📢 Join us for the next #ReproT with Prof. Kevin Esterling! He'll be discussing: 💡 𝗧𝗵𝗲 𝗻𝗲𝗰𝗲𝘀𝘀𝗶𝘁𝘆 𝗼𝗳 𝗰𝗼𝗻𝘀𝘁𝗿𝘂𝗰𝘁 𝗮𝗻𝗱 𝗲𝘅𝘁𝗲𝗿𝗻𝗮𝗹 𝘃𝗮𝗹𝗶𝗱𝗶𝘁𝘆 𝗳𝗼𝗿 𝗰𝗮𝘂𝘀𝗮𝗹 𝗶𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 📅 When: Wednesday 8th July, 3pm (BST) Sign up here: rb.gy/8ptyey @jessiebaldwin.bsky.social @reproducibilitea.org @ukrepro.bsky.social

Evaluating anonymized genome re-identification using polygenic predictions and its implications for data privacy https://www.biorxiv.org/content/10.64898/2026.06.10.731306v1

How reproducible is cohort research? 🔍📊 Join us to find out from Laurie Hannigan at UCL/UNIL ReproducibiliTea 🫖 📅 23rd April, 1pm BST / 2pm CEST www.eventbrite.co.uk/e/transparen... @tabeasch.bsky.social @reproducibilitea.org @ukrepro.bsky.social @swissrn.bsky.social @uclopenscience.bsky.social

Transparency in epidemiological cohort studies, with Dr Laurie Hannigan

Laurie Hannigan will present a case study on improving transparency and reproducibility in epidemiological cohort research

eventbrite.co.uk

Me & @aysuo.bsky.social are hiring a postdoc to study gene–environment interplay in health & social inequalities 🧬 You'll analyze genomic data as part of a collaboration with Uppsala & Oslo at @amsterdamumc.bsky.social (NL) werkenbij.amsterdamumc.org/en/vacatures... Please RT for karma points ♥️

Our new preprint “Learning lifetime disease liability reveals and removes genetic confounding in electronic health records” is now online! Link to paper: This work is led by my postdoc Yazheng Di and it’s our first project at @bsse.ethz.ch :) medrxiv.org/cgi/content/... Thread 1/n

Learning lifetime disease liability reveals and removes genetic confounding in electronic health records

Electronic health records (EHRs) have become the cornerstone of population-scale genetic studies1, but factors including patterns of healthcare use shape which and how diagnoses are recorded, leading ...

medrxiv.org

🚨 Our new meta-analysis on the causal influence of parenting on disruptive behaviour (DBDs) is now published in Psychological Bulletin. Across 45 quasi-experimental (QE) studies (N ≈ 38,600), we find a small but causal effect of negative parenting on DBDs.

Can AI be used to evaluate open science practices? 🤖🔎 Join us to find out from Dr Daryl Lee at the next ReproducibiliTea! 🫖 📅 Jan 13th, 3pm GMT www.eventbrite.co.uk/e/evaluating... @tabeasch.bsky.social @uclopenscience.bsky.social @uclpals.bsky.social @reproducibilitea.org @ukrepro.bsky.social

How many preregistered studies end up in the file drawer? 🗂️ Join us to find out from Eline Ensinck at the next ReproducibiliTea! 📅Nov 25, 3pm GMT www.eventbrite.co.uk/e/are-prereg... @tabeasch.bsky.social @reproducibilitea.org @uclopenscience.bsky.social @ukrepro.bsky.social @lakens.bsky.social

Are Preregistered Studies Publicly Shared? With Eline Ensinck

Eline Ensinck will present research on the number of preregistered studies which are never published and the reasons behind this

eventbrite.co.uk

Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social

I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health. 3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science! 🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...

Research Fellow in Mental Health at UCL

Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

jobs.ac.uk

When is it appropriate to deviate from a pre-registration, and how should this be done? 🧐 Join us to find out from Daniël Lakens @lakens.bsky.social at the next ReproducibiliTea! October 28, 1pm GMT. Sign up: www.eventbrite.co.uk/e/when-and-h... @tabeasch.bsky.social @reproducibilitea.org

When and How to Deviate From a Preregistration, with Prof Daniël Lakens

Prof Daniël Lakens will share guidance on appropriate circumstances and methods for deviating from a pre-registration

eventbrite.co.uk

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. www.biorxiv.org/content/10.1...

Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

Institute for Behavioral Genetics (IBG)@ibg.colorado.edu · 12mo ago

New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

Design and model choices shape inference of age-varying genetic effects on complex traits

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

shorturl.at

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

READING RECOMMENDATION 📖 Genes, environment, and aging: What determines cognitive and physical decline? Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications

The genetics of human aging remains poorly understood due to limited longitudinal data. Here, the authors show distinct genetic architectures for baseline function and decline in cognitive and physica...

nature.com

🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource. Spread the good news! osf.io/preprints/os...

🧠🧬🧑‍🤝‍🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟 A short thread summarising the study👇

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications

Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Bioban...

shorturl.at

On June 6th, I'll be giving a keynote talk at the Swiss Federal Office for Public Health! It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉 Join if you can! ☺️

Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n

Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...

nature.com

Very excited to give a virtual talk as part of the @eshg.bsky.social webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...

Come work with us! We're looking of postdoc(s) with experience in bacterial genomics and interest in mathematical modelling to work on bacterial ecology and evolution in the context of public health. tinyurl.com/n34vzszu

The recording of the second episode of our #ESHG Webinar Series is now on YouTube. 🔜 Episode 3 – April 30, 16:00 CEST 📌 "Making sense of genetic associations" 🎙️ Zoltan Kutalik Join for free on Zoom! Register here: buff.ly/l6d0fai

We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊 Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs. www.nature.com/articles/s41...

Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood - Nature Communications

Parental neuropsychiatric traits relate to children’s emotions and behaviours beyond genetic transmission alone. Here the author's findings suggest potential environmental risk factors that can act on...

nature.com

Join us in Lausanne for a newly launched Computational Biology Symposium with a stellar lineup of speakers! Registration and abstract submission open: share your original research work in a friendly atmosphere!

Giovanni Ciriello@ciriellolab.bsky.social · last yr.

After 6 (healthy) months of hiatus from social media, first post with a brand new conference announcement!! 🔥COMPUTATIONAL BIOLOGY IS EVERYWHERE! Join us in Lausanne for the first international Computational Biology Symposium! 18-19 September 2025 Registrations are OPEN! cbiosymposium.unil.ch