Collecting recent-ish papers for a Cell Bio 101 course I'm teaching this fall. Ideally microscopy-driven breakthroughs that are also experimentally elegant and well written. Any favourites I should check out? 🔬

🎉 *extremely* excited to share our human single neuron + movie dataset is out in #ScientificData! 📄 Human neuron activity during an 83-minute movie from 2,286 neurons and 29 patients 🔗https://www.nature.com/articles/s41597-026-07955-0 1st public dataset from @humansingleneuron.bsky.social!🧵

A minimal lipid kinase/phosphatase system, two effector proteins from Legionella pneumophila, self-organizes together with its lipid substrates (PI/PI3P) into dynamic patterns on membranes. Check out our preprint: www.biorxiv.org/content/10.6...

www.biorxiv.org/content/10.6... Layered helical order reveals assembly states in podosome actin networks

Microscopy Nodes 3.1 is out for Blender 5.2! 🎉 This has cool new features for conditional masking, working with even larger data (regional upscaling), and data manipulation! Watch the new youtube tutorials that explain the features: www.youtube.com/playlist?lis...

Do you want to learn more about OME-Zarr viewers, where they stand today and what's being developed at the moment? On August 24th at 4pm CEST, we will hear about 3 different OME-Zarr viewers and user stories for each. www.biovisioncenter.uzh.ch/en/events/Up... (1/5 🧵)

Open Bioimaging Practices Meetup August 2026

biovisioncenter.uzh.ch

I should also point out that there are other *excellent* steps in the "smart microscopy" + optogenetics direction, including recent efforts by the Pertz and Kapitein labs, that are reviewed here. Take a look! www.degruyterbrill.com/document/doi...

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

Optogenetics equivalent of the "IBM written in atoms" AFM image: hinderling.github.io/assets/pertz... (from hinderling.github.io)

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

🧪 @aicjanelia.bsky.social and @scientistrachel.bsky.social have just published a new quantitative tool, OpticalFlow3D, for tracking amorphous motion in 3D. Try it out and let us know what you think! tinyurl.com/OpticalFlow3D

How do you know if a microscopy experiment can actually resolve a biological structure? Introducing VLab4Mic, a platform that predicts structural resolvability before you go to the microscope Led by Damián Martinez and Bruno Saraiva at @henriqueslab.bsky.social www.biorxiv.org/content/10.6...

How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

Our thread is now up at @epimechfc.bsky.social 💗 Take a look if you are interested in how a living tissue knows how to sculpt itself!

epithelial mechanics fan club@epimechfc.bsky.social · 4mo ago

How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

How do epithelial cells integrate mechanical and biochemical signals to control their behavior? I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.

Make your own PDMS+micromirror device for single-objective light-sheet SMLM: www.biorxiv.org/content/10.6...

It's funky axons time 🔬 🧪

say hello to Laurent! just started his PhD, and new on bluesky. cloning-wizzard and optogenetics-guru, using microscopy to link signaling & mechanics

Laurent Dubied@laurent-dubied.bsky.social · 4mo ago

Spinning spheroids on 40 µm circular patterns. Recent work from @olivierpertz.bsky.social lab!

📣 Submission deadline extended for special issue "Taking the Stage: The Future of Microscopy"! The Journal of Microscopy has launched an open call for papers for an exciting new special issue which will feature submissions by Early Career Researchers. Deadline extended: 30 April 2026

🚨📰Now online in its full form www.nature.com/articles/s41...

FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing - Nature Communications

Tracking fast molecules in crowded organelles is error-prone, obscuring dynamic processes like Alzheimer’s secretase activity or secretory sorting. Here, authors present FidlTrack, a structure-aware m...

nature.com

Avezov lab@avezovlab.bsky.social · 6mo ago

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule rdcu.be/e3Ris

Hi all fans of #smart #microscopy, we from @zeiss-microscopy.bsky.social have just published a new application note: "Study Mitotic Progression with Guided Acquisition – Rare Event Detection" go2.zeiss.com/ODk2LVhNUy03... For more details: forum.image.sc/t/applicatio...

Recording of talk for the french bioimaging network RTmfm. My PhD work in @olivierpertz.bsky.social lab (closed-loop optogenetics, microfabrication, image analysis w/ Convpaint). On smart microscopes: the issue of interoperability and some preliminary results on LLM control :) youtu.be/Gvaw2kWsVIk

Smart microscopy for automation of optogenetic targeting

YouTube video by miti rtmfm

youtu.be

Such an intriguing concept for the future of smart microscopy, especially appreciate how the paper builds on the foundations of knowledge creation, rather than arguing from a technolocial perspective first!

🔬 In this new open access paper, the authors introduce a theoretical framework that reconceptualises smart microscopy as a partner in scientific investigation. Central to their framework is the concept of the ‘epistemic–empirical divide’ in cellular investigation, ...

Open Blink: Low-cost TIRF microscopy for super-resolutionimaging via μManager https://www.biorxiv.org/content/10.64898/2026.03.10.710894v1

Excited to see direct streaming of @openmicroscopy.org @zarr.dev datasets in #syGlass! Exploring huge images without upfront download is just what we’ve been working toward with cloud-optimized formats. Great to have tools connecting the ecosystem of imaging repositories, now including VR 🙌

Brandy A Freitas@brandy-syglass.bsky.social · 5mo ago

Streaming OME-Zarr data directly into syGlass for #3DThursday🌍🔬 With #syGlass v2.6.0, datasets can stream from disk, S3, or HTTPS with no massive downloads required. Huge thanks to the community building open imaging standards: @openmicroscopy.org #OMEZarr #Microscopy #OpenScience #Bioimaging

Check out and give feedback on the latest pre-release 0.7.0rc0! You can install with `pip install "napari[all]>=0.7.0rc0"` or via the bundled app. 😁 🥳 The release notes, with highlights, include so many great new features and changes: napari.org/dev/release/...

napari 0.7.0

⚠️ Note: these release notes are still in draft while 0.7.0 is in release candidate testing. ⚠️ Tue, Mar 10, 2026 We’re happy to announce the release of napari 0.7.0! napari is a fast, interactive,…

napari.org

Tiny, transparent, and now charted! Our brain atlas of adult Danionella cerebrum includes >200 annotated regions, 29 whole-brain in situs, and male/female reference volumes – openly available, versioned and extendable. Work by @nkadobyansky.bsky.social and team. www.biorxiv.org/content/10.6...

Calling for protocols on The Basics: get a protocol recorded and peer reviewed, and help a colleague learn the tips and tricks by *seeing how it's done* You don't need to include new results and it does not have to be your original protocol. Just cite well and share the know-how 💕🔥 Get in touch!

Marija Matejčić (mateytch-itch)@marija-matejcic.bsky.social · 8mo ago

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech

napari needs your help! Has napari helped you make cool and groundbreaking discoveries? We'd love to highlight that in our docs. Please tell us about it! You can fill in this survey: napari.typeform.com/to/vTCKeTKv and/or, as ever, drop by our chat room or meetings: napari.org/dev/community/ 🙏