Tessera
Folgen

@raphmercier.bsky.social

#Meiosis4ever. #ChromosomeBiology. Max Planck for Plant Breeding Research.

69 Posts1492 Follower288 Folgt
@raphmercier.bsky.social · 9mo ago

www.nature.com/articles/s42... Latest from the lab. The conclusion is in the title! Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)

The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms - Communications Biology

Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organization across k...

nature.com

Chloe Girard, PhD@chloegirard.bsky.social · 10mo ago

This is the work of a tremendous PhD student, Benoit Madec, who did everything in this study (genetics, molecular biology, all the bioinformatics analyses) He defended his PhD on Monday and is now Dr Madec! I am very proud of him and all the work he has accomplished!

Benoît during his PhD defense on Monday!
Chloe Girard, PhD@chloegirard.bsky.social · 10mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Chloe Girard, PhD@chloegirard.bsky.social · 10mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Maddy Seale@maddyseale.bsky.social · 11mo ago

Out First Release in @science.org this week: A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability www.science.org/doi/10.1126/... #PlantScience

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

science.org

@wcrismani.bsky.social · 11mo ago

I feel incredibly privileged to share this study on Fanconi anaemia, based on a small but important cohort. This work describes the genetics and clinical outcomes of patients in Australia and New Zealand with a diagnosis of FA. www.sciencedirect.com/science/arti...

Clinical and genetic spectrum of Fanconi anemia in Australia and New Zealand

Fanconi anemia (FA) is a rare genetic condition that predisposes to progressive bone marrow failure, a specific spectrum of malignancies, including he…

sciencedirect.com

Schnittger Lab@schnittger-lab.bsky.social · 12mo ago

Six more years—plus a lot of blood, sweat, and tears—later, we are thrilled to finally share it: a cytological framework of female meiosis in Arabidopsis! www.biorxiv.org/content/10.1...

A cytological framework of female meiosis in Arabidopsis

Female and male meiosis often differ in many aspects, such as their duration and the frequency as well as the positioning of crossovers. However, studying female meiosis is often very challenging and ...

biorxiv.org

@raphmercier.bsky.social · 12mo ago

Preprint Alert! 🚨🧬 Not one, but two preprints! Meiotic orientation of kinetochore at meiosis is inforced by...[see below] www.biorxiv.org/content/10.1... and Unlocking meiotic crossovers next to plant centromere www.biorxiv.org/content/10.1... #meiosis4ever #everythingisconnected a thread👇

Monopolar orientation of kinetochores at meiosis is enforced by COHESINS and their regulators, CENP-C, and the deSUMOylase SPF2

The first division of meiosis is unique in its capacity to halve the ploidy of the future gametes. To this end, one key innovation compared to mitosis is the monopolar orientation of the pairs of sist...

biorxiv.org

Molecular Biology and Evolution@molbioevol.bsky.social · 12mo ago

@alisondawnscott.bsky.social et al. use genome data from >400 Arabidopsis lyrata sampled across Eurasia to show it as the most polyploid-rich species complex in Arabidopsis, with multiple origins of autotetraploidy. 🔗 doi.org/10.1093/molbev/msaf153 #evobio #molbio #PlantSky

Multiple Autopolyploid Arabidopsis lyrata Populations Stabilized by Long-Range Adaptive Introgression Across Eurasia

Abstract. Abundance of established polyploid lineages varies across lineages, evolutionary time, and geography, suggesting both genetics and environment pl

doi.org