Super excited to host Ruslan Rust @rrust.bsky.social next week for our Seminar Series at the Ottawa Hospital Research Institute. Can't wait to hear about his amazing science! #Seminar

We update our preprinted LLM analysis of preprint-to-publication transitions in 72644 pairs Expand human validation Consider preprints never published Impacts of preprint-to-publication interval www.biorxiv.org/content/10.6... Kudos to @rrust.bsky.social & team😎 Appreciate the community's input🙏

Enzyme-free isolation of mouse brain/cortex vasculature for proteomics glass Dounce homogenizer 70 kDa dextran density-gradient centrifugation (you don't need ultracentrifugation) 30–80 μg total protein yield per adult mouse @rrust.bsky.social #STARProtocols 2026 www.cell.com/star-protoco...

Nature News covered our preprint on LLM analysis of Preprint-to-Publication transition 😆👇 Think preprints are unreliable? Analysis of 70,000 studies might change your mind www.nature.com/articles/d41... Kudos to @rrust.bsky.social for leading this project👍 www.biorxiv.org/content/10.6...

www.biorxiv.org/content/10.6...

Vascular and synaptic proteomes reveal blood-brain barrier disruption and postsynaptic remodeling in human temporal lobe epilepsy

Blood-brain barrier (BBB) dysfunction and mesial temporal lobe epilepsy (MTLE) are considered to be engaged in a pathological feedback loop, with the consequent worsening of both conditions. However, ...

biorxiv.org

🧠 New funding opportunity for all scientists working on brain organoids 🧠

Neutrophil-neuronal crosstalk drives arthritis-induced pain www.researchhub.com/paper/106078...

Neutrophil-neuronal crosstalk drives arthritis-induced pain

Pain in rheumatoid arthritis (RA) often persists despite effec...

researchhub.com

New study shows that TGFβ signaling is crucial for maintaining microglial resilience to myelin degeneration during aging. This highlights a previously unresolved checkpoint of TGFβ signaling with regional specificity and spatially restricted microglia–oligodendrocyte interactions.

Check out the news article about our recent work on cell therapies for stroke by Drug Target Review: www.drugtargetreview.com/news/187869/... More info about the original study can be found here: www.nature.com/articles/s41...

New stem cell approach could repair stroke-damaged brains

Explore the impact of stroke and the latest research on stem cell therapy aimed at improving recovery from ischemic strokes.

drugtargetreview.com

Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis

Eleven clinical trials that will shape medicine in 2026 Happy to see a lot of cell-based therapies!

hiPSC-derived Neural Progenitor Cells support long-term (43 dpi) graft neuronal integration & functional recovery after photothrombotic Stroke🐭 👉57% neurites extend along cc into contralateral hemisphere Grafts▶️44% GABAergic Neurons @rrust.bsky.social #NatComm 2025 www.nature.com/articles/s41...

CleLight: A scalable 3D histology pipeline for mappingneurodegenerative and psychiatric pathology in archivalhuman brains www.researchhub.com/paper/105900...

CleLight: A scalable 3D histology pipeline for mappingneu...

Mesoscopic brain imaging, enabled by advances in tissue cleari...

researchhub.com

“Time is brain” for cell therapies?🧠 Our #AdvSci perspective😆 @rrust.bsky.social @dominikusbrian.com @lydenlab.bsky.social #StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock advanced.onlinelibrary.wiley.com/doi/10.1002/...

New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!

Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s. Makes me also wonder how many could be druggable targets.

Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.

Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbM–cortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social

The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes. These findings link vascular risk and Alzheimer’s mechanisms.

Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response www.mdpi.com/1422-0067/26...

Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinson’s disease treatment! cell.com/cell-stem-ce...

Great study dissecting molecular hallmarks of neuronal resilience in Alzheimer’s disease highlighting natural protective mechanisms that could help preserve cognition. x.com/rust_ruslan/...

Can stem cells help to regain brain function after stroke? Our new study in NatureComms @natureportfolio.nature.com shows that they can and dissect the key mechanisms driving recovery. t.co/KRfAHfkNIH

Effects of psilocybin and related compounds on neuroprotection in human stroke www.researchhub.com/fund/4261/ef...

Effects of psilocybin and related compounds on neuroprote...

Effects of psilocybin and related compounds on neuroprotection...

researchhub.com

Delayed Transplantation (7 vs 1 dpi) of #NeuralStemCell Improves Initial Graft Survival after #Stroke ⏫graft axon extension along #CorpusCallosum to contralateral hemisphere @ctackenberg.bsky.social @rrust.bsky.social #AdvSci 2025 advanced.onlinelibrary.wiley.com/doi/10.1002/...

"Authentic" #hiPSC-derived #Pericyte 😎 Sharing highly similar proteome/phosphoproteome to primary👤🧠cortical pericyte Contractile ⏫ #BloodBrainBarrier & Neuroprotective (Pdgfrb F7/F7🐭) Clear Aβ Tau (🧠slices 5xFAD🐭 APOE4 P3001S🐭) @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

#hiPSC derived #Pericyte 👉>80% Home to & >50% Arborize on Capillaries in live🧠slice of PdgfrbF7/F7🐭 in situ PDGFBB-PDGFRβ PLA assay😍 👉⏫Amyloidβ clearance on 10-m/o 5xFAD 🐭🧠slice Are these phagocytic pericytes still vessel-bound?😁 @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...

#Medsky🧪 #Neurosky Much of stroke research focuses on acute injury - but what changes in the brain one month after stroke? By @rrust.bsky.social et l link.springer.com/article/10.1... www.researchhub.com/paper/938498...

Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma. Wonder if these NSCs exist in humans & can show similar therapeutic potential www.nature.com/articles/s41...

Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system - Nature Cell Biology

Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...

nature.com