Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Nikolai Slavov@slavov-n.bsky.social · 2y ago

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

The past 15 months have marked a dark chapter in US science; one that will require significant effort to repair. But I'm not interested in duct tape and bandaid solutions. Our system had problems before Jan 20th, 2025. So, @standupforscience.net is doing what we do best: TAKING ACTION. 1/7

An example of the perils of presidential control over science agencies. This Budget Request is dictated by the White House, Vought, and the P2025 OMB, not NSF. We have an imperial presidency, the dream of John Roberts and Charles Koch since the 80s. And it is incompatible with successful science.

Leslie Rissler@ljrissler.bsky.social · 4mo ago

I am shocked to see this language from the NSF. “The U.S. National Science Foundation's Fiscal Year 2027 Budget Request reflects a strategic alignment of resources in a constrained fiscal environment while eliminating woke and weaponized grant programs that previously funded radical DEI projects.”

#HepatitisB virus newborn vaccination rates in the US peaked at 83% in early 2023 but dropped to 73% by August 2025, coinciding with increased public discourse regarding childhood vaccination. ja.ma/47rCO6p

The last part abt how measles disrupts immunity vs other infections is, imo, underappreciated (& mechanism was recently clarified). It's part of why measles vaccination was seen to help beyond just reducing measles complications - not getting measles reduces severity of subsequent infections too.

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

Measles virus infection can cause long-term damage to the immune system.

science.org

Ryan Marino, MD@ryanmarino.bsky.social · 5mo ago

Before the vaccine, 10% of measles infections resulted in deafness. Measles currently causes 100K children/yr to become blind. Even those who recover completely can later develop the fatal encephalitis. Every infection disrupts the immune system and can cause loss of all immunity to other infections

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

nature.com

The incidence and prevalence of #melanoma, the fifth most common cancer in the US, have increased over the last 5 decades. This Review summarizes the epidemiology, pathophysiology, diagnosis, and treatment of cutaneous melanoma. ja.ma/4j1AhEC

We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—

bioRxiv Bioengineering@biorxiv-bioeng.bsky.social · 8mo ago

Sequence and structural determinants of efficacious de novo chimeric antigen receptors https://www.biorxiv.org/content/10.64898/2025.12.12.694033v1

This is shocking stuff. John Quackenbush has been brilliant since forever. www.statnews.com/2025/12/05/r...

His lab was humming with discovery. After one year under Trump, it’s almost silent

John Quackenbush built a lab that is at the forefront of human genetics research and bioinformatics. Trump administration cuts have put it in danger of collapse.

statnews.com

You run a new command in #rlang #python #bash, and you don’t really know how long it should take. Will it be done in 30 seconds? 5 minutes? 45 minutes? Longer? 😫 An automatic notification might help to stay focused on #programming Let me introduce you to ntfy.sh slowkow.com/notes/ntfy/

Get notifications on desktop and mobile from long-running jobs in your terminal sessions

If you’re like me, you get tired of waiting for long-running jobs in the terminal. You run a new command, and you don’t really know how long it should take to finish. Will it be done in 30 seconds? 5 ...

slowkow.com

Cruz Godar shares stunning Javascript and webGL applets that demonstrate the beauty of mathematics. cruzgodar.com

A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions. A bit of a video explainer here: 1/ 🧪

Check out our new paper @nejm.org. RSV, COVID-19 & Influenza vaccines continue to show consistent effectiveness & safety based on a review & synthesis of 500+ research studies👇! We worked hard to evaluate the evidence so you can be confident about getting vaccinated this fall!

Madhu Pai, MD, PhD@madhupai.bsky.social · 9mo ago

Even as the anti-vax lobby erodes public trust, new evidence confirms that "immunizations against Covid-19, RSV, and influenza have shown consistent effectiveness & safety and are associated with a substantially reduced risk of hospitalization & severe disease" www.nejm.org/doi/full/10....

South Carolina schools recently sent home unvaccinated kids to stem a growing measles outbreak. It turned out 5 of them were infected and, if they'd been at school, could've unwittingly spread it to their classmates for days. That kind of precaution is now illegal in Idaho.

Idaho Banned Vaccine Mandates. Activists Want to Make It a Model for the Country.

The Idaho Medical Freedom Act makes it illegal to require anyone to take a vaccine or receive “medical intervention.” Leslie Manookian, the activist behind the law, hopes to make it a “societal norm” ...

propublica.org

New release of PowerLMM.js! Browser-based power analysis for longitudinal models with dropout. Now includes: - Power analysis summary report - Reproducible & shareable configs (URL/JSON) - Calculations validated against R - Hypothesis region visualization powerlmmjs.rpsychologist.com

Long Covid Is Real — And It’s Changing an Entire Generation Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e Feature: www.rollingstone.com/culture/cult...

A visualization of average resting heart rate in Germany from 2020 through 2022. Link: corona-datenspende.github.io/en/vitaldata... Data: zenodo.org/records/8229...

I'd like to announce the medRxiv preprint of our latest work: A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity. www.medrxiv.org/content/10.1...

Search #Pubmed and view the results on a 2D embedding. Each point represents a paper, and similar papers are near each other. Colors indicate clusters of similar papers. By Viktor Petukhov github.com/multicore-ca...

AI slop and the destruction of knowledge irisvanrooijcogsci.com/2025/08/12/a...

AI slop and the destruction of knowledge

This week I was looking for info on what cognitive scientists mean when they speak of ‘domain-general’ cognition. I was curious, because the nuances are relevant for something I am researching at t…

irisvanrooijcogsci.com

1. Make an Excel file with your author information 2. Drag and drop 3. Copy a nicely formatted author list into Word 🐶 slowkow.com/authorbud

Convert Markdown to C++, Python, MATLAB, and LaTeX iheartla.github.io by Yong Li

☀️THE SUMMER FIGHT FOR SCIENCE☀️ 🫵 WHO: You + all our friends 🧪 WHAT: Share science with your neighbors and tell them about the impact of proposed budget cuts. 🇺🇸 WHERE: Your local community 🏖️ WHEN: Now to Sept 30th 🔬 WHY: The 9/30 budget vote will determine the future of science in America.

5 pages of this in the HHS Terminated Grants document Link: taggs.hhs.gov/Content/Data...

The destruction of the medical research enterprise in the U.S. will go down in history as one of the most damaging choices a government has made in setting its population backwards www.nytimes.com/interactive/...

Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)

Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

nytimes.com

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Illegal arrests made by the Trump administration are intended to spread fear and silence dissent. We cannot allow Trump and his cronies to turn the United States of America into an authoritarian society in which people can be disappeared for their political beliefs.

My colleagues and I demand answers from Kristi Noem and Marco Rubio about the illegal and inhumane abduction of Mohsen Mahdawi, a permanent legal resident of the United States. The Constitution guarantees people within our borders basic rights, including due process and free speech.

Kilmar Abrego Garcia must be released and brought home to Maryland. He is innocent. No government can snatch people off the street and ship them to prison without due process. It should terrify us all. I'm thankful @vanhollen.senate.gov is headed there to demand his release.

Senator Chris Van Hollen@vanhollen.senate.gov · last yr.

I just landed in San Salvador a little while ago, and I look forward to meeting with the team at the U.S. embassy to discuss the release of Mr. Abrego Garcia. I also hope to meet with Salvadoran officials and with Kilmar himself. He was illegally abducted and needs to come home.