Sarah Robinson

@robinsonsci.bsky.social

Group Leader Sainsbury Lab Cambridge University. Interested in plant development and biomechanics.

✨ Mark your calendars! ✨ The Plant Computational Biology Workshop 🌱💻 is back—10th edition! 🎉 Sept 7–11 | Lyon, France | FREE ✓ Registration mandatory Limited to 70 researchers (spots filling fast!) Learn more & Register : pcbw.inria.fr

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Supercoiling not only brings DNA to life (and makes it dance) but also changes how key proteins such as #CRISPR interact with it. Thanks @qmsmith.bsky.social for the brilliant collaboration, Sylvia for developing an amazing new #imageanalysis pipeline & @eddierollins.bsky.social for beautiful #AFM.

CryoEM and AFM images of DNA minicircles bound to CRISPR Cas9
Quentin Smith@qmsmith.bsky.social · 4mo ago

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

Thrilled to have our paper out in @science.org. Cell division guides plant cell wall formation. Does the reverse hold? We show that bimodal pectin methylesterification, via PME5 mRNA nuclear sequestration, influences plant cell division and cell plate orientation. www.science.org/doi/10.1126/...

Cell wall patterning regulates plant stem cell dynamics

The plant cell wall regulates development through spatiotemporal modulation of its chemical and mechanical properties. Pectin methylesterification is recognized as a rheological switch controlling wal...

science.org

Roses don’t just defend themselves. Their prickles are geometrically ideal for gripping surfaces, supporting vertical growth, and, when needed, creating lacerations that deter herbivores. Students - join us to investigate how biological form and physical law work together!

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While the first image showed the outside edge of surface mature Arabidopsis root cell, this second image from the same experiment shows the border between two root cells. The large plastid (blue due to chlorophyll autofluorescence) is squashed between the two membranes. #arabidopsis #cellbiology

The image shows two straight magenta lines running in parallel. On either side of them, there are two wavy green lines. The oval-shaped blue chloroplast is squished between one magenta and one green line.