Zinc-dependent turnover of ZIP3 transporter mRNA by trypanosome ZNK1 pubmed.ncbi.nlm.nih.gov/42728798/

Krasiļņikova assembled a T2T genome of Trypanosoma congolense, comparing it with T. brucei to reveal shared and divergent architecture, and provided preliminary evidence for differing strategies for antigenic variation via a common antigen 🔗 academic.oup.com/gbe/article/... #societyjournal #genome

De Novo Assembly of the Trypanosoma congolense Genome Reveals an Organization Influenced by Antigenic Variation but Distinct from Trypanosoma brucei

Abstract. Antigenic variation allows pathogens to evade mammalian adaptive immunity through the continuous change in exposed antigens. In African trypanoso

academic.oup.com

We really enjoyed writing this piece, which we hope will stimulate research in this area in T. brucei and other Kinetoplastids!

Trends in Parasitology@cp-trendsparasitol.bsky.social · 3w ago

More than just a phase: the essential role of condensates in Trypanosoma brucei survival

More than just a phase: the essential role of condensates in Trypanosoma brucei survival pubmed.ncbi.nlm.nih.gov/42674913/

A prelude to further cool insights about T. brucei cousin, Trypanosoma congolense!

kinetoplastids papers@kinetoplastpapers.bsky.social · 4w ago

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/42640060/

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/42640060/

Poly(A)-binding proteins in trypanosomatids and Plasmodium pubmed.ncbi.nlm.nih.gov/42615421/

Replicative slender bloodstream forms complete transmission of Trypanosoma brucei without prior differentiation into stumpy forms pubmed.ncbi.nlm.nih.gov/42616583/

The centromere localization domain of kinetoplastid kinetochore protein KKT2 recognizes the free N-terminus of histone H3 www.biorxiv.org/content/10.64898/2026.08.13.744621v1

Dynamic SUMOylation Controls RNA Polymerase I Extranucleolar Organization and Antigenic Variation in Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.08.14.744927v1

Identification of new protein-coding potential in Leishmania donovani using a proteogenomics approach pubmed.ncbi.nlm.nih.gov/42573611/

Genome-wide mapping of replication stress response factors reveals the management of polycistronic transcription, replication initiation, and responses to replication stress in Leishmania pubmed.ncbi.nlm.nih.gov/42573071/

An Auxin-Inducible Degron System for Trypanosomes pubmed.ncbi.nlm.nih.gov/42573698/

The major diagnostic VSG LiTat 1.3 of the human parasite Trypanosoma brucei gambiense is a trimer in solution pubmed.ncbi.nlm.nih.gov/42574507/

Leishmania guyanensis controls endogenous viral replication by a canonical RNA interference pathway www.biorxiv.org/content/10.64898/2026.08.09.743808v1

The underappreciated role of antigenic drift in Trypanosoma brucei immune evasion pubmed.ncbi.nlm.nih.gov/42567749/

Optimising Electroporation Protocols for Trypanosoma brucei Using the Amaxa 4D- Nucleofector System pubmed.ncbi.nlm.nih.gov/42567230/

Transcription Start Regions in PTU-intergenic regions drive cell cycle-dependent transcriptional activation events in Leishmania donovani pubmed.ncbi.nlm.nih.gov/42545030/

New preprint, revealing contrasting means of VSG expression in two African trypanosomes; great collaboration with @keithrmatthews.bsky.social Liam Morrison and other valued colleagues @janemunday.bsky.social @scotomorph.bsky.social @marquescata.bsky.social tinyurl.com/3n8b9pwv

Trypanosoma congolense Variant Surface Glycoprotein gene expression occurs in the absence of monoallelic transcription control

Antigenic variation is a very widespread process for pathogen evasion of mammalian adaptive immunity, involving the continuous change of exposed antigens. In many single-celled pathogens, antigen expr...

tinyurl.com

New work on T. brucei antigenic variation in cows and homologous recombination mutants, great collaboration with @keithrmatthews.bsky.social Liam Morrison and others. Big effort by Steve Larcombe @janemunday.bsky.social @goldrieve.bsky.social @scotomorph.bsky.social www.biorxiv.org/content/10.6...

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections

Trypanosoma brucei exploits an extreme form of antigenic variation to escape the mammalian immune response. This involves the progressive expression of antigenically distinct variant surface glycoprot...

biorxiv.org

Applying a proteogenomic approach for improving genome annotation in Leishmania panamensis using high-resolution mass spectrometry data pubmed.ncbi.nlm.nih.gov/42542199/

Trypanosoma congolense Variant Surface Glycoprotein gene expression occurs in the absence of monoallelic transcription control www.biorxiv.org/content/10.64898/2026.07.31.741978v1

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections www.biorxiv.org/content/10.64898/2026.07.31.741217v1

Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions pubmed.ncbi.nlm.nih.gov/42469243/

I got something I wanna talk about: parasite genomes! 🧬 Our lab at FMRP-USP is recruiting: 🔬 1 Direct PhD fellow 🧫 1 Postdoc fellow @agenciafapesp.bsky.social-funded to study how ubiquitination shapes genome replication & plasticity in Leishmania. Details in the comments👇

NuSAP1 promotes spindle assembly in Trypanosoma brucei by bundling spindle microtubules pubmed.ncbi.nlm.nih.gov/42401673/

Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite Leishmania www.biorxiv.org/content/10.64898/2026.07.01.735800v1

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites pubmed.ncbi.nlm.nih.gov/42376815/

H3K4me3 exhibits length-dependent deposition patterns at transcription initiation regions in Trypanosoma cruzi and correlates with transcriptional activity www.biorxiv.org/content/10.64898/2026.06.26.734760v1

First genome-wide centromere map of Trypanosoma cruzi suggests linear and 3D compartment boundaries and spatial clustering pubmed.ncbi.nlm.nih.gov/42304247/