Shai Bel (The Mucus Man)
@mucusman.bsky.social
The Bel Lab, boldly going where no one else bothers to. @erc.europa.eu funded lab. Opinions are my microbiota's. www.thebellab.com
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment science.org/doi/10.1126/... science.org/doi/10.1126/... @science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
science.org
I'm happy to share a perspective that @soniamodilevsky.bsky.social and I wrote about a new and exciting paper in @science.org with big implications for IBD. Check it out: A bacterial toxin disarms gut defenses against inflammation | Science www.science.org/doi/10.1126/...
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
Additional talks this fall include @mucusman.bsky.social, Selena Sagan (hosted by @uwmadisonmdtp.bsky.social), @teralevin.bsky.social, @csdetweiler.bsky.social, Jan Rehwinkel, Sung Chul Park, Claire O'Leary, Sean Crosson, @torreslab.bsky.social, and Patricia Champion
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…
sciencedirect.com
🚨While the world is burning down around us, I'm happy to share that I've been promoted to Associate Professor with tenure. Though this is considered a personal achievement, it was only possible due to the wonderful trainees in the lab, who carried me here❤️.
a man is writing prof on a blackboard
ALT: a man is writing prof on a blackboard
media.tenor.com
This was not our conference, please redirect to the appropriate advisory committee. beneficialmicrobes.events/advisory-com...
The 11th Beneficial Microbes Conference
The 11th Beneficial Microbes Conference will provide an overview of the latest scientific results and future developments related to pre- and probiotics and their importance to human and animal health...
beneficialmicrobes.events
This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b... Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
A coordinated cellular network regulates tolerance to food @nature.com @annarudnitsky.bsky.social @kedmiranit.bsky.social www.nature.com/articles/s41...
Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1
Excited to share the work of Mikayla Olson in the lab making a replication competent reporter virus for murine norovirus. journals.plos.org/plospathogen...
Development of a replication competent murine norovirus reporter system
Author summary Colloquially known as “the stomach bug,” human norovirus is a leading cause of foodborne illness worldwide. Despite its prevalence, there are no approved therapeutics or vaccines agains...
journals.plos.org
Our latest paper is now out. A long standing collaboration with the Sunyer lab where our teams show the requirement for secretory IgM in the gut mucosa to control microbiota homeostasis and metabolism. Enjoy! #sIgM #mucosalimmunology www.nature.com/articles/s41...
Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology
Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.
nature.com
Tomorrow I will host Will Ratcliff @wcratcliff.bsky.social in the virtual microbiology journal club. Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution" link below -
Secretory autophagy strikes again! 🧪 www.pnas.org/doi/10.1073/...
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex | PNAS
PARK7/DJ-1, a redox-sensitive protein implicated in neurodegeneration, cancer, and inflammation, exhibits increased secretion under stress. We prev...
pnas.org
🧪🔬🦠🧫🌍 This is the kind of paper we should all be waiting for! Because sadly we still don't have reliable methods to count bacterial abundance from microbiomes. (I haven't read it yet, but I love the intention already) www.nature.com/articles/s41...
Absolute quantification of prokaryotes in the microbiome by 16S rRNA qPCR or ddPCR - Nature Protocols
This protocol enables rigorous and reproducible quantification of prokaryotic concentration in stool samples by 16S rRNA qPCR or ddPCR.
nature.com
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
kwnsfk27.r.eu-west-1.awstrack.me
Had an amazing time at #APS2025, and so happy to have presented my poster and flash talk! First conference ✅
Edelblum Lab@edelblumlab.bsky.social · last yr.And that’s a wrap on #APS2025! Thanks to all our amazing @apsphysiology.bsky.social GI & Liver Section leaders + members for a fantastic meeting. One last shoutout to @ananya-p.bsky.social for excellent presentations all around 🤩 #proudPI #GIresearch @sinaiimmuno.bsky.social
✨🦟✨HOW DO MOSQUITOES HAVE SEX? ✨🦟✨ Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES! www.biorxiv.org/content/10.1...
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
a purple octopus with big eyes is crawling on the ground in the ocean .
ALT: a purple octopus with big eyes is crawling on the ground in the ocean .
media.tenor.com
Honored to have been invited to give a #GlobalImmunoTalk! Grateful for the opportunity to share our work with the global immunology community. If you missed it, you can watch the full talk here 👇🏼 www.youtube.com/live/jBLDd3M...
"The Architecture of Intestinal Inflammation and Healing" by Dr. Eduardo Villablanca
YouTube video by GLOBAL IMMUNOTALKS
youtube.com
Very excited to share the first study from the lab!!! We found a pro-tumor niche dictated by neutrophil-cancer cell physical crosstalk in the breast #TME Published in Nature Cancer Kudos to @sandracamargog.bsky.social and @orimoskowitz.bsky.social for leading it
@meravcohenlab.bsky.social · last yr.We are beyond excited to share the first publication of our lab! We highlight the role of #neutrophils in shaping a more aggressive #TME through physical interactions with #breastcancer cells. The work was led by the talented @sandracamargog.bsky.social & @orimoskowitz.bsky.social 🧵
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators. www.sciencedirect.com/science/arti...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
sciencedirect.com
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Shai Bel (The Mucus Man)@mucusman.bsky.social · last yr.🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
Super excited to host Shai in Madison starting this fall!! bsky.app/profile/mucu...
Shai Bel (The Mucus Man)@mucusman.bsky.social · last yr.🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
