Piotr Ziolkowski

@piotraz.bsky.social

Geneticist interested in (meiotic) recombination and impact of chromatin structure on DNA functions http://dgb.amu.edu.pl

⏳ Last days to register for the Plant Meiosis Meeting! Join us in Poznań for PMM 2026, with invited speakers Neil Hunter, Mathilde Grelon, André Marquez and Kyuha Choi. Raphaël Mercier, Chris Morgan, and many others also confirmed. 55 talk slots are waiting to be filled! Register: pmm.amu.edu.pl

Bild

📣We’re excited to announce that registration for the Plant Meiosis Meeting is now open‼️ The website and preliminary program are live, and abstract submission will open soon. Book accommodation early due to major trade fairs in Poznań! See you in Poznań! 🌱 pmm.amu.edu.pl

Bild

📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱 Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina! www.science.org/doi/10.1126/...

Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis

Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.

science.org

How do plants control the genes needed for successful sexual reproduction? Our new work uncovers the DREAM complex as a crucial regulator of meiotic recombination in Arabidopsis. Without DREAM, plants are sterile—key recombination genes like MER3 are switched off...

🌿🔍Paper alert‼️ A fantastic study from James Higgins’ group on SCEP3 – a newly identified component of the synaptonemal complex in plants! Happy that our team could be part of this! 😄🧬

Nature Plants@natplants.nature.com · 9mo ago

New OA Article: "SCEP3 initiates synapsis and implements crossover interference in Arabidopsis" rdcu.be/eQKqW A new synaptonemal complex protein; prevents clustering of crossovers during meiosis, so every pair of chromosomes receives at least one ‘obligate’ crossover.

🚨 New from our lab in #ScienceAdvances! RAD21L cohesin acts as both a 3D genome architect and a transcriptional gatekeeper in the male germline. Its loss disrupts both structure and function—highlighting the tight link between genome folding and gene regulation www.science.org/doi/10.1126/...

Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline

Deletion of the meiotic subunit RAD21L alters 3D chromatin structure and transcription in the mammalian male germ line.

science.org

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination. buff.ly/pZZfIso

The identification of the very conserved CTF18, SGO2 and SPF2 as suppressors of centromere-proximal crossovers highlights the importance of cohesin turnover in this process and opens up new possibilities for plant breeding. Much more in the paper : www.biorxiv.org/content/10.1...

Unlocking meiotic crossovers near plant centromeres

Crossovers (COs) ensure proper chromosome segregation during meiosis and generate genetic diversity. COs are non-uniformly distributed along chromosomes and almost universally suppressed in centromere...

biorxiv.org