Phenomenal narrative review of SBP prophylaxis by @vinayjaha.bsky.social in @liverfellownetwork.bsky.social. www.aasld.org/liver-fellow... Discusses the literature, new and old, and the emerging antibiotic resistance. Certainly something to share with my trainees! @cwruim.bsky.social

Outstanding review of AAT deficiency. Bookmarked this one as a reminder of: ✅️Genetics & Pathophysiology ✅️AAT phenotypes ✅️SZ phenotype and ⬆️ cancer risk ✅️Controversies with plasma-purified AAT #LiverSky #MedSky

This trend is *very* concerning given that alcohol damages the liver of females at 2x the rate of males. We are seeing so many young females (20s and 30s) who get very sick and often die from🍸🍷🍻-associated liver disease! We need to work on strategies to 📉 alcohol use in this population! #liversky

JAMA@jama.com · last yr.

Past-month binge drinking among young adult females in 2021-2023 was higher than among males, reversing 2017-2019 patterns, whereas males in other age groups continued to binge and heavy drink at higher rates. https://ja.ma/42pf2V6 #MedSky

A practical review of new AGA guidance on PVT management by @drjessicadavis.bsky.social #liversky 📍don’t delay AC 📍can hold AC for EGD for 48 hours 📍AC does NOT increase risk of bleeding from varices while you wait for EGD

Congrats to Thailand for nearly eliminating vertical transmission of hepatitis B The vaccine works doi.org/10.12932/ap-...

The famous "Table 7" from the Gupta et al. paper on surveillance of colon polyps. A paper I refer to regularly in my practice and when teaching fellows. A must-read for all GI trainees. Note the second surveillance intervals. #GISKY #MedSky @cwruim.bsky.social pubmed.ncbi.nlm.nih.gov/32044092/

Great consensus statement about de novo malignancy screening after liver transplant. It also reviews management of immunosuppression with de novo malignancies, including mTOR inhibitors. #Liversky journals.lww.com/transplantjo...

De Novo Malignancy After Liver Transplantation: Risk... : Transplantation

- to 3-fold higher in transplant recipients than in age- and sex-matched healthy controls. Long-term immunosuppressive therapy, which is the key in maintaining host tolerance and achieving good long-t...

journals.lww.com

It was a privilege to share and moderate a great case presentation by Dr. Satoi at #LiverRounds with @ohioliver.bsky.social There was a great turnout of hepatologists, fellows, and residents.

This is an interesting letter to the editor that highlights the pitfalls of poorly validated ICD-10 codes and confirms my growing concerns with the increasingly popular but alarmingly weak TriNetX database and platform @zachsmithgi.bsky.social #gisky #liversky

A well-written review of new and established therapies for PBC and PSC that covers: ✅️Drug mechanisms ✅️Clinical trial results/efficacy ✅️Side effects #Liversky #GiSky pubmed.ncbi.nlm.nih.gov/39480026/#:~....

Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Therapy Landscape - PubMed

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare, and chronic cholestatic diseases that can progress to liver failure. The goals of treatment are to halt the progres...

pubmed.ncbi.nlm.nih.gov

There are three reasons why platelets are low in advanced liver disease Low TPO Portal hypertension (sequestration) Immune-related destruction #liversky

NEJM.org@nejm.org · last yr.

Case Record of the MGH: A 65-year-old woman was evaluated for back pain and pancytopenia. A peripheral-blood smear was notable for nucleated red cells, large platelets, and immature granulocytes. A diagnosis was made. Full case details: nej.md/4bfXXBf #MedSky #Oncology

Our first edition of Tavill Liver rounds is coming up March 5, 2025 at Embassy suites in Independence OH Look for educational, passionate discussions and great educational content. Come support our trainees from @metrohealthcle.bsky.social @clevelandclinic.bsky.social and university hospitals!

Challenge for #liversky : Monitoring regression/progression on resmetirom & deciding on alternative treatments ▶️ AASLD provided guidance ▶️ We commented on the role of LSM: doi.org/10.1097/HEP.... ‼️ Random variation in LSM >25% ‼️ Consider overall medical benefit (e.g., GLP-1)

The correct term is conjunctival icterus. The expression "scleral icterus" was previously and incorrectly perpetuated. See this scathing remark in @jama.com by an ophthalmologist. jamanetwork.com/journals/jam... #Liversky #GiSky #Medsky @cwruim.bsky.social

'Conjunctival Icterus,' Not 'Scleral Icterus'

To the Editor.—  The expression "scleral icterus" generally used by physicians is grossly incorrect. For decades, physical diagnosis primers have cued medical students to look for "scleral icterus...

jamanetwork.com

Great review of hemangiomas, FNH, & more by @renumathyd.bsky.social! I encourage all learners to read the classic imaging features. ✅️Review the imaging yourself ✅️Follow up if >5cm ✅️Biopsy for atypical appearance journals.lww.com/hepcomm/fullte… @jhepatology.bsky.social #Liversky #GITwitter

Great case-based review of acute pancreatitis in @AmJGastro. Remember: ✅️Classic pain + Lipase >3x ULN = Dx ✅️CT isn't always needed ✅️Early, goal-directed fluids! ⬇️BUN ⬇️HGB ⬆️UOP ✅️Early nutrition pubmed.ncbi.nlm.nih.gov/38857482/ #GISky #MedSky @cwruim.bsky.social

Must-read concise and case-based review of #AIH and therapies published in AJG ✅️Identify the AIH phenotype ✅️Pred+MMF could be >Pred+AZA ✅️Beware! MMF teratogenicity ✅️Tacro troughs: 6-8, then 3-5 #LiverSky #GiSky #MedSky @cwruim.bsky.social journals.lww.com/ajg/citation...

Autoimmune Hepatitis and the Pathways and Targets for... : Official journal of the American College of Gastroenterology | ACG

An abstract is unavailable.

journals.lww.com

Prednisolone for alcohol associated hepatitis? Literature suggests waiting ~1 week before starting. Here's reasons I avoid it: ⛔️Infection ⛔️GI Bleeding ⛔️Renal failure ⛔️Critical illness ⛔️Noncompliance journals.lww.com/hep/abstract/9… #LiverSky #GiSky #MedSky

A citywide collaboration with @clevelandclinic.bsky.social, @UniversityHospitals, and @metrohealthcle.bsky.social to promote knowledge and liver health. Check out the link for the 2025 program calendar! mailchi.mp/170574b9a487... #Liversky #GiSky #Medsky @livermd.bsky.social

Beautiful sunset after a productive afternoon in transplant clinic. @UHhospitals @SeidmanCancerCenter

journals.lww.com/hepcomm/full... Great review covering risk factors for #HCC: ✅️ HBV is the #1 cause of HCC ✅️ Aflatoxin and its expanding contamination with #GlobalWarming ✅️ Vinyl chloride is associated with HCC and angiosarcomas ✅️ Others like pollution, arsenic, T2DM #LiverSky #GISky #MedSky

Environmental exposures and the risk of hepatocellular... : Hepatology Communications

itis (HBV and HCV), and exposure to chemical agents like aflatoxin, alcohol, tobacco, and air pollution. This review examines how environmental exposures and evolving liver pathology, exacerbated by l...

journals.lww.com

Elliot Tapper@ebtapper.bsky.social · 2y ago

How the environment impacts the liver And the risk of liver cancer Phenomenal review in Hep Comm: journals.lww.com/hepcomm/full... #liversky #medsky

Hello #LiverSky and #GISky! Happy to join this growing community. I am a junior attending who's new to Cleveland and passionate about hepatology and education.

💡PEth gets another win! Compared to previously used non-invasive tests in differentiating MetALD from MASLD #liversky onlinelibrary.wiley.com/doi/abs/10.1...

Head‐to‐Head Comparison Between Phosphatidylethanol Versus Indirect Alcohol Biomarkers for Diagnosis of MetALD Versus MASLD: A Prospective Study

Using a well-phenotyped prospective cohort with systematic assessment through MRI-PDFF, MRE, and PEth testing, this study demonstrates that PEth is an accurate, quantitative, objective alcohol biomar...

onlinelibrary.wiley.com