Calling #GameofThrones fans! The May '26 issue of Trends in Microbiology is live now with the cover image depicting the intimate co-evolution between the host and the microbiota. Read the full issue here: www.cell.com/issue/S0966-...

Reposts appreciated! What if standard lab mice miss the real microbial game? Honored to be featured on the May cover @cp-trendsmicrobiol.bsky.social: „The microbial companion.“ Our paper “Game of Microbes: A Wildling’s Guide” is out now: dlvr.it/TRl1Zs Thread below with more @cellpress.bsky.social

Game of microbes: a wildling’s guide

Game of microbes: a wildling’s guide

Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure and interactions with commensal and pathogenic microorganisms. In contrast, wild mice encounter diverse microbial environments, undergo natural selection, and rely on robust immune responses for survival. Consequently, lifelong microbial exposure is a key driver in shaping mammalian physiology, establishing the need for naturalizing rodent models in biomedical research. By defining the concepts of ‘microbial self’ and ‘microbial nonself’, we propose a four-step guide for establishing a multigenerational wildling colony that accounts for both microbial self and microbial nonself. This reestablishes the common biological link shared by all free-living mammals, thereby improving the comparability between murine and human studies.

dlvr.it

Please share! Ever wondered how to establish and maintain wildlings – and why they matter? Our new paper “Game of microbes: a wildling ’s guide” is now out in Trends in Microbiology dlvr.it/TRl1Zs - Thread below with key previous work @cp-trendsmicrobiol.bsky.social @cellpress.bsky.social @FAU.de

Game of microbes: a wildling’s guide

Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure a...

dlvr.it

Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

Proud PI moment: first preprint from the Torow lab🔥. Four years ago @eva-stange.bsky.social set out to map T cell dynamics in the neonatal liver—what a ride. A genuinely collaborative effort, and a special shout-out to Mathias W. Hornef for outstanding mentorship.

Eva-Lena Stange@eva-stange.bsky.social · 7mo ago

Excited to share the preprint of my PhD work with @ntorow.bsky.social! We asked what T cells in the neonatal liver are doing. Main takeaways: they’re activated before weaning (unlike in most organs), show distinct microbial sensitivity, form microclusters, and have long-term consequences. 🧵⏬(1/10)

Recent podcast with ImmunoTea Time tinyurl.com/4zrdvbrb m.youtube.com/watch?v=8yxs... Thank you for the chat😀👍 doi.org/10.1038/s414... doi.org/10.1126/scie... www.science.org/doi/10.1126/... www.cell.com/trends/immun... www.cell.com/fulltext/S00...

Where the wildlings are ft. Prof. Dr. Stephan Rosshart

ImmunoTea Time · Episode

tinyurl.com

Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

Please share! Great work led by Sangya and Robert published @jem.org hubs.la/Q03wg9cr0 Thank you for allowing us to contribute! @sfb1160.bsky.social #wildlings doi.org/10.1038/s414... doi.org/10.1126/scie... www.science.org/doi/10.1126/... www.cell.com/trends/immun... www.cell.com/fulltext/S00...

Gut microbiota–derived TMAVA is a modulator of acute CNS-GVHD

In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activati

hubs.la

Journal of Experimental Medicine@jem.org · last yr.

Chatterjee, Zeiser et al. @dkfz.bsky.social report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration. rupress.org/jem/article/...

Please share! Hiring PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

#GastroEdPick Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype www.nature.com/articles/s41... #Gastrosky #Microsky

Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype - Nature Communications

Here, the authors apply a standardized system, called TXsystem, to transplant wild mouse gut microbiota into SPF mice, developing “TXwildlings” mice that stably retain natural microbiota and human-lik...

nature.com

Please share our latest work @natcomms.nature.com „ONE MICROBIOTA TO RULE THEM ALL“ doi.org/10.1038/s414... A big THANK YOU to the entire team of great scientists! #wildlings doi.org/10.1126/scie... www.science.org/doi/10.1126/... www.cell.com/trends/immun... @fau.de @Hornegger.bsky.social