I just still cannot help myself from looking that these beautiful real-time dynamics videos from @anjbadri.bsky.social lab! thanks to all the authors from @joeloparo.bsky.social / @anjbadri.bsky.social and TJ Ha labs.

Miloš Tišma@tismaa.bsky.social · 2w ago

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

Chromosome topology gates productive RecA homology search

In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How dynam...

biorxiv.org

So thankful for winning the Poster Prize at @fusionconf.bsky.social in Prokaryotic Cell Biology for my research on the effects of chromosome topology on DNA repair! Looking forward to developing the work further and sharing more soon !! 🤩🤩

Honoured to receive a talk prize at the Fusion Conference on Prokaryotic Cell Biology in Lisbon last week. Thank you to the organisers for a wonderful meeting, and to all the scientists whose ideas continually help me grow! @fusionconf.bsky.social #ProkaryoticCellBio #scienceisbeautiful

In the last steps of the manuscript writing and I just ran the full document through the new @qedscience.bsky.social "Meet the 1%" manuscript comparison... I am beyond excited to share my postdoc work from @joeloparo.bsky.social lab in the next few weeks! 🤩🤩

Outstanding work from @jovanakaljevic.bsky.social as together with the team they explore the depths of ParB world🤩 On my list!

Jovana Kaljević ⬜️@jovanakaljevic.bsky.social · 8mo ago

Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it. www.pnas.org/doi/10.1073/...

Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it. www.pnas.org/doi/10.1073/...

Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS

Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states thro...

pnas.org

Wow, what an honor! The @biophysicalsoc.bsky.social awards me the esteemed '2026 Kazuhiko Kinosita Award in Single-Molecule Biophysics' 'for groundbreaking contributions to the field of nanobiology and single-molecule biophysics, from nanopores to SMC molecular motors'. Feel honored, very thankful!

Absolutely preposterous size of a Giant Sequoia…

Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports... In an exemplary in vitro/in vivo study, 1st authors ‪@btanalikwu.bsky.social‬ & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs! Great collaboration with Marcand lab.

Wrapped up a GRC on Bacterial Cell Biology and Development last week in SNHU, New Hampshire. A full week of talks on novel bacterial systems and new mechanistic details on eastablished systems. Great chance to learn, connect with peers and enjoy science!

We're excited to host two fantastic speakers at our next online @physicsoflifeuk.bsky.social ECR Seminar on Tuesday 15 April, 2–3 PM BST: Tisma Milos and Thomas McLean chaired by @veronicabiga.bsky.social Please register below for the Zoom link: lnkd.in/dSynrAe8

Just watched a podcast with Jiankui He, the first person to go. through with CRISPR editing in human babies in 2018. He started a complex debate (both in productive and destructive ways) on ethics in science, future of gene editing and safety of current methods.

 www.youtube.com/watch?v=ch03...

The Man Who Used Gene Editing On Babies - Jiankui He

YouTube video by BioAcc Podcast

youtube.com

A lovely visit to Yale School of Medicine to see @leoschaerfen.bsky.social graduate with a spectacular PhD work. 🤩

Biologist-"Let me order some Biotin-11-dUTP" Chemist-"Let me order some ((2R,3S,5R)-5-(2,4-dioxo-5-(3-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate" 😅

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

Fernando Rossine@fernpizza.bsky.social · last yr.

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...

Nice to see that Science(.org) supports and spreads awareness of the massive protests currently ongoing in Serbia! Peaceful protests lead by Serbian University students (later joined by many others), have gathered more than 200 000 people on occasions! www.science.org/content/arti...

Scientists rally in support of Serbia’s anticorruption protests

But some criticize “weak and formal” support for protests from scientific institutions

science.org

This is so real 🤣🤣 I do not know the explanation of this but definitely resonates very well…

What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties? We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)

Jan Huertas@janhuemar.bsky.social · 2y ago

Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social www.biorxiv.org/content/10.1...

Congrats to #CDlab graduate ‪Miloš Tišma for winning a Rubicon grant to pursue postdoc research on antibiotic resistance at Harvard Medical School!

Miloš Tišma@tismaa.bsky.social · 2y ago

Glad to receive the trust and recognition in being awarded a Dutch NWO Rubicon Fellowship for important work on antibiotic resistance. I will be tackling this problem using a combination of biophysics, biochemistry and microbiology in Joe Loparo lab at Harvard Medical School (Dept. of BCMP).

Glad to receive the trust and recognition in being awarded a Dutch NWO Rubicon Fellowship for important work on antibiotic resistance. I will be tackling this problem using a combination of biophysics, biochemistry and microbiology in Joe Loparo lab at Harvard Medical School (Dept. of BCMP).

About the price of a hefty GPU workstation, close to a student’s annual consumables cost in the lab, attendence to 5 conferences, full week of Krios data collection, cost of ~100 samples for proteomics data collection… so many things to better spend the money than these outrageous publishing fees.

Cees Dekker@ceesdekker.bsky.social · 2y ago

oefff, paying 11253 euro as open access fee for publishing a single paper in Cell (@cp-cell.bsky.social) - that's an outrageous amount of money.

The truth is nobody should care how many protein coding genes there are. The gene is a useful abstraction that loses its utility when defined precisely enough to count.

Veera Rajagopal@doctorveera.bsky.social · 2y ago

Exactly how many protein-coding genes are there in the human genome? The truth is no one knows. The numbers change based on what database you use as reference.

This will be me in a few months when i come back @btanalikwu.bsky.social and Jaco 🤣🙈

Oded Rechavi@odedrechavi.bsky.social · 2y ago

Revisiting the lab where you did your post doc and meeting your bench mates who're still there

I hope this can inspire and motivate someone that distances that are often expected to happen as you walk your path through science, do not have to be harmful to your relationships and friendships ☺️

Miloš Tišma@tismaa.bsky.social · 2y ago

Nice to be featured in @natureportfolio.bsky.social Career Column for our personal story on how we kept in touch over the years. From undergrad -> MSc -> PhDs and beyond We added science to our friendships and in turn our friendships to our science! doi: doi.org/10.1038/d415...

Nice to be featured in @natureportfolio.bsky.social Career Column for our personal story on how we kept in touch over the years. From undergrad -> MSc -> PhDs and beyond We added science to our friendships and in turn our friendships to our science! doi: doi.org/10.1038/d415...

Raising a glass to the Four Friends Doing Science journal club

Four researchers who left Serbia to pursue their careers rely on this group to keep in touch and to navigate life in science.

doi.org

Out today in Nucleic Acids Research! My final publication from @ceesdekker.bsky.social lab together with A.M. Gonzalez ! Together with @gruberlab.bsky.social in Lausanne, we show the interaction between supercoiled DNA and partitioning protein ParB. Read full: doi.org/10.1093/nar/...

Latest #CDlab paper in Nucleic Acid Research: academic.oup.com/nar/article/... Great work by Alejandro Martin-Gonzalez, @tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.

AMR awareness week ends today, but still something to keep in mind always! www.who.int/campaigns/wo...

World Antimicrobial Awareness Week 2024

World Antimicrobial Awareness Week aims to increase awareness of global antimicrobial resistance (AMR) and to encourage best practices.

who.int