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Chloe Girard, PhD

@chloegirard.bsky.social

Personally done with meiosis I. Professionally in love with it. Permanent researcher at I2BC 🇫🇷 Arabidopsis 🌱 Sordaria 🍄 Genetics/Genomics 🧬 Fixed and live imaging 🔬. #meiosis4ever her/she

422 Posts1430 Follower1113 Folgt
RIKEN Center for Biosystems Dynamics Research (BDR)@riken-bdr.bsky.social · 9mo ago

Team led by Tomoya Kitajima designed protein-based artificial #kinetochores to act as decoys to reduce bipolar microtubule pulling forces on chromosomes in aged mouse #oocytes, preventing premature #ChromosomeSegregation during meiosis I & II. In @natcellbio.nature.com 👇 doi.org/10.1038/s415...

Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes - Nature Cell Biology

Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...

doi.org

Emanuel Maiberg@emanuelmaiberg.bsky.social · 10mo ago

wikipedia's data shows that AI is siphoning traffic away from the site, which is a danger to its sustainability. ironically Wikipedia is more important than ever to users who want reliable information instead of slop, and to AI companies that need it for training data www.404media.co/wikipedia-sa...

Wikipedia Says AI Is Causing a Dangerous Decline in Human Visitors

“With fewer visits to Wikipedia, fewer volunteers may grow and enrich the content, and fewer individual donors may support this work.”

404media.co

Chloe Girard, PhD@chloegirard.bsky.social · 10mo ago

1st desk rejection ! I am very proud of this paper and will persist nevertheless, Wish me luck (and share the paper widely ! Yes, I am doing shameless self-promotion) ! 💪

Chloe Girard, PhD@chloegirard.bsky.social · 11mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Marie Monniaux@mariemonniaux.bsky.social · 11mo ago

Wow this is quite amazing - I know almost nothing on recombination, but always assumed that the more similar the sequences were, the more likely they would recombine, turns out it's the opposite!

Chloe Girard, PhD@chloegirard.bsky.social · 11mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Chloe Girard, PhD@chloegirard.bsky.social · 11mo ago

This is the work of a tremendous PhD student, Benoit Madec, who did everything in this study (genetics, molecular biology, all the bioinformatics analyses) He defended his PhD on Monday and is now Dr Madec! I am very proud of him and all the work he has accomplished!

Benoît during his PhD defense on Monday!
Chloe Girard, PhD@chloegirard.bsky.social · 11mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Chloe Girard, PhD@chloegirard.bsky.social · 11mo ago

🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
Harmit Singh Malik@harmitmalik.bsky.social · last yr.

One thing to emphasize strongly is that funding to science is like oxygen to the brain. Temporarily restricting oxygen flow for ten minutes (while you figure your shit out) is going to have the same outcome as shutting oxygen off permanently. We are close to the ten minute mark.

Harmit Singh Malik@harmitmalik.bsky.social · last yr.

The current administration has more successfully destroyed US science and the scientific enterprise than the hypothetical nuclear weapons program in Iran.

Tania Louis@tanialouis.fr · last yr.

Je reprends la métaphore de Robin Jamet : mobilisons-nous pour le Palais de la découverte et faisons-en le panda de la CSTI, l'espèce emblématique qui attire l'attention sur l'état d'un écosystème et amène à le préserver. 🐼

La Science, CQFD@sciencecqfd.bsky.social · last yr.

#Podcast du jour > Né sous l’impulsion de Jean Perrin en 1937, le Palais de la découverte est fermé depuis 2020 pour rénovation, le doute plane désormais sur sa réouverture en 2026, et sur l'avenir de la culture scientifique en général tinyurl.com/27kd37vu à (ré)écouter sur @franceculture.fr !

Yann Duroc@durocyann.bsky.social · last yr.

Rappel parce qu’apparemment c’est pas intégré par tout le monde : Les variétés issue de mutagenèse aléatoire sont bien des OGM (décision de la CJUE en 2018) mais elles sont exemptées de régulation. Ainsi elles sont exemptées de mesures de traçabilité et d’évaluation des risques !

Chloe Girard, PhD@chloegirard.bsky.social · last yr.

Look at that red nucleus stretching like CRAZY ! Who knew nuclei could do that ! DNA stretching, sure, but what about the nuclear membrane ?! (scale bar 10µm !) The longest measured nucleus reached 71µm !!

Pierre Grognet@pierregrognet.bsky.social · last yr.

I am very proud to be part of this story! Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina. www.biorxiv.org/content/10.1...

Paul Graf@paulginva.bsky.social · last yr.

Man comes to the US from Lebanon. Starts out delivering pizzas, becomes a Nobel winning neuroscientist. Trump freezes his funding, he gets an email from China offering to move his lab “any city, any university I want" with guaranteed funding for 20 years. What are we doing?

Ardem Patapoutian's story is not just the American dream, it is the dream of American science. He arrived in Los Angeles in 1986 at age 18 after fleeing war-torn Lebanon. He spent a year writing for an Armenian newspaper and delivering Domino's at night to become eligible for the University of California, where he earned his undergraduate degree and a postdoctoral fellowship in neuroscience. He started a lab at Scripps Research in San Diego with a grant from the National Institutes of Health, discovered the way humans sense touch, and in 2021 won the Nobel Prize. But with the Trump administration slashing spending on science, Dr. Patapoutian's federal grant to develop new approaches to treating pain has been frozen. In late February, he posted on Bluesky that such cuts would damage biomedical research and prompt an exodus of talent from the United States. Within hours, he had an email from China, offering to move his lab to "any city, any university I want," he said, with a guarantee of funding for the next 20 years.
Chloe Girard, PhD@chloegirard.bsky.social · last yr.

What a joy it was! Thank you to @namekawasatoshi.bsky.social and @cohenlab.bsky.social for their HUGE help organizing this meeting !! The French crew will organize next year's meeting as well, but will hand over the reins to another #Meiosis4ever community for 2027 !

MAYosis@mayosis.bsky.social · last yr.

It's a wrap for #MAYosis25 ! Thank you to all speakers for sharing their latest data, it was a great meeting! Thanks to all the attendees for all the questions, this is a truly vibrant community! See you next year! --> updated Meiosis4ever starter kits go.bsky.app/P3BJYze go.bsky.app/Tdxbm9b

Carl T. Bergstrom@carlbergstrom.com · last yr.

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years. It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

Plot of life expectancy after Type 1 diabetes diagnosis, 1850-2025. After the discovery of insulin in 1921, life expectancies go gradually from zero to seventy years.