Kinga Kamieniarz-Gdula
@stoplab.bsky.social
Molecular biologists fascinated by gene ends. PI at IBMiB and CAT, Adam Mickiewicz University in Poznan, Poland. Oxford University and @mpi_ie Freiburg alumna. STOPlab.org
Big conferences are impressive. But how often do you actually meet someone there? 🤔 The Epigenetics Meeting was created differently. We have a great line-up of speakers with exciting research topics, ample time for discussion, and very familiar setting. Join us now: events.ie-freiburg.mpg.de
Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome pubmed.ncbi.nlm.nih.gov/42420270/ #cryoEM
Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!
Structure and evolution-guided design of minimal RNA-guided nucleases
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...
science.org
Join us at the "Cancer Research Across Scales" conference at the Weizmann Institute of Science! Many Israelis living abroad may be in Israel that week for the national election, so help us spread the word!
DNA G-quadruplexes are dynamic four-stranded #DNA knots that may control genes, protect genomes, and drive disease, yet are poorly understood. This Unsolved Mystery by Irene Gallina & Sara Richter investigates their origins and functions. 🧪 #AcademicSky plos.io/4aXJXNC
![Structure and chemistry of G-quadruplexes (G4s). Structure of a duplex-G4-duplex DNA molecule (image from the RCSB PDB (http://www.rcsb.org/) of PDB ID 8DUT [4]). Duplex DNA is depicted in purple and dark green; G4 DNA is depicted in yellow, and both side and top views of the G4 structure are shown. The displaced strand opposite the G4 has been omitted for clarity. A. Chemistry of Watson-Crick hydrogen bonds between complementary cytosine and guanine on duplex B-DNA. B. Chemistry of planar Hoogsteen hydrogen bonds between four guanines within a G-tetrad. Guanines in a tetrad are usually coordinated by a monovalent cation such as potassium (K+). Created in BioRender; credit to Gallina, I. (2026)](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreie6zo3dm7joyzvvh4vbf6w64sackwg3zul7442yh2mvb5mpodsvoa)
GOOD NEWS! Phase I clinical trial results out of John Hopkins show a first-of-its-kind vaccine designed to target common KRAS mutations was safe AND stimulated KRAS-specific T-cell responses in 90% of study participants who were at HIGH risk of developing pancreatic ductal adenocarcinoma (PDAC).
Pancreatic Cancer Vaccine Triggers Immune Response Before Tumors Develop
Phase I results show early promise for a vaccine designed to prevent pancreatic cancer in people at high risk of developing the disease.
insideprecisionmedicine.com
🧬 New paper in Nature Structural & Molecular Biology! @agatakstepien.bsky.social, Martyna Plens-Gałąska & @stoplab.bsky.social authored a News & Views piece on transcriptional readthrough, showing how this cellular process links to anti-cancer drugs & new therapies 👏 www.nature.com/articles/s41...
Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity - Nature Structural & Molecular Biology
Several anti-cancer drugs delay transcription termination, triggering transcriptional readthrough. Readthrough has long been considered an incidental transcriptional byproduct, however a recent study ...
nature.com
Really appreciate @agatakstepien.bsky.social and Kinga @stoplab.bsky.social for surprising us with this kind shout out to our work! I love how they pull together these important pieces of an emerging puzzle!
Agata Stepien@agatakstepien.bsky.social · last mo.Studying gene ends is becoming even more fascinating! Curious why? Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication by Podszywałow-Bartnicka and @karlaneugebauer.bsky.social @natsmb.nature.com
Here is the link to our paper! pubmed.ncbi.nlm.nih.gov/41860998/
Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib - PubMed
Cellular stresses regulate transcriptional readthrough, whereby RNA polymerase II elongates past a gene's polyadenylation cleavage site without RNA cleavage. Readthrough has been reported in several c...
pubmed.ncbi.nlm.nih.gov
There is more to transcriptional readthrough than meets the eye, and it could even provide a therapeutic opportunity in cancer. Check out our new perspective, inspired by recent work from Neugebauer and Grzechnik labs! #RNABiology #RNASky #Epigenetics
Agata Stepien@agatakstepien.bsky.social · last mo.Studying gene ends is becoming even more fascinating! Curious why? Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication by Podszywałow-Bartnicka and @karlaneugebauer.bsky.social @natsmb.nature.com
“Killer” is too kind. Musk is a mass murderer. He’s disrupting democracies around the world. Not to mention the “mechahitler” white-supremacist misogyny machine of Grok & X. I witnessed firsthand the cruel, ignorant, wasteful destruction at NASA at the hands of DOGE. www.theverge.com/tech/949259/...
The world’s first trillionaire is a killer
Elon Musk’s empire of wealth is built on suffering.
theverge.com
Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!
1/8 Inside your body lies something ancient. Our @pnas.org paper uncovers the deep unicellular prehistory of blood cell types. See paper and video. @ibe-barcelona.bsky.social @icreacommunity.bsky.social @prbb.org @csic.es @csicdivulga.bsky.social pnas.org/doi/10.1073/...
We are allocating an extra €15 million in humanitarian assistance to support the response to the Ebola outbreak affecting the DRC and Uganda. Safeguarding public health remains our priority as diseases do not stop at borders and cooperation is essential. link.europa.eu/BwQRMc
Do you have a manuscript with reviews from another journal? We can use them to fast track a decision on your submission. Read more journals.biologists.com/dev/pages/jo...
SETD2 aids gene definition by acting on both its beginning and end - yet in a gene specific way. Proud of this new work from the lab! @uam-ibmib.bsky.social @emboreports.org #chromatin #RNAbiology
Magda Kopczyńska@mgkopczynska.bsky.social · 4mo agoOur paper (@stoplab.bsky.social), in collaboration with the Nojima lab (@pol2rna.bsky.social @chiheron.bsky.social), on the role of chromatin modifier SETD2 at both ends of the transcriptional cycle, is now published in @emboreports.org 🪅 (1/5) link.springer.com/article/10.1...
Our paper (@stoplab.bsky.social), in collaboration with the Nojima lab (@pol2rna.bsky.social @chiheron.bsky.social), on the role of chromatin modifier SETD2 at both ends of the transcriptional cycle, is now published in @emboreports.org 🪅 (1/5) link.springer.com/article/10.1...
Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen
Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social Details in the thread below - please share! Deadline 8th May 2026, fully funded for UK Home students (1/4)
The Angel of Death did not find Chuck Norris. Chuck Norris found the Angel of Death. Remembering the best (fictional) martial arts fight ever captured on film: www.youtube.com/watch?v=NlTy...
www.theguardian.com/commentisfre...
The Guardian view on the cost of Trump’s war on Iran: the world’s poor will pay most dearly | Editorial
Editorial: The economic fallout of the US-Israeli assault and Tehran’s retaliation is spreading fast, and pushing the most vulnerable towards disaster
theguardian.com
Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
science.org
This Friday at the @uam-ibmib.bsky.social seminar: Katarzyna Klonowska from the Institute of Biooganic Chemistry PAS in Poznan will give a talk on mutation landscape in tumour suppressor gene syndromes - join us!
We’re recruiting! Three-year, fully funded #postdoc opportunity: pancreatic cancer #epigenetics & potential new treatments (funded by @ncn.gov.pl & @dfg.de ). Collaboration with @akispapantonis.bsky.social, University of Göttingen (OPUS-LAP). See the ad & contact me! drive.google.com/file/d/1vrFd...
Scientists have found a little RNA molecule – small enough to potentially form spontaneously, yet sophisticated enough to copy itself – that cd explain how life on Earth arose. Thanks @edogia.bsky.social of the @philholliger.bsky.social lab! blog.sciencemuseum.org.uk/in-the-begin...
In the beginning - Science Museum Blog
A tiny self-copying molecule offers the clearest answer yet to the mystery of the origins of biology, reports Science Director Roger Highfield.
blog.sciencemuseum.org.uk
