Simon Bayly
@simonbayly.bsky.social
Reformed chemist 👨🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.
Flash in the pan www.reuters.com/world/no-dis... #biotech
EXCLUSIVE: 'No discussions' over AstraZeneca-Bristol Myers deal, senior source says
There are "no discussions" ongoing between AstraZeneca and Bristol Myers Squibb over a potential deal, a senior source close to the matter told Reuters on Wednesday, quashing the prospect of a moote...
reuters.com
"We are doing a pretty good job at manufacturing keys, but they are generally for the wrong locks" From the founder and CEO of In Sitro #biotech deepphenotype.substack.com/p/drug-disco...
Drug Discovery Has No Magic Wands
On AI, human biology, and what it will actually take to discover transformative new medicines
deepphenotype.substack.com
Whole-body spatiotranscriptomics in mice reveals 379 cell types across 59M single cells, advancing tools for biomedical research and enhancing machine learning applications. 🤖✨ PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4
No description available
cell.com
“I didn’t think we could cure this condition, but I now do.” In a profile interview, Veronica Kinsler reflects on one amazing evening of scientific discovery that opened up the possibility of a cure for congenital melanocytic naevi (CMN). Watch the full interview: youtu.be/Gqtm6G587SQ
Acrobat has offered to turn a PDF of an airport parking ticket into a podcast. Can’t imagine it would be a great listen.
Greater Manchester Mayoral By-Election Result: 🌹 Craig | LAB: 47.2% ➡️ Astley | RFM: 21.0% 🌍 Coggins | GRN: 12.2% ◼️ West | RES: 8.7% 🌳 Eckersley | CON: 7.7% 🔶 Kilpatrick | LDM: 2.2% 🙋 Farmer | Ind: 0.6% 2nd Round: 🌹 Craig | LAB: 66.3% ➡️ Astley | RFM: 33.7% Labour HOLD.
New @talusbio.bsky.social #AI preprint just dropped 🚀 Meet Ptarmigan-1. It predicts which small molecules bind a protein, and which residues they hit, from sequence and 2D chemistry alone. No structures, no docking, no poses. www.biorxiv.org/content/10.6... Time for a 🧵 (1/13)
Structure-free, site-resolved contrastive learning extends small-molecule discovery beyond the reach of structure-based modeling
Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target. Most modern methods answer by building and scoring ...
biorxiv.org
Cool method for nano pore based peptide sequencing, nice use of copper-free click chemistry as well! www.nature.com/articles/s41...
Sequential reading of a stepwise-shortened peptide immobilized on nanopore - Nature
A nanopore-based ‘chop and measure’ method sequences peptides at single-amino-acid resolution by using enzymatic digestion to progressively shorten the N terminus one residue at a time,...
nature.com
Also contains the titbit that Deepmind is disbanding the Alphafold team and going all in on LLMs to ‘automate science’
Ken Tindell@kentindell.bsky.social · last wk.“AI or die” @robarmstrong.bsky.social’s explanation for why Meta et al are crazy all in on AI even if it means death: the alternative is obsolescence. Maybe this is all Kodak redux.
Not sure what you call this investment strategy! www.linkedin.com/posts/thatmr...
YOU CAN GET $10K IF YOU READ + SHARE THIS POST. I'm giving away $10k in an uncapped SAFE to early stage biotech teams. Simple 5-minute application below. Interviews + acceptance in 2 weeks. If…...
YOU CAN GET $10K IF YOU READ + SHARE THIS POST. I'm giving away $10k in an uncapped SAFE to early stage biotech teams. Simple 5-minute application below. Interviews + acceptance in 2 weeks. If sele...
linkedin.com
But Godzilla is titled for the monster while Odysseus isn't the monst... wait a minute🤔
"Functional information-processing taking place in an atemporal mathematical space is so utterly unlike the lived intelligence of a human being that to call it “intelligence” at all is to wholly falsify its nature." giftarticle.ft.com/giftarticle/...
Why this philosopher turned down Anthropic
The AI industry is courting the humanities — but it is asking the wrong questions
giftarticle.ft.com
I got a job in clinical research, but they made me study design.
Simon Bayly@simonbayly.bsky.social · 2w agoI got a job as a patent attorney, but it put too many claims on my time.
I got a job in clinical research, but they made me study design.
Simon Bayly@simonbayly.bsky.social · 2w agoI got a job as a patent attorney, but it put too many claims on my time.
I got a job as a patent attorney, but it put too many claims on my time.
Richard K@rkemb.eurosky.social · 2w agoI got a job doing nuclear fusion; it's very hot right now.
I got a job making recombinant proteins, but they didn't like my expression.
Richard K@rkemb.eurosky.social · 2w agoI got a job making trifle but it never really gelled.
Pogi annihilates the Alpe d’Huez record 💥 Tadej Pogačar made the fastest-ever ascent of Alpe d’Huez on the way to winning Stage 19 of the Tour de France, breaking the previous record from 1995 by 1:14 with a time of 35:26.
"Colossal Biosciences reportedly in talks to raise new capital at $20B–$30B valuation"
Ryan Reynolds: Huh Confused
ALT: Ryan Reynolds: Huh Confused
static.klipy.com
It takes some elegant antibody engineering to try to achieve a meaningful therapeutic window for IL-2 receptor agonist antibodies www.nature.com/articles/s41...
Engineering trispecific IL-2 receptor agonistic antibodies through geometry optimization for enhanced Treg targeting - Nature Communications
Regulatory T cells (Treg) play critical roles in immunological tolerance and their requirement for IL-2 poses a potential therapeutic avenue. Here, the authors engineer and optimize a trispecific IL-2...
nature.com
look at that thing! 👇👇👇👇
Ján Bíňovský@jbinovsky.bsky.social · last mo.🔥My first (co)first-author paper is out🔥 The surfaces of Gram+ and Gram- bacteria are markedly different from each other. How are phages equipped to breach the Gram+ envelope❓ 💡We report a baseplate structure uniquely adapted to infect Gram+ S. aureus. A 🧵⬇️ 1/8 #phagesky #cryoEM 🧪
Removing smoke does not put out the fire
Thiago Carvalho@cyrilpedia.bsky.social · 2w ago'I think it should go without saying that if removing amyloid deposits from the brain really helped Alzheimer’s patients that you would expect much more benefit than this, because there seems little doubt that these antibodies do accomplish that.' @dereklowe.bsky.social
Pillar/Encode has published a list of 124 challenges for AI in science. Do any of them resonate? encode-challengescape.pillar.vc
Encode: Challengescape
Encode: AI for Science - Challengescape
encode-challengescape.pillar.vc
