous seating arrangements.