I love drafting detailed budgets and inclusion/enrollment reports for grants with a 6% funding rate!
Hunter Shain
@shainlab.bsky.social
UCSF, Department of Dermatology. Part of HTAN. Cancer, genomics, melanoma, cutaneous squamous cell carcinoma, dermatology, somatic mutations, tumor evolution, spatial transcriptomics, single-cell
The regulatory burden for awards with a less than 10% success rate is a pure waste. Initial submissions should just be aims and research strategy. Invite discussed applications to submit all the other stuff in a 2 week window after learning that they will be discussed.
I think this is actually good. Application length more than doubles with all these boilerplate letters
Oh, and Forms J are coming... grants.nih.gov/grants/guide...
Move over zebrafish. Welcome catfish. The newest model organism in the melanoma field. www.nature.com/articles/s41...
Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature
Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.
nature.com
I am being asked to review a lot of papers/grants on topics where I have not published yet, but I do have active research. My theory is that AI is recommending me to editors. If correct, it is creepy that it seems to know so much about our behind-the-scenes work
I was just asked to review. The mail came from a "no-reply@" address. The only way to decline was to create a 2-factor login, fill in a dozen required fields, and navigate through a user portal. If this was a predatory, no-name entity, I would ignore it, but this was a serious request
Major preprint from our group is out. Feedback welcome! We built the largest molecular atlas of cutaneous squamous cell carcinoma (cSCC) to date – linking somatic mutations and gene expression patterns to metastatic outcome. A thread 🧵 www.medrxiv.org/content/10.6...
Comprehensive molecular characterization of cutaneous squamous cell carcinoma reveals determinants of metastatic progression
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of cancer worldwide. While most cSCCs are not life-threatening, 2-5% of patients develop metastases. To better understand what c...
medrxiv.org
Lebron should just lean into the hoopla and do "The Decision 2.0"
I asked my echo to play classic rock, and it started playing Creed. I feel old!
Richard Scolyer, Cancer Expert Who ‘Became His Own Subject,’ Dies at 59 www.nytimes.com/2026/06/26/s...
Richard Scolyer, Cancer Expert Who ‘Became His Own Subject,’ Dies at 59
nytimes.com
At my institution, if you are a day late taking an online training module, there is no courtesy warning -- just an email straight to your boss (for me, Dept. Chair).
I heard the sad news on LI that Richard Scolyer passed away. He was a wonderful melanoma researcher and pathologist. He was a co-author on my first big paper in the field, describing the genomic landscape of desmoplastic melanoma. He was so kind and collaborative www.linkedin.com/posts/melano...
It is with a heavy heart that we share the deeply sad news that our cherished colleague Prof Richard Scolyer AO passed away yesterday 7th June 2026. Richard was a renowned pathologist and a world… | ...
It is with a heavy heart that we share the deeply sad news that our cherished colleague Prof Richard Scolyer AO passed away yesterday 7th June 2026. Richard was a renowned pathologist and a world aut...
linkedin.com
Visiting the National Cancer Institute with my colleague, Iwei Yeh, to learn about the cool science being carried out by the #HTAN project.
Apparently, my institution has a committee on committees, and they are seeking members. While I have a soft spot for service, I might pass on this one
☕ @shainlab.bsky.social , @bishaltandukar.bsky.social & co dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution. bit.ly/4wzMyX0
Somatic mutations distinguish melanocyte subpopulations in human skin - Nature Cell Biology
Tandukar et al. dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution.
bit.ly
Celebrating 4 oral presentations from our team at the Society of Investigative Dermatology Meeting in Chicago! Loes Hollestein @sharmaharsh.bsky.social Bárbara Rentroia Pacheco and myself with support from Arne Van Hoeck and Domenico Bellomo of SkylineDx BV. Look out for new prognostic tests in cSCC
STmut can now operate on Atera data from 10X Genomics. Here is a breast cancer that was profiled on the Atera platform
Excited to share our latest work from @shainlab.bsky.social lab, now out in Nature Cell Biology: “Somatic mutations distinguish melanocyte subpopulations in human skin.” We find evidence that melanocyte stem cell dynamics shape human skin homeostasis and UV response. www.nature.com/articles/s41...
nature.com
Excited to share that our paper, “Somatic mutations distinguish melanocyte subpopulations in human skin,” is now out in Nature Cell Biology. Reposting the thread below ⬇️
Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. www.biorxiv.org/content/10.1... [1]
For the fourth time in my ~12 year editorial career I was able to accept (in principle) a paper after one round of review. 🥳
@marinelab.bsky.social rocks it in the opening plenary of #AACR26, describing how to harness cellular plasticity to combat minimal residual disease. And I love the shoutout to STmut! Congrats Chris on all your success.
Why does Dillon Brooks have the Wikipedia logo tattooed on his arm
Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J
Tumour promotion through the lens of evolution
Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...
rdcu.be
When they are healthy, the Warriors are still a great team
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
rdcu.be
I am looking forward to attending #AACR26. I will be chairing an educational session describing work done by the Human Tumor Atlas Network (HTAN) on Friday at 3pm.
Erica Schwartz is expected to be selected by the Trump administration to lead the Centers for Disease Control and Prevention, pending approval from President Trump.
Trump Administration Eyes Erica Schwartz to Lead CDC
The health agency is facing leadership turmoil and controversy over vaccine guidance.
on.wsj.com