Schnittger Lab

@schnittger-lab.bsky.social

An international team of cell biologists, molecular biologists, and biochemists investigating the cell cycle, meiosis and DNA damage in plants.

Finally, here it is: after 12 years, and driven by the incredible hard work and innovation of two Ph.D. students, Bingyan Hu and Maria Prusicki, with biomathematical support from Katarina Stahlmann (UKE) — "A cytological framework of female meiosis in Arabidopsis". academic.oup.com/plcell/artic...

A cytological framework of female meiosis in Arabidopsis

Live-cell imaging reveals characteristic cytological stages of female meiosis in Arabidopsis and allows an assessment of their durations.

academic.oup.com

How do plants control the genes needed for successful sexual reproduction? Our new work uncovers the DREAM complex as a crucial regulator of meiotic recombination in Arabidopsis. Without DREAM, plants are sterile—key recombination genes like MER3 are switched off...

The identification of the very conserved CTF18, SGO2 and SPF2 as suppressors of centromere-proximal crossovers highlights the importance of cohesin turnover in this process and opens up new possibilities for plant breeding. Much more in the paper : www.biorxiv.org/content/10.1...

Unlocking meiotic crossovers near plant centromeres

Crossovers (COs) ensure proper chromosome segregation during meiosis and generate genetic diversity. COs are non-uniformly distributed along chromosomes and almost universally suppressed in centromere...

biorxiv.org

After 12 years… In 2014, a wild idea was born: to follow female meiosis in Arabidopsis in real time. After many trials (including experiments with quirky mutants where female organs developed inside out, and a few other unconventional ideas), we switched gears to image the male side.

Second: Some new findings about chromosome segregation in Arabidopsis! We’ve characterized TITAN9 (TTN9), a distant Csm1-like protein in Arabidopsis. Proteomics revealed TTN9 associates with multiple kinetochore components, including DSN1.

Functional characterization of the Csm1-like protein TITAN 9 in Arabidopsis thaliana

Plant genetics; Plant bioinformatics; Plant Biology; Plant physiology; Plant systematics; Plant evolution; Plant development

cell.com

First up: understanding how plants defend themselves against heat stress. Our recent Science Advances paper shows that the meiotic cyclin TAM localizes to stress granules—special biomolecular condensates—during meiosis.

The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat

The concentration of a meiotic regulator into membrane-less compartments assures genomic stability during reproduction.

science.org

The Schnittger lab is located in Hamburg/Germany and represents an international team of cell biologists, molecular biologists, and biochemists investigating the cell cycle, meiosis and DNA damage in plants. Here, we will post the latest information from and about the lab.

The Schnittger lab is happy to join BlueSky. We just re-located from the former twitter platform that became unbearable for us to support due to the homophobic, unsocial and democracy-threatening behavior of its new owner.