🧬 Delighted to share our new Nature Communications paper! We show how MCM2-7 double hexamers become active helicases and trigger DNA melting in vivo. Led by Chris Weekes & L. Maximilian Reuter. Congratulations to the whole team! doi.org/10.1038/s414... #DNAReplication

Very upsetting to hear the sad news of Greg Hannon’s passing. I always enjoyed our far too few conversations we had over the years. He had an interesting and insightful perspective on any science being discussed. He will be missed. www.cruk.cam.ac.uk/news/in-memo...

In Memoriam: Professor Greg Hannon (1964–2026) - Cancer Research UK Cambridge Institute

Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.

cruk.cam.ac.uk

📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch. #PhDStudentship #LifeSciences #DNAReplication #CRISPR

Christian Speck@speck-lab.bsky.social · 8mo ago

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin

🚨 Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.

Christian Speck@speck-lab.bsky.social · 8mo ago

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin

PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of Cancer Research o...

PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...

findaphd.com

Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?

A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.

Study reveals the hidden benefits of weight loss on fat tissue

Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...

lms.mrc.ac.uk

Still time to apply for the MRC LMS Emerging Innovators Fellowship for scientists of Black heritage!!!

MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · last yr.

There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage! If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply. Applications close 11 May 2025. Find out more 👇

📢To all postdocs. Are you ready to start your semi-independent career? The BBSRC Fellowship call is open. We may host you if you work at the interface of DNA replication/chromatin biology/cancer and like to use protein biochemistry, genomics, cryo-EM, AlphaFold, MD... www.ukri.org/opportunity/...

2024 BBSRC Fellowships scheme

Apply for funding to carry out independent research within a host laboratory and gain leadership skills.

ukri.org

700,000 women are to be recruited to take part in an NHS AI breast cancer screening trial in England. Five different AI platforms will be tested across 30 sites from April to see if the technology can speed up diagnosis as well as free up radiologists. www.bbc.com/news/article...

Major breast cancer screening AI trial to begin - BBC News

Almost 700,000 women to be recruited to study as government fires starting gun on cancer strategy.

bbc.com

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...

I was waiting for that...

AlphaFold Unofficial@alphafold.bsky.social · 2y ago

New AI system designs proteins that successfully bind to target molecules, with potential for advancing drug design, disease understanding and a system for designing novel, high-strength protein binders to serve as building blocks for biological and health research. deepmind.google/discover/blo...

The Baker Lab (@uwproteindesign.bsky.social) recently hosted this powerful webinar on computational #proteindesign. Take a journey through the history of this groundbreaking field, guided by some of the greats! 🧬🧶 #alphafold #proteomics #proteinscience www.youtube.com/live/BuJGTn7...

📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea. Supervised by me, @Steve Quinn & @georgerheath.bsky.social www.findaphd.com/phds/project... Open to Applicants Worldwide! 📅 January 6, 2025 #microsky #archaeasky