Riyue Sunny Bao , PhD
@riyuesunnybao.bsky.social
Multiomics • Spatial imaging • I-O • AI. Asso Prof #Medicine. PI @ImmunoTiil . Director #Bioinfo @UPMCHillmanCC. Co-Chair #COWG. Lab: http://tiilab.org
Good morning everyone! Would somebody please #endorse me on cs.CV #ComputerVision and #PatternRecognition of #arXiv? We are submitting an article for the first time! Link below ;) arxiv.org/auth/endorse... Or pls visit arxiv.org/auth/endorse... and enter Code: 9I4F67 Thanks in advance!! 😍
🥳 We’re #hiring! 🎉 🎉 🎉 tiilab.org #Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy. Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
TII Laboratory
tiilab.org
The UK's Medicine & Healthcare products Regulatory Agency (MHRA) became the 1st regulator globally to approve the new oral women's health drug by Bayer (originally through KaNDy Therapeutics acquisition) #biosky
Pearl Freier@pearlf.bsky.social · last yr.Bayer bought a UK-based women's health-focused biotech in Phase 2b clinical trials, KaNDy Therapeutics, for $425M upfront in '20. VCs incl Forbion, OrbiMed, Advent & Fountain. Lynkuet for menopause & perimenopause symptoms received UK reg approval last wk www.gov.uk/government/n... #biosky
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | New England Journal of Medicine nejm.org/doi/abs/10.105…
nejm.org
Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer! First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape. t.co/1YUzihcY2H #nonanimal #alternative #methods #cancer #immunotherapy
A high proportion of CD38 (high) CD16 (low) NK cells in tumor patients can interrupt immune surveillance and favor tumor growth link.springer.com/article/10.1...
New Journal for ImmunoTherapy of Cancer article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma bit.ly/4lcxHLC @riyuesunnybao.bsky.social @pancpathologist.bsky.social @zervanto.bsky.social @jasonlukemd.bsky.social #JITC #cancer #MedSky
🚀First time joining #ENAR2025 and ✨Grateful to share our lab's work leveraging #singlecell #spatial #pathomics #radiomics to understand resistance/response in #cancer #immunotherapy. Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
Looking forward to #ENAR2025!! I will be discussing our lab's new work in using #singlecell omics and #radiomics to understand resistance and response in patients who received #immunotherapy. Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
We have a #research tech job open 🤩 if you are interested in quickly gaining experience in #translational & #clinical space, DM /send me your CV. #master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!! #standupForScience #standupAgainstCancer
a little girl wearing sunglasses and a blue dress is dancing on the floor .
ALT: a little girl wearing sunglasses and a blue dress is dancing on the floor .
media.tenor.com
Where are the #AI #Agents who can clean up/reformat all publication #figures and #deposit big data cuz I would like to buy one Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
a man in a suit sits at a desk with the words " these are busy times " written on the bottom
ALT: a man in a suit sits at a desk with the words " these are busy times " written on the bottom
media.tenor.com
Back to #Nak #Won Garden and loving it!!! The best #authentic #korean food in the Burgh. Plus Friendly environment and super nice owners 😍
Human-relevant neuroscience research is everywhere, but so many many poorly translatable experiments on animals still get funded. Why? One reason: Grant reviewers are mostly animal experimenters themselves. New preprint from @katherineroe.bsky.social & me 🧵 🧪 www.biorxiv.org/content/10.1...
Here is a growing list of #universities and #programs that have to reduce or pause graduate admission as a consequence of indirect cuts, and funding freeze. We are witnessing an entire generational loss of #science.
Carolyn Ibberson@cbibberson.bsky.social · last yr.I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Dr Rose Doerfler from our lab #ImmunoTiil presenting her work in #headNeck #cancer patient derived #organoids #TRCCC2025. Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!! Check Rose poster #62 tonight to learn more!
Dr Alan Hutson, Chair of Biostats and Bioinfo Dept #RoswellPark Cancer center giving keynote #immunoOncology translational network #IOTNmoonshot at #TRCCC2025 annual meeting !!! 🚀Especially important for today’s scientific landscape
#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types! tinyurl.com/5h2v8tak
Has it occur to anybody that a non-profit initiative should be put together to #backup all #US #government funded #data #repositories, such as GEO, SRA, GDC, among many others? It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
At these bleak times when the intent seems to be to cripple NIH-funded research, a reminder that NIH funding sustains the economy and creates jobs “In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity.” www.nih.gov/about-nih/wh...
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
nih.gov
#pathology #AI twitter - recommendations on a reliable predictor of #HPV status directly from #HE images in #HNSCC, that has been validated in large datasets across sites #opensource? We could build our own models but do not wish to reinvent the wheel if great tools already exists. Thank you !!
🚀 Exciting news! The brand-new #Y2025 #SITC #CompIO Webinar Series is here!!! 🎉 Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏 ✨ FREE registration: tinyurl.com/3863jp9t Let's spread the word!🚀
Society for Immunotherapy of Cancer@sitcancer.bsky.social · 2y ago#SITC is pleased to announce the 2025 SITC-NCI Computational Immuno-oncology Webinar Series! This series will focus specifically on advanced methods and clinical utility for biomarker development in #IO. Learn more about these ten free webinars & register: sitcancer.org/CompIO
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
An integrated transcriptomic cell #atlas of #human #neural #organoids: 36 #singlecell #transcriptomic datasets spanning 26 protocols, totalling 1.7+ million cells. www.nature.com/articles/s41... Interactive portal: archmap.bio#/ Great resource for all researchers in this field!!
Convergence of evolving #AI and #ML techniques: #multiomic, #spatial imaging, #pathology, #radiomic technologies enable a deeper understanding of #tumor #biology & #precision #oncology, such as building virtual #digitaltwins to optimize trial design. www.nature.com/articles/s41...
After battling the impossible parking in lawrenceville 🥷 we had a delicious meal at #Tram’s kitchen #split #rice 🤤 and made to #sungazer concert @ #thunderbird cafe & music hall ☀️ 🎷🎸🥁 which we had missed , for the past three times when they came to #Pittsburgh 🥹
#Artificialintelligence-based #biomarkers for treatment decisions in #oncology: #radiology #pathology #omics #EHR #LLM clinical implementation requires validation, prospective trials, medicoeconomic eval while extending #personalized #medicine to a broader population. www.cell.com/trends/cance...
