If you haven’t seen The Odyssey yet consider bringing ear plugs or AirPods. Liked the movie but ears are ringing and have a headache afterwards

Meet the amazing Mary Golda Ross. She was a trailblazing Cherokee/American mathematician and engineer, & Lockheed’s first female that designed secret missile programs. Brilliant & amazing! #Pinks #SheShed #ProudBlue #OneV1 airandspace.si.edu/stories/edit...

Mary Golda Ross: Aerospace Engineer, Educator, and Advocate

Engineer Mary Golda Ross made lasting contributions to the United States aerospace industry while opening doors for women and Native students to pursue S.T.E.M. education and careers.

airandspace.si.edu

I was trying to find an article for a family member with lung cancer that I knew I read in last few months in New England Journal on a clinical trial. (1) First went to NEJM website since I subscribe - no luck searching on lung cancer, failed EGFR, Chinese (site of study), 1/4

Can anyone figure out this spam. A real person called my husband’s cell twice saying he was getting calls from him. The person read out my husband’s cell even though he never called him. That happens. The strange part is that when the person called my husband it showed MY cell phone number twice!!

Happy to report that the results of germline testing as part of the National Cancer Institute/Children’s Oncology Group MATCH precision oncology trial was published. pubmed.ncbi.nlm.nih.gov/41166674/

Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial - PubMed

Coordinated germline and tumor panel testing was feasible and revealed P/LP CPG variants in 6.3% of the Pediatric MATCH cohort. Tumor variant fraction, germline association of CPG with tumor type, and adult-oriented guidelines were not predictive of germline status, emphasizing the need for systemat …

pubmed.ncbi.nlm.nih.gov

Welcome to #ASHG25! As our President Sarah Tishkoff just noted, next year for the first time the ASHG exec cmte will be all women. Glad to have anyone and everyone participating in this society now and in the future.

First Plenary Abstract Session of #ASHG25 starting with Srikar Gopinath from Yale describing their study characterizing >1M variants in the 5' UTR regions to assess their functional effects on gene translation and develop a prediction algorithm to evaluate non-coding UTR variation.

Congratulations to Andy Rivera @poseypod.bsky.social lab @bcmhouston.bsky.social grad student for putting together a standing room only session at #ASHG25

@nickywhiffin.bsky.social An article I thought you would appreciate. www.bozemandailychronicle.com/news/renu-sy...

‘We finally have a name’: At long last, Manhattan family gets an answer to daughter's rare genetic condition

As with so many calls previously about 9-year-old Delilah, Kelli Stanley braced for more uncertainty. But this time was different. This time, they finally had a name.

bozemandailychronicle.com

“The cause defended at Dayton is a continuing one that has existed throughout man’s brief history and will continue as long as man is here,” Scopes wrote in Center of the Storm, his 1967 memoir. “It is the cause of freedom, for which man must do what he can.”

Raw Story@rawstory.com · last yr.

Today I'm remembering what Lela Scopes told me about her famous brother for my Paducah Sun story going on 46 years ago.

Funny reversal of technology. I have received the print version of @nejm.org for >30 years. I get the hard copy at my house. I wanted to look at videos associated with article in June 26 issue I was reading today on Pompe disease. I can read the print version - but the digital issue is not online!!

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

In a modest bit of good news, NIH has released new NOFOs for all the NRSAs (and also Pioneer and New Innovator awards) grants.nih.gov/funding/nih-...

Durbin to Bhattacharya: "I can't understand it. I disagree w/ this admin on so many things. But this is the one that really gets to me personally. To think this nation would walk away from medical research. For God's sake...cancer, your budget requests a 38% cut to the National Cancer Institute"

That’s awesome! ….but, it’s also ~30 R01s The truth is that the US stood alone in large scale science funding— and reaped a lot of benefit for being -the- place where new things get discovered Realigning is going to be tough on everyone

The fallacy posed by the MAHAers is that if you eat healthy you are not going to be afflicted by diseases such as cancer. This is not just statistically stupid but it’s also cruel. Imagine telling the parent of a young child with cancer that you should have eaten more veggies. 1/

At the luncheon for our Baylor College of Medicine MD/PhD MSTP graduation reception. So proud of this group and what they have accomplished!! Heading off during challenging times!

📢📢Published today in @jem.org 📢📢 New human inborn error of immunity. We describe the first reported human with a monogenic disorder caused by the disruption of ZBTB7B, which encodes the transcription factor ThPOK. rupress.org/jem/article/... @ubcmedicine.bsky.social @bcchresearch.bsky.social

Stefan Pfister - KiTZ Heidelberg Genomics of pediatric tumors. What makes childhood brain tumors different (recent publication) and new data. Pediatric hallmarks of cancer. Don’t have environmental exposure but have hijacking of normal development (maturation block) and simple genomes. #MSKDevOnc

Richard Phillips - UPenn - epigenetic dysregulation of midline brain tumors. Different epigenetic regulator changes with age. Where K3.1 K27M is much younger than K3.3G34R/V tumors. IDH mutant is even older adults. Vulnerable periods of plasticity may differ. #MSKDevOnc #MSKkids

Piyush Joshi - German Cancer Research Center. Plasticity of Medulloblastoma Group 3/4. See overlapping molecular programs across subtypes. Single nucleus multi-omic experiments. Transcription factor network. #MSKDevOnc #MSKkids

David Teachey - CHOP on pediatric ALL treatment. Most of initial treatments developed in 1950’s. Hit a threshold with standard CTX in COG trials that ended in the 90’s, Focus on T-ALL - one good shot for initial treatment. Relapse not very successful. Need to improve frontline #MSKDevOnc #MSKkids

Jean Soulier - France Genomic Instability in MDS/Fanconi Anemia begins Day 2 of the Steel Symposium. Now up to 24 genes. See both MDS and AML with subsequent in adults get solid tumors H&N SCC. Aldehydes one cause of inter strand crosslinks. #MSKDevOnc #MSKkids

Paul Northcott - St. Jude - reviewing the history of the Medulloblastoma molecular anlaysis. 4 groups go back to many papers in 2006 to 2011. 2016 WHO classification separate out these diseases. Origins of MB for Group 3 & 4. #MSKDevOnc #MSKkids

Pallavi Mohapatra - Huangfu and Ziv labs. Pancreatic Neuroendocrine tumors. Highly heterogeneous depending on the type of Islet cells and the hormone expressed (10-40% of tumors). Remainder are non-expressing and diagnosed very extensive. Lack of targeted therapeutic options. #MSKDevOnc #MSKkids

Taryn Treger - UK - Wilms Tumor genetic predisposition. Compared WGS to 71 children with Wilms tumor with some known anomalies and similar number that were “negative”. Look at what is missed by standard analysis. #MSKDevOnc #MSKkids

Elena Vasileva - Amatruda Lab at Children’s Hospital LA. Working on molecular genetics of Ewing sarcoma. No previously available mouse genetic model. EWS-Fli is very toxic in mouse cells. Using Zebrafish as a mosaic model instead. Inducible model (Elife, 2022). #MSKDevOnc #MSKkids

Asher Steinberg - Kentsis lab Long read sequencing of sarcomas. Osteosarcoma high number of rearrangements but few point mutations. Doing long-read RNA sequencing to capture different isoforms by looking at splice junctions to get better patterns than short reads. #MSKDevOnc #MSKkids

Lauren Banks - MSKCC - breaking HLA restriction and using TCR to attack intracellular antigen. Desmoplastic small cell round cell tumor. EWSR1-WT1 defines this tumor type. Conserved exon sequence of fusion RNA. So have a specific and unique junction peptide fragment. #MSKDevOnc #MSKkids

Takeshi Fujino - MSKCC Pharmacology. Taking on Development of CAR-T cells targeting U5 snRNP200 for AML and b-lymphoid malignancies. Anti-U5 snRNP200 antibodies are being used. U5 snRNP200 is an RNA helicase part of the spliceosome. #MSKDevOnc #MSKkids