We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime www.epfl.ch/labs/dangelo...
Master Projects
DANGELOLAB
epfl.ch
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...
cell.com
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Thrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
science.org
Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1... Happy testing: cryosift.org #cryoEM #CNN
Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025... Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.social
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelit...
doi.org
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus
biorxiv.org