Almost a year after our Nature paper, @ukbiobank.ac.uk has published a great explainer of our work on parent-of-origin effects. A nice read if you're curious why the same variant can have opposite effects depending on which parent it came from. 🔗 www.ukbiobank.ac.uk/research-sto...

#eshg2026 Early Career awards: Bryce Sebastian Rampal (Montréal, CA) Tanja Frey (Zurich-Schlieren, CH) Anthony Edward Francis McGuigan (Oxford, UK) Irena Josephina Johanna Muffels (Utrecht, NL) Samuel Moix (Lausanne, CH) Lea M Urpa (Helsinki, FI) James Russ-Silsby (Exeter, UK)

#eshg2026 Lodewijk Sandkuijl Award: Best presentation in the field of complex disease and statistical genetics. Théo Schneider (Helsinki, Finland) Accurate maternal and paternal haplotype inference reveals new parent-of-origin effects in the Finnish population Presentation Number: C36.2

Evaluating anonymized genome re-identification using polygenic predictions and its implications for data privacy https://www.biorxiv.org/content/10.64898/2026.06.10.731306v1

Excited to share my first preprint on federated conditional analysis of rare single variant and aggregate association tests across six genetically-inferred ancestry groups in All of Us and UK Biobank doi.org/10.64898/202...

Hi network 👋 ⏰ Don’t miss it! #EMGM2026 in Davos (Switzerland) 🏔️ 📅 14–15 April 2026 📝 Abstract deadline: 1 February 2026 ✈️ Travel grants available 🎤 Amazing lineup of invited speakers 🔗 Details: emgm2026.sciencesconf.org

Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social

I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months! Aardvark: Sifting through differences in a mound of variants GitHub: github.com/PacificBiosc... Some highlights in this thread: 1/N

GitHub - PacificBiosciences/aardvark: A tool for sniffing out the differences in vari-Ants

A tool for sniffing out the differences in vari-Ants - PacificBiosciences/aardvark

github.com

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 10mo ago

Aardvark: Sifting through differences in a mound of variants https://www.biorxiv.org/content/10.1101/2025.10.03.680257v1

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. www.biorxiv.org/content/10.1...

Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇 www.sib.swiss/news/the-imp...

The impact of genetic variants can depend on the parent they come from

Traits such as height, metabolism, and disease risk can be affected differently – and even in opposite directions – depending on whether the genetic variant responsible is inherited from the mothe...

sib.swiss

Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in ‪@nature.com 👍 ‬ www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

nature.com

Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating! Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏

Robin Hofmeister@rjhfmstr.bsky.social · 12mo ago

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.

Robin Hofmeister@rjhfmstr.bsky.social · 12mo ago

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

@snsf.ch @estresearchcouncil.bsky.social @fannydhelia.bsky.social @jaanikakronberg.bsky.social @mvaudel.bsky.social @srubinacci.bsky.social @lilimilani.bsky.social @natureportfolio.nature.com

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale. 🔗 www.nature.com/articles/s41...

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

nature.com

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Thrilled to receive the Early Career Award for my presentation at #ESHG2025! 🧬 Big thanks to all the amazing collaborators on this project — couldn't have done it without you. Grateful to the organizers and inspired by the science shared this week!

Zoltán Kutalik@zkutalik.bsky.social · last yr.

Extremely proud of @rjhfmstr.bsky.social for his @eshg.bsky.social Early Career Award received yesterday in Milan. A truly deserved recognition of his outstanding presentation and ingenious research on parent-of-origin effect inference! #ESHG2025

Particularly interesting talk from @rjhfmstr.bsky.social @ #ESHG25. Impressive work coming out of @unil.bsky.social 🧬🚀

🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (@zkutalik.bsky.social) is coming in force!
 Check out our latest work on human genetics! 
📍Come see our talks & posters, or reach out to meet us!

Very excited to give a virtual talk as part of the @eshg.bsky.social webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...

🚨 New paper 🚨 Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery? 🔍 10,960 people, 9 biobanks, 6 countries 🧬 Minimal genetic impact on GLP1-RA response 📉 Modest effect after surgery www.nature.com/articles/s41...

Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery - Nature Medicine

The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonis...

nature.com

After 6 (healthy) months of hiatus from social media, first post with a brand new conference announcement!! 🔥COMPUTATIONAL BIOLOGY IS EVERYWHERE! Join us in Lausanne for the first international Computational Biology Symposium! 18-19 September 2025 Registrations are OPEN! cbiosymposium.unil.ch

Only two weeks left to apply to the Leena Peltonen School of Human Genomics. Stellar faculty, free accommodation and no registration fee. Unique format: 20 students:20 tutors, presenting their science and learning together. lpshg.com

Here are some cool animations I made a couple years ago for teaching DAG-based causal inference Confounding!

EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org

Just 10 days to go until the EMGM2025 abstract submission deadline! emgm2025.sciencesconf.org?lang=en Registration is also now up and running. Hope to see you all in Brest

🚨 Preprint update! We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals! Discover fresh insights into the genetic architecture of early growth! Updated preprint: www.medrxiv.org/content/10.1...

Robin Hofmeister@rjhfmstr.bsky.social · 2y ago

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health. 👉 Read here: www.medrxiv.org/content/10.1... 👇 Highlights below!

Abstract submissions for the European Mathematical Genetics Meeting are open! emgm2025.sciencesconf.org Deadline February 2nd, looking forward to seeing your proposals. Meeting is in Brest, France, 8-9 April

Just out in @naturehumbehav.bsky.social ! We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings shorturl.at/N4Qc6

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation - Nature Human Behaviour

Biobank data are extensively used. Schoeler and colleagues show that self-report inaccuracy and selective participation are sources of poor reproducibility for biobank-scale research.

shorturl.at

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at www.lpshg.com