Excited and grateful to be chosen as the 2026 ASCB Innovation in Research Award recipient! I especially want to thank all lab members, whose research is recognized here. Congrats as well to the other ASCB honorees.

American Society for Cell Biology@ascbiology.bsky.social · 2d ago

Congratulations to the 2026 ASCB Honorific Award Winners! ASCB is proud to recognize scientists whose research, mentorship, education & leadership are helping shape the future of cell biology. See all the awardees: https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/

If you have an NIH or NSF program officer, post a comment!

I-270, Exit 1@i270exit1.bsky.social · 3d ago

🚨🚨 FEDS and everyone else 🚨🚨 🧵Tomorrow is the last day to comment on the Office of Personnel Management rule, “Promoting Employee Accountability" at www.regulations.gov/commenton/OP... This rule eliminates employee protections and rights, and hastens the firing process. Specifically, it... 1/4

Carolyn Ott @hhmijanelia.bsky.social, Jennifer Lippincott-Schwartz & David Breslow @davidbreslowlab.bsky.social explain how recent advances have expanded our models of primary cilia disassemble and discuss emerging roles of altered disassembly in disease. journals.biologists.com/jcs/article/...

📣 Abstract submission and early registration are now OPEN for the 7th European Cilia Conference—an official EMBO workshop! 📅 8–12 March 2027 📍 Stresa, Italy Submit and register: meetings.embo.org/event/27-cilia www.eurocilia.eu #EMBOCilia #Cilia2027

Also in Issue 13: - Research Highlights on a fungal virulence factor, ER-Golgi contact sites, ammonium transporters and neuron-epidermal attachment. - Opinion on the response to lysosomal damage - Primary cilium disassembly Review journals.biologists.com/jcs/issue/13...

Excited to share our review article on cilia disassembly, published in @jcellsci.bsky.social. journals.biologists.com/jcs/article/.... We highlight how disassembly of cilia occurs, ...

Primary cilium disassembly – from mechanisms to roles in physiology and disease

Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.

journals.biologists.com

Please come join me in Washington, DC August 2-6th for the FASEB SRC on Cilia and Centrosomes meeting! Over 40 talks will be selected from abstracts. We are also excited to launch our first North American Ciliopathy Summit, held at the same venue on August 2. events.faseb.org/event/cilia-...

We are recruiting a post-bac researcher to join our lab in Yale MCDB! Ideal for a recent college grad looking to get in-depth research experience and mentoring in genetics & cell/molecular biology, working on exciting cilia-related projects. Details: breslowlab.yale.edu/news/post-gr...

Imaging-based CRISPR genome screening allows effects of cell-regulating molecules & modifications to be revealed in live & fixed cells – applied here to frog embryo cilia 📹 Jingbo Sun et al @davidbreslowlab.bsky.social @yale.edu in @cp-devcell.bsky.social ➡️ bpod.org.uk/archive/2026...

Ever wanted to do a genome-scale CRISPR screen for a microscopy phenotype? Pooled CRISPR screens are amazing, but hard to combine with imaging... Excited to share our latest work in Dev Cell on a technology platform for imaging screens and applications to primary cilia: www.cell.com/developmenta...

A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

Sun et al. develop a microscopy-based CRISPR screening platform that combines ease of implementation with flexible analysis of live-cell or antibody-based markers. Screens in human cells using a serie...

cell.com

Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase. www.nature.com/articles/s41...

An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications

Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...

nature.com

We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨ With @jiyeonleem.bsky.social and our team at Yale MCDB. Read: www.nature.com/articles/s43...

A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging

To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...

nature.com

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia

A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.

science.org

I'm thrilled to share our new preprint, in which we've found that neurotransmitters can be chemically "marked" as a way to incorporate metabolic history - such as diet or life stage. www.biorxiv.org/content/10.1... Led by Porhathai "Un" Malaiwong, Allen Schroeder and Tia Brown. (1/6) 🧵

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state

Animals must flexibly respond to environmental stimuli to survive, and optimal responses critically depend on the organism's current needs. Many organisms have evolved both cell-intrinsic and intertis...

biorxiv.org

Calling all biologists! 📢 Is your research at the cutting edge of synthetic biology, genomics or AI? Apply to join our team of world-class scholars!🔬🦠 Tenure-track Assistant Professor Anticipated Start Date: July 1, 2026 #hiring #genomics #biology apply.interfolio.com/172428

Very few PhD students finish within 4 years. But international students will need to do that if US proposed visa rules change go through. Sound reasonable to you? Fed register is accepting comments for next month. Details at the link & comment button www.federalregister.gov/documents/20...

Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media

Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

federalregister.gov

“The Senate Committee on Appropriations is scheduled to release its proposal for NIH’s 2026 budget later this week…The committee could include language that would prohibit the multiyear funding plan or extend the timeline for the transition.”🧪

Jeremy Berg@jeremymberg.bsky.social · last yr.

New Science story about multi-year funding and it potential catastrophic consequences www.science.org/content/arti... 1/n

Want to publish a NIH-funded paper in Nature? Well - unless your institution has an agreement with Springer, you'll have to be mega-rich to be compliant with NIH's new no-embargo policy. Springer is insisting on gold OA - that's $12,690 and that's extortion.

Katherine Brown@katherine-brown.bsky.social · last yr.

This is a useful summary of how some major publishers are responding to the new NIH policy. We've just updated our policies at @biologists.bsky.social: @dev-journal.bsky.social @jcellsci.bsky.social and @jexpbiol.bsky.social will allow authors to deposit the accepted version with zero embargo.

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

the word alert is in a purple circle

ALT: the word alert is in a purple circle

media.tenor.com

We're live! @inikon.bsky.social used modular proximity labeling to identify ciliary EV cargo in #celegans. This EV-TurboID approach can be applied in cell- & tissue-specific manners to define the composition of distinct EV subtypes, a major challenge of the EV field. www.nature.com/articles/s41...

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans - Nature Communications

Decoding the content of extracellular vesicles (EVs) is key to understanding cell communication. Nikonorova et al. used targeted proximity labeling to uncover polycystin EV cargo and cargo-loading mec...

nature.com

Maureen Barr@barrlab.bsky.social · last yr.

Just got proofs, including 90 pg critique/response for 7 reviewers: "One suggestion of how the manuscript could increase its impact would be e.g. by validating their findings in relevant human cell lines" 😭 Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

Trump promised scientific breakthroughs. Researchers say he’s breaking science.

NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

wapo.st

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms

The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this ...

science.org

Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!

Cell Chemical Biology@cp-cellchembiol.bsky.social · last yr.

Online now! An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology by Anna B. Seminara and Stavroula K. Hatzios @hatzioslab.bsky.social‬ at @yale.edu @mcdb-yale.bsky.social http://dlvr.it/TJRWKG

CT folks! Let’s come together and make signs for #standupforscience! @luskinglab.bsky.social

Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...

A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.

Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...

biorxiv.org

Trump's illegal NIH cuts mean cancer researchers would be laid off, sick kids going without treatment, and more. These cuts would be DEVASTATING for lifesaving research. Some Republicans have said they agree—but they just blocked my amendment to reverse Trump's NIH cuts anyway.

Trump Administration Stalls Scientific Research Despite Court Ruling. Story by Ben Mueller. Gift link: nyti.ms/435szDm

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)

Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

nyti.ms

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. https://go.nature.com/4gM6oW4

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

go.nature.com

So can anyone shed light on how long they can legally keep the NIH communications freeze in place? It's been a long time since February 1 came and went. Is there any legal recourse?

A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter. By @avaskham.bsky.social bit.ly/3X8ngz8

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

thetransmitter.org