Excited to share our story on diadenylate cyclases in bacterial immunity! Building on the discovery of Panoptes, we present Panoptoo: a DAC operon that uses cUA to guard against phage infection. Grateful to @daniellehaley.bsky.social and @kranzuschlab.bsky.social www.biorxiv.org/content/10.6...

Bacterial diadenylate cyclase domains synthesize diverse nucleotide signals in anti-phage defense

Bacterial diadenylate cyclase (DAC) enzymes synthesize the nucleotide signal 3′3′ cyclic di-AMP (3′3′-c-di-AMP) to control osmoregulation, cell-wall homeostasis, and DNA-damage responses. Here we disc...

biorxiv.org

The shared principles of human and bacterial antiviral immunity An honor to highlight remarkable discoveries from many labs over the past 12 years that unite previously disparate fields of how animal cells and prokaryotes defend against viruses. www.nature.com/articles/s41... rdcu.be/fzwyB

Shared principles of human and bacterial antiviral immunity - Nature

The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector...

nature.com

Professor in Bacteriophage Biology & Evolution at the University of British Columbia (UBC). Closing date 1 October, with an expected start date no earlier than January 1, 2027, and a salary within the range of $200,000 to $270,000 per year. For details: ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

Today we are excited to introduce you to PanDA 🐼🐼🐼, a newly uncovered antiphage system!! Attendees at @SISB2026 would have heard a little about this from graduate student Ali Nabhani back in May, but we are now out here in preprint form and delighted to share more of the details. (Thread below)

Minimal diadenylate cyclases have been co-opted to detect phage immune evasion

Many bacterial immune defenses transmit recognition of phage infection via the generation of diverse cyclic nucleotide second messengers. Phage have evolved to subvert this kind of immunity by sequest...

biorxiv.org

Minimal diadenylate cyclases have been co-opted to detect phage immune evasion https://www.biorxiv.org/content/10.64898/2026.08.10.743972v1

Do you need to analyze bacterial microscopy data and are looking for an all-in-one tool for Windows or macOS? Check out BactoMate by Lasse Hallenga and Philipp Popp! I'm happy that we were able to contribute to this great work. www.biorxiv.org/content/10.6...

BactoMate: an integrated platform for reproducible bacterial microscopy analysis

Quantitative microscopy of microorganisms increasingly produces large, multidimensional datasets, yet their analysis often depends on fragmented workflows spanning file conversion, segmentation, quali...

biorxiv.org

Pls share: Three open posions in Bacteriology at Wisconsin: bact.wisc.edu/bacteriology...

Bacteriology is Hiring!

Bioeconomy Assistant Professor The Department of Bacteriology is seeking applicants at the Assistant Professor level to launch a research program in the New Bioeconomy. Applicants may be interested in...

bact.wisc.edu

Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9zv3rj...

DNA glycosylases are repair enzymes, essential to all cellular life. They find chemically damaged bases and remove them so DNA can be repaired. Today in Nature Microbiology, we show bacteria have repeatedly repurposed them into antiviral immune systems 🧵 www.nature.com/articles/s41...

Antiviral defence is a conserved function of diverse bacterial DNA glycosylases - Nature Microbiology

DNA glycosylases, typically used for DNA repair, can also protect bacteria against phages that would otherwise evade host immunity by incorporating modified bases into their genomes.

nature.com

Beautifully done and important trial. An effective mTb test that utilizes tongue swab specimens will be absolutely transformative for Tb diagnosis especially is resource limited settings. Definitely practice modifying. www.nejm.org/doi/full/10....

Pulmonary Tuberculosis Detection with MiniDock MTB Using Swab Samples | NEJM

Improved diagnostic tools for tuberculosis that are suitable for use in peripheral health centers are essential for reducing the persistent gap between estimated and notified cases. The diagnostic ...

nejm.org

Excited to share our lab's first paper on the evolution of a c-di-GMP-controlled sigma factor: journals.asm.org/doi/10.1128/...

Regulatory divergence and functional diversification of a c-di-GMP-controlled sigma factor in Actinomycetota | mSystems

Mounting global responses to dynamic environmental conditions is a crucial function that bacterial cells must perform. Global regulatory networks are most often studied in individual species, however,...

journals.asm.org

Nominations for the 2027 New Voices in Infection and Immunity cohort are now open: asm.org/NewVoices-IA...

Antiviral defence is a conserved function of diverse bacterial DNA glycosylases | Nature Microbiology

Antiviral defence is a conserved function of diverse bacterial DNA glycosylases - Nature Microbiology

DNA glycosylases, typically used for DNA repair, can also protect bacteria against phages that would otherwise evade host immunity by incorporating modified bases into their genomes.

nature.com

One of our most popular preprints of 2025 is now published in @science.org. Congrats to @brianhie.bsky.social, @samuelhking.bsky.social, and team on establishing a framework for generating and evaluating AI-generated genomes. - Access the paper: www.science.org/doi/10.1126/...

Generative design of bacteriophages with genome language models

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

science.org

Arc Institute@arcinstitute.org · 11mo ago

In a new preprint from @brianhie.bsky.social's lab, the team reports the first generative design of viable bacteriophage genomes. Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.

The 2027 Chemistry Faculty Jobs List has 53 tenure-track positions and 2 teaching-only positions: docs.google.com/spreadsheets... #facultychemjobs #chemsky #chemchat ⚗️🧪

The 2027 Chemistry Faculty Jobs List

docs.google.com

Save the date! The 23rd International Conference on Bacilli and Gram-Positive Bacteria will take place from June 29 to July 2 in Ljubljana, Slovenia! #pogacar #pogi #subtiwiki

I'm excited to be co-organizing the 2026 Midwest Microbial Pathogenesis Conference, which will take place Sept 25-27 on the UMN campus in Minneapolis! Poster abstracts due Aug 7! Submit yours & register here ➡️ mmpc2026.umn.edu

Out now! In collaboration with Hiroshi Nishimasu's lab, we uncover how a dual reverse transcriptase immune system builds double-stranded DNA from both RNA and protein templates. www.cell.com/cell/abstrac... Previous thread for the preprint: bsky.app/profile/ster...

Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system

Bacterial reverse transcriptases defend against viruses, yet how their DNA products stop infection remains unknown. Bacteriophage inhibition of a host recombination enzyme activates the DRT3 defense s...

cell.com

I can finally get this video posted on bluesky. This cartoon illustration should be more clear describing the newly developped transient Pore Analyte Looping (tPAL) platform and the "chop and measure" mode for nanopore protein sequencing. @nature.com www.nature.com/articles/s41...

Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

A c-di-AMP-controlled glutamine synthesis pathway promotes persistence of Staphylococcus aureus thymidine-dependent small colony variants in the lung https://www.biorxiv.org/content/10.64898/2026.07.30.741254v1

Session proposals are now open for ASM Microbe 2027 ! asm.org/events/asm-m... If there is a specific topic or speaker you would like to see in Chicago, this is your chance (until Aug 12) ! This is for Micro Symposia and Hub Sessions, but my DMs are open if you have ideas for bigger AEM sessions

Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342

Honored to be elected to the Editorial Board of @asm.org journal #mSphere. I cover Post-Translational Modifications, Bacteriology, Host-Pathogen Interactions, and Toxin/Effector Secretion & Function. Looking forward to working with ASM, and grateful for this opportunity.

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

Out Now! Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens #MicroSky

Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02428-xThis Review summarizes the current knowledge about the cell-intrinsic factors that act against pathogenic bacteria and viruses and the immune evasion strategies that pathogens have to counteract cell-autonomous immunity.

go.nature.com

In situ #CryoEM structures of rice photosystem supercomplexes #photosynthesis #plants #StructuralBiology @nature.com www.nature.com/articles/s41...

In situ structures of plant photosystem supercomplexes - Nature

The cryo‑EM structure of the Oryza sativa photosystem II–light harvesting complex II supercomplex in its native membrane reveals the intact plant photosystem architecture, retaining physiologically re...

nature.com

We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)

Nature@nature.com · 2w ago

Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

Diverse bacterial pattern recognition receptors sense the core phage proteome - Nature

Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural and replicative proteins of bacteriophages.

go.nature.com

Cool method for nano pore based peptide sequencing, nice use of copper-free click chemistry as well! www.nature.com/articles/s41...

Sequential reading of a stepwise-shortened peptide immobilized on nanopore - Nature

A nanopore-based ‘chop and measure’ method sequences peptides at single-amino-acid resolution by using enzymatic digestion to progressively shorten the N terminus one residue at a time,...

nature.com