Glad to share our latest publication in Science! This work reports: 🧬 the first single-cell 3D genome atlas of human tonsil and B cell immunity, 🧬 a new function for cohesin loop extrusion, and 🧬 a novel chromatin "curl" structure. www.science.org/doi/10.1126/...

A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation

B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influen...

science.org

Thank you the student union of the biochemistry department and Professor Ahilya Sawh @hilsawh.bsky.social of the University of Toronto for inviting me to present in the George Connell Lecture Series! It was so wonderful to meet and discuss science with colleagues and students in the esteemed UofT.

Read our @natgenet.nature.com News&Views on the impressive work by @muzumdarlab.bsky.social and @sstevenwang.bsky.social. How does the 3D genome guide Kras-driven cancers evolution? Find out with single-cell genome-wide chromatin tracing! 📖https://rdcu.be/eShAY

Muzumdar Lab@muzumdarlab.bsky.social · last yr.

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

Thank you Dian and Xuebing for inviting me to visit the Department of Systems Biology at Columbia. Such engaging and inspiring audience at the talk. It felt like everyone had asked at least one question by the end. Thank you all for having me and for this invigorating day of scientific exchanges!

Columbia Systems Biology@columbiasysbio.bsky.social · 10mo ago

We are thrilled to welcome Dr. @sstevenwang.bsky.social (hosted by Drs. Dian Yang and @xuebingwu.bsky.social ) from @yalemedicine.bsky.social . Seminar "Image-based Spatial Omics" will be from 3-4pm in ICRC 816.

Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.

Cell - a Cell Press journal@cp-cell.bsky.social · 12mo ago

Now online! Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

YouTube video by GenomeTDCC

youtube.com

🎉PUBLISHED @natgenet.nature.com 📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers. By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics

This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...

nature.com

New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers. ➡️ yalecancercenter.org/news-article...

Cancer's Progress Detailed by 3D Genomic Maps

Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced

yalecancercenter.org

Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12

Check out this new video highlighting our lab :-) Thank you @yaleschoolofmed.bsky.social Video Team for the production! m.youtube.com/watch?v=p-hE...

Genome Architectures & Spatial Transcriptomics - The Siyuan Wang Lab at Yale School of Medicine

YouTube video by Yale Medicine

m.youtube.com

How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...

A Brief History of Contemporary 3D Genomics Technologies

YouTube video by GenomeTDCC

youtube.com

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8