Nature research paper: A spatial atlas of the healthy human liver from live donors go.nature.com/4mwc6zV

A spatial atlas of the healthy human liver from live donors - Nature

A human spatial atlas of gene expression in liver based on live donors shows marked porto–central zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early steatosis.

go.nature.com

Happy to share our new preprint: Spatial Rewiring of Enterocyte Identity in Celiac Disease. We describe unexpected changes in enterocyte zonation in Celiac Disease.

Happy to share our new preprint: Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics: www.biorxiv.org/content/10.1... We utilize VisiumHD to extract intra-cellular mRNA polarization patterns in epithelial tissues.

New preprint 📜 from @AlanMonziani in the lab – EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology www.biorxiv.org/content/10.1... . A🧵

EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

Mammalian genomes are pervasively transcribed into long noncoding RNAs (lncRNAs), whose functions and modes of action remain poorly understood. EPB41L4A-AS1 is an evolutionary conserved, broadly and h...

biorxiv.org

Happy to share our new preprint: A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver: www.biorxiv.org/content/10.1...

What a cool new story by @shalevitzkovitz.bsky.social! They show which proteins and RNAs are expressed in the apical vs basal sides of intestinal epithelial cells (mice and humans). Some really interesting phenomenons @plosbiology.bsky.social @npariente.bsky.social journals.plos.org/plosbiology/...

Intracellular polarization of RNAs and proteins in the human small intestinal epithelium

The intestinal epithelium is a polarized monolayer of cells and both proteins and mRNAs have been shown to have global basal-apical polarization in mice. These authors perform a systematic analysis of...

journals.plos.org