Samuel Pattillo Smith
@sampatsmith.bsky.social
Postdoc with @arbelharpak.bsky.social. Popgen and complex traits. All views and opinions are my own. he/him
I am excited to share my first paper, our new preprint: www.biorxiv.org/content/10.6... with @arbelharpak.bsky.social and @docedge.bsky.social. Family GWAS provides direct genetic effect estimates and is increasingly important. But how much can we trust these estimates? (1/15)
biorxiv.org
Excited to share our new preprint from the @arbelharpak.bsky.social Lab! How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21) www.biorxiv.org/content/10.6...
Representation in genetic studies affects inference about genetic architecture
Knowledge of a trait's "genetic architecture," namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding it...
biorxiv.org
New work from my lab, led by graduate student Janis Liu. Janis studied type I error rates in Qst/Fst comparisons (1/n) www.biorxiv.org/content/10.1...
Error rates in Q_ST--F_ST comparisons depend on genetic architecture and estimation procedures
Genetic and phenotypic variation among populations is one of the fundamental subjects of evolutionary genetics. One question that arises often in data on natural populations is whether differentiation...
biorxiv.org
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...
biorxiv.org