So et al. show that the benefits of baricitinib in recent-onset type 1 diabetes wane after treatment cessation, with β-cell function no longer significantly preserved at 96 weeks, suggesting that durable effects may require continuous treatment. diabetesjournals.org/care/article...

Thrilled to have presented our poster on Gαs deletion in the pancreas at #EISG2026! 🧬 Excellent discussions with @akermanlab.bsky.social, @lorenzpasquali.bsky.social & Jorge Ferrer — plus great chats over dinner. Our preprint is on bioRxiv! 👇 doi.org/10.64898/202... #IsletResearch #Pancreas

The #EISG2026 meeting was also a memorable reunion for those of us who trained with @jorge-ferrer.bsky.social — such a fantastic opportunity to catch up with the old crew, timonel included! 🧬👥 @akermanlab.bsky.social @lorenzpasquali.bsky.social @diegobalboa.bsky.social @txellrovira.bsky.social

That's a wrap on #EISG2026 in Barcelona! Three incredible days of islet science, from genomics to clinical translation. Grateful for the talks, discussions, and community that make this meeting so special. Thanks to @lorenzpasquali.bsky.social and @txellrovira.bsky.social for putting this together!

All pieces are in place to launch our vascularized pancreatic endocrine organoid-on-a-chip platform—excited to build this out with Oscar and Romen. Let's move this collaboration forward!

Great meeting with Josep Samitier, co-founder & former director of @ibecbarcelona.eu , now leading Fraunhofer Spain. Exploring Argentina-Spain collaboration for our vascularized pancreatic organoid platform. Thanks, Josep!

It was a pleasure to present the results of our work @ifibyne today at @ibecbarcelona.eu Thank you Elisabeth, Oscar and Romen for the invitation! Thanks also @ubaglobal and the Erasmus+ Programme for funding.

Reading this makes adrenaline spike... which so far makes the difference with AI. Dystopian or not, who should decide how to handle this and how much power to trust? www.nature.com/articles/d41...

Too dangerous to release: is Mythos the start of the restricted-AI era?

What happens when AI companies produce models that they say the public can’t have — and how should users and governments react?

nature.com

“It absolutely defied all of our expectations. This was so surprising that my whole project changed.” This phenomenon could have far-reaching implications, and is leaving neuroscientists baffled. go.nature.com/4wEzuzH

The brain’s code seems to be in constant flux. Neuroscientists are baffled

Nature - Neurons fire much more erratically than researchers thought. What does that mean for how the brain works?

go.nature.com

Nature research paper: Expanding the human proteome with microproteins and peptideins go.nature.com/4ttILbi

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

go.nature.com

El lunes 27/4 a las 12:30 h doy una charla en el ciclo del @InstitutoInigem 🧬 *Control Epigenómico del Desarrollo y Destino de la Célula β Pancreática* Desde la mesada a la *Iniciativa Argentina de Genómica en Diabetes Tipo 1 (IG-DT1)* Virtual y abierta. ¡Los/las espero!

Congrats, Lic. Zelicovich, on your successful thesis defense last Friday! 🎓 It was a pleasure directing your work at @ifibyne. Looking forward to new projects together as you start your PhD in our lab—especially on the T1D genomics initiative. Great work, Martín!

🧵 New preprint! Whole-pancreas Gαs knockout reveals profound exocrine defects, YAP activation, and attempted β-cell regeneration from ducts in the context of severe diabetes. GPCR atlas + PGsKO characterization. 👉 doi.org/10.64898/202... #Gαs #Diabetes #βcells #GPCRs #pancreas

Congratulations Dr. Olszanowski @eve_olsza on the successful defense of your PhD thesis last Friday! 🎓 It was a pleasure to have co-directed you in this exciting project @ifibyne. All the best in your next steps! 👏

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Few days left to join our ambitious and innovative program using human induced pluripotent stem cells derived hepatocytes for cell based therapies against liver diseases. We are looking for 2 motivated, ambitious and determined technical assistants. karriere.charite.de/stellenangeb...

🎉 Our editorial "Advances in β-cell Development & Regeneration" is now published in @frontiersin.bsky.social! We explore restoring functional β-cell mass for diabetes therapy. Thank you to all authors. Read & share: doi.org/10.3389/fend... #diabetes #regenerativemedicine #betacells

Frontiers | Editorial: Advances in β-cell development & regeneration

This is a provisional file, not the final article pathogenesis of diabetes mellitus is fundamentally linked to a decline in pancreatic β-31 cell mass (1). Re...

frontiersin.org

Great farewell-to-2025 meeting for the lab! It was a challenging year, but we're ready for a great 2026!

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study + past & current team @labspagnoli.bsky.social + collaborators #VigilanteLab @kingslsm.bsky.social ➡️ doi.org/10.1126/scia... short 🧵 below & more acknowledgments ⤵️

Spatially organized cellular communities shape functional tissue architecture in the pancreas

Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.

doi.org

“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪 Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis". www.science.org/content/arti... @science.org @sciencecareers.bsky.social #ScienceWorkingLife #AcademicChatter #AcademicTwitter #ScienceTwitter

Science Magazine@science.org · last yr.

"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0

Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link! www.nature.com/articles/s41...

A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors - Nature Neuroscience

The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuati...

nature.com

Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM

Can amylin-based drugs upstage GLP-1 agonists?

Nature Biotechnology - Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1...

rdcu.be

Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...

A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications

Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...

nature.com

💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year. However, one death due to the immunosuppressive treatment. buff.ly/ZI14m2i

¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina! www.agenciatss.com.ar/una-hormona-...

Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!

Santiago Rodríguez Seguí@rseguilab.bsky.social · last yr.

Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

nejm.org

Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!

Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!

Santiago Rodríguez Seguí@rseguilab.bsky.social · last yr.

Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!