Lab-evolved proteins often sacrifice stability to gain function. David Liu and Nicholas Krasnow of @broadinstitute.org used AI to stabilize proteins before evolving them — and got results 79x better than when they started with a natural protein. www.broadinstitute.org/news/combini...

Combining AI with laboratory evolution yields improved proteins

Researchers found that AI-redesigned versions of natural proteins serve as superior starting points to evolve proteins with new functions.

broadinstitute.org

Separating rare earth elements usually requires massive amounts of toxic solvents. A new method from @uchicagopme.bsky.social, Argonne, & Northwestern scientists, described today in @natchemeng.nature.com, instead uses water, squeezing ions through layered channels. pme.uchicago.edu/news-events/...

Colorectal cancer is now the top cause of cancer deaths under 50. @shrutipatelmd.bsky.social of @stanfordmedicine.bsky.social just formed an early-onset GI cancer clinic. I asked her & other Stanford experts what they wish young people knew about these cancers. med.stanford.edu/news/insight...

Colorectal cancer's rise in adults under 50: What you should know

Colorectal cancer is the No. 1 cause of cancer deaths among people under age 50. Here’s what Stanford Medicine experts want people to know.

med.stanford.edu

So pleased that the "What the Science Says" series I've worked on for @stanfordmedicine.bsky.social has won a 2026 CASE Award! Also recognized was a recent issue of UCSF Magazine which I have a feature in. Always grateful to be able to work for such quality publications! www.case.org/awards/circl...

What the Science Says: Stanford Medicine Experts Parse the Facts

See more about this award-winning entry.

case.org

Fentanyl kills more Americans each year than car accidents and gun violence combined. @scripps.edu's Kim Janda is developing a vaccine that intercepts it before it reaches the brain — and works against designer drug variants that don't even exist yet. www.scripps.edu/news-and-eve...

A fentanyl countermeasure that adapts to combat future black-market drugs

scripps.edu

A microscope at @gladstoneinst.bsky.social is on the search for new Parkinson's treatments. It designs its own experiments, runs thousands simultaneously on individual cells, learns from the results, and repeats-- without guidance from scientists. gladstone.org/news/how-ai-...

How an AI Microscope Is Learning to Do Science

Gladstone scientists have developed a thinking microscope that can conduct its own experiments, with the ultimate goal of treating neurodegenerative diseases.

gladstone.org

For the first time, a vaccine reliably produced broadly neutralizing HIV antibodies in every animal tested. @scripps.edu & @ki.se researchers targeted the apex of HIV's spike, a region nearly identical across hundreds of thousands of strains. www.scripps.edu/news-and-eve...

Experimental HIV vaccine achieves a long-sought goal

scripps.edu

How does the brain drain its waste? A new method developed at @gladstoneinst.bsky.social maps the routes proteins takes out of the brain. The result: unexpected biology, and new insight into how disease disrupts the brain's cleanup system. gladstone.org/news/mapping...

Mapping How the Brain Takes Out Its Trash

Gladstone scientists developed a new tool to trace how the brain clears “waste,” uncovering surprising new biology about how it keeps itself healthy.

gladstone.org

At @columbiamed.bsky.social, scientists are no longer betting everything on a single, simple explanation for Alzheimer's. Instead, they are mapping the subtypes, the way oncologists once did for cancer, to finally develop targeted treatments. www.vagelos.columbia.edu/about-us/col...

A New Blueprint for Alzheimer’s

Approaching Alzheimer’s from every angle, Columbia scientists are finding unexpected inroads to this complex disease and forging paths to new treatment possibilities.

vagelos.columbia.edu

Ventricular fibrillation moves so fast that sending cardiac data to a remote server takes too long to save a life. A new skin-like AI computing patch from @SihongWang_UChi @UChicagoPME runs the analysis in milliseconds, directly on the body. pme.uchicago.edu/news/researc...

Researchers develop AI-powered stretchable computing patch

A new fabrication method enables large-scale stretchable transistor arrays to run AI algorithms directly on the body, without transmitting data to an external computer

pme.uchicago.edu

Scientists thought DNA wrapped in nucleosomes was either locked away or accessible, on or off. "It's more like a volume dial," says @gladstoneinst.bsky.social's Vijay Ramani. An AI tool described in @nature.com found 14 nucleosome states- a new layer of genomic grammar. gladstone.org/index.php/ne...

AI Discovery Reveals DNA Isn’t Locked Away in Cells After All

A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.

gladstone.org

ChatGPT learned language from millions of texts. @gladstoneinst.bsky.social's Geneformer learned the language of human genes from 100 million cells. Now, it can predict which genes to target to fix diseased cells. My latest for a Gladstone series on science & AI: gladstone.org/news/how-ai-...

How AI Is Pointing Scientists in New Directions and Leading to Novel Drug Targets

Gladstone scientists are developing novel AI models to predict what goes wrong in disease—and how to fix it.

gladstone.org

Brain immune cells stay chronically overactivated in Alzheimer's, destroying synapses. @scripps.edu scientists traced that inflammation to a single chemical modification on one protein. Blocking the modification protects synapses in mice. www.scripps.edu/news-and-eve...

How a chemical reaction triggers brain inflammation in Alzheimer's disease

scripps.edu

Precise bacterial genome editing has been largely stuck in E. coli. Scientists at @gladstoneinst.bsky.social just changed that, showing that their retron-based editing tools work across 15 diverse species of bacteria. gladstone.org/news/univers...

A Universal Toolkit for Editing Bacterial DNA

Scientists at Gladstone expanded their retron-based genome editing technology beyond E. coli, showing it works in 15 diverse bacterial species.

gladstone.org

Carbon capture and CO₂ conversion are usually two separate, expensive steps. @uchicagopme.bsky.social and Argonne scientists combined them into one system that works efficiently even under messy, real-world flue conditions. pme.uchicago.edu/news/researc...

Researchers combine carbon dioxide capture and conversion into one system

The new approach, developed by UChicago PME and Argonne National Laboratory researchers, offers a streamlined and cost-effective pathway toward decarbonization.

pme.uchicago.edu

Most liver cancer is linked to hepatitis viruses, but scientists have never had a mouse model that faithfully tracks the full disease arc from infection to cancer. Now they do, thanks to work out of @rockefeller.edu. www.rockefeller.edu/news/39337-a...

MaxToki, a new AI model developed at @gladstoneinst.bsky.social, learned how every cell type in the body ages. Now, it can predict which genes drive that aging, pointing toward new targets for heart disease and dementia. gladstone.org/news/new-ai-...

New AI Model Predicts How Cells Age

Trained on data spanning the human lifespan, a new tool developed at Gladstone can predict genes associated with aging and age-related diseases.

gladstone.org

Two-thirds of Americans living with Alzheimer's today are women. But are women actually more prone to developing dementia? If so, why? And what can they do about it? I chatted with @stanfordmedicine.bsky.social neurologists to get answers to these questions. med.stanford.edu/news/insight...

Women get Alzheimer’s more often than men: Five things the science tells us

Women develop Alzheimer’s disease at higher rates than men. Stanford Medicine neurologists explain what science knows about why and the many things it doesn’t yet know.

med.stanford.edu

Touch ice or taste menthol, and the protein TRPM8 opens to signal 'cold' to your brain. Scientists spent years trying to catch it in the act of opening. David Julius & Yifan Cheng at @ucsanfrancisco.bsky.social just did — first atomic-level snapshots of cold sensation. www.ucsf.edu/news/2026/03...

How the Body Senses Cold Has Been a Mystery – Until Now

TRPM8, a key cold-sensing protein in nerve cells, activates to send “cold” signals to the brain when exposed to low temperatures or cooling sensations like menthol. New research from UCSF reveals how ...

ucsf.edu

Today in @nature.com: CAR-T therapy costs $400K+, takes weeks, and requires chemo prep. Researchers at @ucsanfrancisco.bsky.social, @gladstoneinst.bsky.social skipped all of that — reprogramming cancer-fighting T cells directly inside the body with a single injection. www.ucsf.edu/news/2026/03...

Scientists Create Cancer-Fighting Immune Cells Right in the Body

UCSF scientists found a precise way to turn on cancer-fighting immune cells inside the body. This more potent form of CAR-T has the potential to treat many more cancers.

ucsf.edu

Right now, molecular machines in your cells are copying your genome, repairing damage to your DNA, and controlling which genes stay on or off. When they fail, the consequences are severe. @rockefeller.edu scientists are studying this machinery of life. seek.rockefeller.edu/the-machiner...

1 in 10 people get kidney stones. For those who keep getting them, treatment options are limited. @stanfordmedicine.bsky.social's Alan Pao is developing drugs to block the formation of some types of recurrent kidney stones. stanmed.stanford.edu/new-drugs-ki...

A search for a drug that will prevent kidney stones from forming

Nephrologist Alan Pao is developing drugs that boost the urine’s citrate, a natural kidney stone blocker, to stop kidney stones from forming.

stanmed.stanford.edu

Current tools remove the toughest stroke clots on the first try just 11% of the time. A tiny spinning device developed at @stanfordmedicine.bsky.social does it 90% of the time, by shrinking clots to just 5% of their original size. stanmed.stanford.edu/tiny-spinnin...

Shrinking blood clots in the brain using a tiny spinning device

A collaboration between an engineer and a stroke specialist led to a spinning device that shrinks blood clots to remove them from the brain.

stanmed.stanford.edu

The gut has more neurons than your spinal cord. @stanfordmedicine.bsky.social researchers Julia Kaltschmidt & Todd Coleman are finally mapping this "second brain" and finding it holds clues to sleep, Parkinson's, IBS, and more. stanmed.stanford.edu/gut-brain-ne...

How to turn energy-storing white fat into energy-burning beige fat? The answer lies in signals produced by your gut bacteria, @broadinstitute.org's @thexavierlab.bsky.social reports today in @nature.com. Mice with the right gut bacteria had more beige fat. www.broadinstitute.org/news/gut-bac...

Gut bacteria rewire fat tissue to burn more energy

Study reveals how the gut microbiome and diet work together to transform white fat cells into energy-burning beige fat in mice.

broadinstitute.org

Inside every cell, DNA is dancing. Stretches loop and twirl until distant sections find each other, touch briefly, exchange information, and spin away. @stanfordmedicine.bsky.social scientists have developed methods to track this choreography & its role in cells. stanmed.stanford.edu/dna-movement...

How DNA movements drive cell functioning

For decades, textbooks depicted our genome as a disordered tangle of strands. Developmental biologist Alistair Boettiger is helping prove that wrong.

stanmed.stanford.edu

Scientists at @rockefeller.edu, led by Junyue Cao, profiled nearly 7 million cells across 21 tissues in mice at three different ages, creating the most comprehensive map yet of how aging reshapes the body. www.rockefeller.edu/news/39031-s...

Children with NAXD deficiency typically die within their first few months of life. @gladstoneinst.bsky.social scientists reported in @cellpress.bsky.social that vitamin B3 therapy extended lifespan more than 40-fold in mice and eliminated symptoms. gladstone.org/news/vitamin...

Vitamin B3 Therapy Offers Hope for Fatal Childhood Disease

A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.

gladstone.org

People living at high altitude have less diabetes. A new study by @gladstoneinst.bsky.social @ishahjain.bsky.social shows why: In low-oxygen conditions, red blood cells soak up sugar from the bloodstream. A drug mimicking this effect reversed high blood sugar in mice. gladstone.org/news/red-blo...

Red Blood Cells Soak Up Sugar at High Altitude, Protecting Against Diabetes

New study shows red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.

gladstone.org

Scientists at @scripps.edu developed Ribo-STAMP to measure protein production in neurons. The method, described in @nature.com, revealed that some memory cells produce proteins at higher rates than others. It could help reveal what goes wrong in diseases. www.scripps.edu/news-and-eve...

Mapping protein production in brain cells yields new insights for brain disease

scripps.edu