Proud of @sarahnaguib.bsky.social for her new co-first author paper in @molneurodegen.bsky.social in collaboration with @blurtonjoneslab.bsky.social & Paz lab. Transplanted iPSC-derived microglia in progranulin KO mice restores pathology, circuitry, & behavior pubmed.ncbi.nlm.nih.gov/42464356/

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice - PubMed

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

pubmed.ncbi.nlm.nih.gov

So excited to share that our collaborative work on microglial replacement in PGRN-deficient FTD mice with @blurtonjoneslab.bsky.social and the Paz lab is out in @molneurodegen.bsky.social 🧠🔬🎉🤗

Molecular Neurodegeneration@molneurodegen.bsky.social · 2mo ago

Transplantation of human #iPSC -derived #microglia ameliorates #neuropathology and circuit dysfunction in #progranulin -deficient mice Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk... Jeanne T. Paz, Mathew Blurton-Jones, Li Gan @liganlab.bsky.social link.springer.com/article/10.1...

Anyone at @isscr.org interested in iPSC-derived microglia cell replacement therapy in Parkinson's Disease, come stop by my poster today at 5:15pm, F1198!!

Online registration for #ISSCR2026 closes on 1 July! Do not miss your chance to join nearly 3,500 stem cell researchers and regenerative medicine professionals from around the world to discuss the latest advances and innovations in the field! invt.io/1bxb3yx4nvp @ISSCR.org

ISSCR 2026 online registration closes 1 July.

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Online registration for #ISSCR2026 closes on 1 July! Do not miss your chance to join nearly 3,500 stem cell researchers and regenerative medicine professionals from around the world to discuss the latest advances and innovations in the field! invt.io/1bxb3yx4nvp @ISSCR.org

ISSCR 2026 online registration closes 1 July.

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Connect with leading scientists, discover groundbreaking research, and take part in countless networking opportunities designed to spark collaboration and innovation at #ISSCR2026! Register for The Global Stem Cell Event to be part of the future of stem cell science! invt.io/1bxboyywjok @ISSCR.org

Network with stem cell leaders at ISSCR 2026.

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From basic discovery to clinical translation, @ISSCR_org's open-access society journal showcases research shaping the field. @stemcellreports.bsky.social is the Official Meeting Journal of #ISSCR2026. Learn more about the journal and meet the editorial team this July! invt.io/1bxb1ptim64

Stem Cell Reports, the ISSCR 2026 Official Meeting Journal.

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Connect, collaborate, and share ideas at the #ISSCR2026 Meet-Up Hub. Reserve a 45-minute slot to bring a group of scientists who share a common interest together and network with peers in your field. Space is limited - submissions are due 13 May. invt.io/1bxbxhbygc6 @isscr.org

ISSCR 2026 Meet-Up Hub submission ends 13 May

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Expand your professional circle at #ISSCR2026! Networking opportunities include small-group sessions in the Meet-Up Hub, networking breaks and receptions, & one-on-one partnering designed to facilitate collaboration & idea exchange. Register 👉 invt.io/1bxbwbe42g9 @ISSCR.org

Network with stem cell leaders at ISSCR 2026.

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Late-breaking abstract submission is now open for #ISSCR2026! Share timely results with the global stem cell community in Montréal this July through a poster presentation. Submit by 22 April 2026. invt.io/1bxbcu88q7l @isscr.org

ISSCR 2026 Late-Breaking Abstracts due 22 April

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#ISSCR2026 offers exclusive networking opportunities designed to connect you with researchers driving the future of stem cell science. Make connections that progress your research forward and join me at @ISSCR.org 2026 in Montréal, Canada this July. invt.io/1bxbpbz4ntg

Network with stem cell leaders at ISSCR 2026.

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Open doors to new collaborations, mentorship, and global recognition in the stem cell community by presenting your research at #ISSCR2026. Abstracts are due 25 February to be considered for oral presentations and travel & merit awards. invt.io/1bxbqnagnog @isscr.org

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The #ISSCR2026 scientific program brings together leading voices and new ideas, covering a wide range of topics from stem cell biology to organoids, disease modeling, and cell therapies. Submit an abstract by 25 February for the opportunity to present your research! invt.io/1bxbe647k59 @isscr.org

ISSCR 2026 abstract submission ends 25 February.

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Submit a science spotlight proposal to contribute to the scientific programming at #ISSCR2026! Organized by @ISSCR.org student & postdoc members, these sessions provide a fresh perspective on emerging scientific topics. Proposals are due 25 February invt.io/1bxb71pvmxv

Submit a Science Spotlight Proposal by 25 February.

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Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

biorxiv.org

Proud to co-lead this study with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin and rescues pathology, circuitry, and behavior. Preprint out now: @liganlab.bsky.social www.biorxiv.org/content/10.6...

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

biorxiv.org

The abstract submission deadline for #ISSCR2026 is coming up on 25 February! Submit your research to showcase your findings, connect with global experts, and gain visibility. Travel awards are available for early career researchers. Learn more: invt.io/1bxbxzw17hu @ISSCR.org

Submit an Abstract by 25 February.

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The #ISSCR2026 scientific program features the field’s most influential voices and groundbreaking science. Explore breakthroughs from basic biology to clinical translation and join the conversations driving stem cell research and regenerative medicine forward. invt.io/1bxbvudgat1 @isscr.org

Join me at the ISSCR 2026 Annual Meeting!

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Showcase your research on a global stage at #ISSCR2026! Submit an abstract by 25 February to share your latest stem cell discoveries, translational insights, or clinical advances. Research from all sectors is welcome - academia, industry, and beyond! invt.io/1bxbf5ww2b1 @ISSCR.org

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@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbvzmjckk

Join me at the ISSCR 2026 Annual Meeting!

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There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbscfory3 @ISSCR.org

Join me at the ISSCR 2026 Annual Meeting!

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Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxbah1l97q

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🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @sarahnaguib.bsky.social Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD Thank you PBL Assay Science for sponsoring the award

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Microglia replacement halts the progression of microgliopathy in mice and humans

Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

science.org

By me: A generation of scientific talent is at the brink of being lost to overseas competitors by the Trump administration’s dismantling of the National Science Foundation (NSF), with unprecedented political interference jeopardizing the future of US enterprise. www.theguardian.com/us-news/2025...

Scientists warn US will lose a generation of talent because of Trump cuts

Political interference and chaotic cuts to staff, programs and grants at the National Science Foundation are producing ‘devastating consequences’

theguardian.com

Could not be more proud and excited for @sadafamin.bsky.social as she begins her own lab at @washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊

Sadaf Amin@sadafamin.bsky.social · last yr.

I am thrilled to announce that I will be starting my lab at @washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

Gan Lab@liganlab.bsky.social · last yr.

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

sciencedirect.com

Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.

dlvr.it