Sean D. Stacey, Ph.D.
@seandstacey.bsky.social
Scientist, art lover, karaoke enthusiast, learning to cross stitch. Originally, East TennesSean. There will be typos and bad grammar. Posts are my own opinions. Go Bucks! He/him
Gorgeous paper and a plea for open data. ⬇️ See thread ⬇️
Ricardo D. Righetto@lifeonthewedge.bsky.social · 7mo agoThis one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]
The Distribution and Diversity of LuxI/LuxR Quorum Sensing Systems in Proteobacteria (Pseudomonadota) https://www.biorxiv.org/content/10.64898/2026.01.11.698852v1
How did @Nature become "prestigious" to scientists? In our opening article of Issue 09, writer Robert Reason traces the journal's history. By understanding how Nature’s prestige was constructed, we can also clarify which elements are deserved and which are entrenched.
#ScienceMonday 🧪 🦠 I've heard of picky eaters, but there's no reason to get your Type 6 Secretion System out over a meal,... but Vibrio will! Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota: Cell Host & Microbe www.cell.com/cell-host-mi...
Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota
Liu et al. show that dietary protein sources differentially restrict colonization of the pathogen Vibrio cholerae. Specific diets downregulate V. cholerae type VI secretion system (T6SS) expression, l...
cell.com
How to make phages work for you! A big hurdle is you. 🧪 🦠 mGem: Immune recognition and clearance of bacteriophages—implications for phage therapy | mBio journals.asm.org/doi/10.1128/...
mGem: Immune recognition and clearance of bacteriophages—implications for phage therapy | mBio
Bacteriophages (phages) are viruses that exclusively infect bacteria and cannot replicate within eukaryotic cells in the absence of their bacterial host. Discovered in 1915 (1, 2), more than 10 years ...
journals.asm.org
I've neglected my account but I'm graduating with an MBA in 16 days. I look forward to sharing more stuff, especially Microbiology in the new year! See ya'll soon! 🥳
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Mark O. Martin@markowenmartin.bsky.social · last yr.For #internationalwomensday, four #LuxArt portraits of famous microbiologists by @jennifer.j.quinn . From top left clockwise: Rita Colwell, Abigail Salyers, Rosalind Franklin, & Esther Lederberg. Maybe calendar next year: “Luminaries of Microbiology.” @ASMicrobiology @univpugetsound
Bacteria are always going to adapt to antimicrobials. Understanding how they are adapting is crucial to staying one step ahead. This article investigates how a strain of E. coli survived AMP exposure 🦠 🧪 www.jbc.org/article/S002...
Mutations in the essential outer membrane protein BamA contribute to Escherichia coli resistance to the antimicrobial peptide TAT-RasGAP317-326
Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics against antibiotic-resistant pathogens. TAT-RasGAP317-326 is an AMP with broad range antibacterial activity, but its m...
jbc.org
“There is biotechnological potential within this novel species that is yet to be explored.” Cool! 🥶 🦠 🧪 www.tandfonline.com/doi/full/10....
Penicillium psychrofluorescens sp. nov., a naturally autofluorescent Antarctic fungus
A new fungal species, Penicillium psychrofluorescens sp. nov. is described as a member of section Torulomyces. The new species is sister to P. catalonicum, and was isolated from soil collected from...
tandfonline.com
2025 is already racking up to have a bio-radical pathogenic bingo card. 🦠 www.cjonline.com/story/news/p...
Kansas tuberculosis outbreak is now America's largest in recorded history
Kansas public health officials say the state's ongoing tuberculosis outbreak is the largest since the CDC started reporting TB cases in the 1950s.
cjonline.com
I had a dream last night that I had 76k followers on here overnight. I’m not sure what even led to that. Must have been something impactful 😂
@who.int latest assessment release (December 20th) on H5N1 (Avian Influenza) 🦠 🧪 🫁 www.who.int/publications...
Updated joint FAO/WHO/WOAH public health assessment of recent influenza A(H5) virus events in animals and people
At the present time, based on available information, FAO-WHO-WOAH assess the global public health risk of influenza A(H5N1) viruses to be low, while the risk of infection for occupationally exposed pe...
who.int
@who.int article on undiagnosed #DiseaseX 🦠 🫁 🔬 Conflicting reports of death counts abound as multiple factors are affecting patient outcomes like malnourishment. www.who.int/emergencies/...
Undiagnosed disease – Democratic Republic of the Congo
Between 24 October and 5 December 2024, Panzi health zone in Kwango Province of Democratic Republic of the Congo recorded 406 cases of an undiagnosed disease with symptoms of fever, headache, cough, r...
who.int
🩻 🫁 Lung transplantation can be a huge upgrade for someone suffering from end-stage lung disease. However, infection and rejection are not the only things to be concerned about. How does pollution play a role in outcomes post lung transplant? jamanetwork.com/journals/jam...
Ambient Air Pollution Exposure and Outcomes in Patients Receiving Lung Transplant
This cohort study investigates the association of neighborhood fine particulate matter air pollution exposure with death or graft failure among lung transplant recipients.
jamanetwork.com
Lyme disease is endemic to several parts of the globe including North America. This article looks at vaccinating post infection of the causative agent. 🔬 🦠 journals.asm.org/doi/10.1128/...
A single immunization of Borreliella burgdorferi-infected mice with Vanguard crLyme elicits robust antibody responses to diverse strains and variants of outer surface protein C | Infection and Immunity
Borreliella burgdorferi, the primary causative agent of Lyme disease in North America (1, 2), is the most common tick-borne pathogen in the northern hemisphere (3, 4). The American College of Veterinary Internal Medicine recommends that dogs residing in, or near, endemic regions for Lyme disease be screened yearly for exposure to tick-borne pathogens (5). In 2023, the Companion Animal Parasite Council (CAPC) reported that 465,700 dogs in the United States tested positive for antibodies (Abs) to B. burgdorferi. The actual number of positive tests is much higher as only about 1/3 of test results are cataloged by CAPC. Antibiotic therapy generally results in positive clinical outcomes when canine Lyme disease is diagnosed and treated early (5). However, if untreated, transient intermittent lameness, polyarthritis, and potentially fatal nephritis may develop.
journals.asm.org
It’s Monday, so time to post some papers 😁 Hope you all have a great week 😉!
I started learning Gaeilge in October for my trip in March 🥳🇮🇪 Look what I learned on Duolingo in 2024! #Duolingo365
🫁 🩻 Here is the first single-cell study for patients with fibrotic hypersensitivity pneumonitis. The authors compare cell populations to idiopathic pulmonary fibrosis. Both diseases can lead to lung transplant so I’m double dipping in feeds. Happy reading! www.atsjournals.org/doi/full/10....
Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis | American Journal of Respiratory and Critical Care Medicine
Rationale: Fibrotic hypersensitivity pneumonitis (FHP) is a debilitating interstitial lung disease driven by incompletely understood immune mechanisms.
atsjournals.org
A difficult organism to study because…it…grows…so…slowly 😖 elucidating how it works can hopefully bring about treatments. 🔬 🦠 www.cell.com/cell-host-mi...
Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence
Accumulation of genetic variations including large-sized mutations in Mycobacterium tuberculosis’s genes associated with tuberculosis patient outcomes and bacterial antibiotic resistance ability.
cell.com
OK, this is just a damn cool article 🤯 🦠 🔬 Infecting the cell nucleus, gaining nutrients, but preventing cell death! www.nature.com/articles/s41...
An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host - Nature Microbiology
‘Candidatus Endonucleobacter’ is a pathogen of deep-sea mussels that can successfully reproduce in the nuclei of its host by expressing inhibitors of apoptosis, likely acquired through horizontal gene...
nature.com
