Joseph Buxbaum, PhD, a principal investigator in the SPARK NS Program, was recently recognized in a SciTechDaily article for research suggesting that Phelan-McDermid syndrome (PMS) may be far more common than previously estimated. ➡️ scitechdaily.com/rare-autism-...
SPARK NS
@sparkns.bsky.social
SPARK NS is an independent nonprofit organization dedicated to advancing promising academic discoveries in Parkinson’s disease and autism from the lab to the clinic. Learn more: https://sparkns.org/
From lab bench to first-in-human trial, the journey of a promising drug is long and complex. One key milestone along the way is the Investigational New Drug (IND) application. Check out our latest News + Insights story: sparkns.org/news-and-ins...
IND Application: Required Before Testing a New Drug in People
A detailed regulatory document that provides evidence that a new drug is safe opens the door to human testing.
sparkns.org
Have you requested your access to the SPARK NS Learning Center yet? You have nothing to lose. It’s free. ➡️ na2.hubs.ly/H06n27-0 In this video, @okornfeld.bsky.social explains why researchers need to think differently about how to advance their discoveries to therapies that can benefit patients.
📣 The July 2026 issue of the SPARK NS Newsletter is here ➝ info.sparkns.org/newsletter-page
SPARK NS Newsletter Page
info.sparkns.org
Most scientific discoveries never make it to patients. Not because the science isn’t promising, but because the drug development process is complex, and rarely taught in academia. That’s why we created the SPARK NS Learning Center. Read our latest article to learn more: sparkns.org/news-and-ins...
SPARK NS Learning Center: Helping More Discoveries Reach Patients
Now all researchers interested in developing therapeutics for autism, Parkinson's, or adjacent conditions can request access to the SPARK NS Learning Center.
sparkns.org
🔔The SPARK NS Learning Center is now available to all researchers interested in or currently developing therapeutics for autism, Parkinson’s, and adjacent conditions. Researchers working in other areas can also request access. *It’s free!* Learn more and request access: na2.hubs.ly/H06n27-0
How do promising therapies reach patients faster than traditional timelines allow? Through programs such as Accelerated Approval and fast-track designations, regulatory agencies are helping to speed access to life-changing therapies while maintaining scientific rigor. sparkns.org/news-and-ins...
A Faster Future for Medicines
From accelerated approval to breakthrough therapy designation, regulators have expanded opportunities for getting promising drugs to patients faster.
sparkns.org
Applications for the SPARK NS Translational Research Program, 2027 Cohort, are now closed! Thank you to everyone who applied! WHAT'S NEXT? Finalists will be notified in Sep with presentations in Oct. The 2027 Cohort will be selected by the end of 2025 and join the program in Jan 2027.
📣Applications for the SPARK NS Program, 2027 Cohort, close on June 5th! Before the deadline, hear directly from researchers already in the program and explore the latest SPARK NS updates in the June 2026 issue of our Newsletter: info.sparkns.org/newsletter-p...
SPARK NS Newsletter Page
info.sparkns.org
Apply by June 5th to be considered for the SPARK NS Translational Research Program, 2027 Cohort. Start your application here ➡️ sparkservices.qualtrics.com/jfe/form/SV_...
Restoring mitochondrial function may offer a new way to treat Parkinson’s. Michael Rape, PhD identified a small molecule that boosts the energy production neurons need to survive. With support from SPARK NS, his team is working to turn this discovery into a therapeutic. sparkns.org/news-and-ins...
Michael Rapé, PhD: Targeting Mitochondria to Treat Parkinson’s Disease
Michael Rapé, PhD: Targeting Mitochondria to Treat Parkinson’s Disease
sparkns.org
If you’re considering applying to the SPARK NS program, start with this. @micharapelab.bsky.social ……. ➡️ Learn more about the SPARK NS Translational Research Program and how to apply: sparkns.org/call-for-pro... ⏳ Application deadline: June 5, 2026, at 5:00 pm PT …….
Working on Parkinson’s or autism therapeutics? SPARK NS is accepting applications! Start yours today: na2.hubs.ly/H05H22c0 ....... ➡️ Learn more about the SPARK Program and how to apply: sparkns.org/call-for-proposals/ ⏳ Application deadline: June 5, 2026, at 5:00 pm PT
Many Parkinson’s and autism discoveries are published in scientific journals. Far fewer reach patients. Why do so many promising discoveries never make it to the clinic? Read the article: sparkns.org/news-and-insights/before-the-deadline-hear-from-researchers-inside-the-spark-ns-program/
Before the Deadline, Hear from Researchers Inside the SPARK NS Program
PIs in the SPARK NS program reflect on the challenges, expertise, and support needed to move Parkinson’s and autism discoveries toward patients.
sparkns.org
New findings from Alice Chen-Plotkin, MD, Parker Family Professor of Neurology, @upenn.edu, and a principal investigator in the SPARK NS program point to a potential new path toward slowing #ParkinsonsDisease progression. @alicechenplotkin.bsky.social www.cell.com/neuron/fullt...
Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies
GPNMB, encoded by a Parkinson’s disease (PD) risk gene, is secreted by microglia in response to neuronal damage. Microglia-derived GPNMB can enhance uptake of pathological forms of alpha-synuclein—the...
cell.com
⏳ Final hours to request an Optional Pre-Submission Review for the SPARK NS program. Submit your request by this Tuesday, May 12 at 5pm PT. ➡️ lnkd.in/gWN_AqhU
The best reasons to apply to the SPARK NS program don’t come from SPARK NS. Hear below a message from Miratul Muqit, PhD, Professor of Experimental Neurology, University of Dundee, and Director of UK Dementia Research Institute Parkinson’s Research Centre, University of Edinburgh. @ukdri.ac.uk
📣Get early feedback before applying to the SPARK NS program + hear inspiring stories from Parkinson’s researchers. The May issue of the SPARK NS Newsletter is out: info.sparkns.org/newsletter-page
Every Parkinson’s researcher has a different starting point. Some started in a moment with a patient. Others were inspired in a university or medical school course. One started by watching a television show! Learn more about the SPARK NS program and how to apply: lnkd.in/gy_nsHFU #Parkinsons
Wondering if you should apply to the SPARK NS program? Here’s a message from Timothy Ryan, PhD, an investigator in the program now. ➡️ Learn more about our program and how to apply: sparkns.org/call-for-pro... Application deadline: June 5, 2026, at 5:00 pm PT #ParkinsonsDisease #autism
In our latest News + Insights article, we explore how a well-planned target product profile (TPP) can serve as a roadmap for researchers, aligning scientific vision with regulatory, clinical, and business goals. sparkns.org/news-and-ins...
Target Product Profile: Key to Success in Drug Development
A new therapeutic breakthrough is never guaranteed, but a comprehensive, thoughtful plan can help.
sparkns.org
We spoke with principal investigators in the SPARK NS program about their paths into the field, the turning points that shape their work, and what continues to drive them as they seek to develop new therapeutics. Read our News + Insights story: sparkns.org/news-and-ins...
Behind Every Parkinson’s Researcher, There’s a Story
Stories, turning points, and motivations shaping the next generation of therapeutics for Parkinson’s disease.
sparkns.org
SPARK NS seeks academic researchers developing autism and Parkinson’s therapeutics. Up to $2M funding plus translational support. Apply by 5 June 2026. www.dementiaresearcher.nihr.ac.uk/funding/spar...
SPARK NS Translational Research Program
SPARK NS seeks academic researchers developing autism and Parkinson’s therapeutics. Up to $2M funding plus translational support. Apply by 5 June 2026.
dementiaresearcher.nihr.ac.uk
Heck of an opportunity for #Parkinsons research - calls for SPARK-NS Translational Research Program, 2026 Cohort are now open! Up to $2M in milestone-based funding, education, mentoring, & networking opportunities over two years, beginning January 2026 sparkns.org/call-for-pro...
Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work! sparkns.org/programs/pro...
Projects
sparkns.org
Congratulations to the latest batch of Principal Investigators to join the SPARK NS Program 2026 cohort - 9 new projects exploring #Parkinsons or Autism sparkns.org/news-and-ins...
SPARK NS invites principal investigators with promising discoveries in #Parkinson’sDisease & #autism in the US, Canada, the UK, and Europe to apply for the SPARK NS Translational Research Program, 2027 Cohort. ⏰ Application deadline: June 5, 2026, at 5:00 pm PT Info: sparkns.org/call-for-pro...