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Schallek Lab

@schalleklab.bsky.social

At the junction of optics, neuroscience, ophthalmology and bioengineering. https://aria.cvs.rochester.edu/our_work/blood_flow.html

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Jan Lause@janlause.bsky.social · 2mo ago

We built a human-in-the-loop approach: the model proposes types, human experts refine and correct. As a proof of principle, we applied it to bipolar cells — and recovered all 15 known types. See those and more types in our gallery 👇 📸 eyewire.ai/gallery

15 images on a grid, each showing a single side views of different BC type examples. Cells sit between two nuclei layers (GCL and INL), and extend their axon terminals down. The differences between the types' stratification is clearly visible.Similar to the image before, but this time for 12 RGC type examples. Some types are asymmetric, others stratify broadly, others densely in the IPL.
Flaum Eye Institute@flaumeye.bsky.social · 2mo ago

June is marked as Vision Research Month. At Flaum, we are so grateful to all of our researchers and their work in researching the next generations of cures, treatments, and ways to improve vision for everyone.

Flaum Eye Institute researchers posing for a group photo on stairs. 10 people, four males and six females.
Schallek Lab@schalleklab.bsky.social · 2mo ago

📷-New Paper-📷 What does high blood sugar do to vessels of the eye?👁️ In human diabetic retinopathy, years of high glucose yield profound vascular changes. We find that in other species, this is not always true @cvsuor.bsky.social @urneuroscience.bsky.social dx.plos.org/10.1371/jour...

One year of hyperglycemia in the Ins2Akita mouse does not impart changes in retinal vascular patterning

Diabetic retinopathy (DR) is one of the leading causes of blindness often associated with retinal vascular pathology in humans. To aid our understanding of DR, the Ins2Akita mouse has served as a type...

dx.plos.org