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Reid Olsen

@reidolsen.bsky.social

Drug discovery scientist at Recursion, previously Exscientia, molecular pharmacology PhD, Pac NW born and raised, ex-expat back in the USA, dog person, occasional sleeper. Opinions are my own and obviously correct.

696 Posts832 Follower1338 Folgt
Reid Olsen@reidolsen.bsky.social · 2mo ago

Why is deformation microscopy desirable? Amino acid scale distances are relevant because of the physical properties of the individual atoms interacting with others including waters etc. in space. This is like saying "we took kublah Kahn and exploded it on the football field look how long it is!"

biorxiv.org

Peter Škrinjar@peterskrinjar.bsky.social · 3mo ago

Now published in NSMB! Paper: doi.org/10.1038/s415... Full PDF: rdcu.be/fhBtI Overview of additions since the preprint👇 (1/5)

Evaluating generalization in protein–ligand cofolding methods - Nature Structural & Molecular Biology

This work introduces the Runs N’ Poses dataset for benchmarking deep learning methods on the protein–ligand complex prediction task. It shows that current methods rely on memorization, challenging the...

doi.org

Peter Škrinjar@peterskrinjar.bsky.social · last yr.

Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹! www.biorxiv.org/content/10.1... 🧵👇 (1/n)