Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

I have an open Postdoc position in Molecular Systems Biology at ETH Zürich! The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠 More details and application at: jobs.ethz.ch/job/view/JOP... Please share!

Postdoctoral Position in Molecular Systems Biology

jobs.ethz.ch

(1/3) Antibiotic resistance is costing human lives. 🦠 A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪 www.nature.com/articles/s41...

a triangle 🔺 it’s a basic shape, but no bacteria is a triangle a clothes hanger, a slice of pizza, a dorito—all triangles just not bacteria

If there is one account worth following irrespective of your reasons for being on Bluesky, it is @auschwitzmemorial.bsky.social. A humbling and necessary constant reminder of the human abyss.

Auschwitz Memorial@auschwitzmemorial.bsky.social · 2y ago

We are on @bsky.app. Please consider following @auschwitzmemorial.bsky.social where every day we commemorate the victims & educate about the tragic human history of Auschwitz. Repost please.

Trying to purify and sequence #phage for phage therapy? Try #sphae a new approach to identify if your phage could be useful for treatment #phagesky

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 2y ago

Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1

My first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

EMBL Jobs

We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

embl.org

To fill up my empty feed, my first post on #bluesky. Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL). www.science.org/doi/10.1126/...

Woohoo, the Microbiology Department (this includes me) at the JLU Giessen is looking for a new colleague (W2 with tenure track to W3). Look here: uni-giessen.de/karriere/ste... (and yes, knowledge of the German language is required ...). Come to Giessen! We have cookies.

A new class of immune signaling molecules generated by TIR domains: histidine conjugated to ADP-ribose Check out our preprint: tinyurl.com/hisADP A fantastic collaboration with the Tamulaitiene and Kranzusch labs

Can a phage defence system interfere with antibiotic action? 💊 Yes, it can! CBASS is triggered by antifolates and turns these mostly bacteriostatic drugs into bactericidal ones in bugs like V. cholerae. 🦠 www.nature.com/articles/s41564-023-01556-y Read full here: rdcu.be/du20r

The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibi...

High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs...

nature.com

Thank you Tim Blower and Stineke van Houte for an awesome news and views!🎁🎁 #phagesky

Viruses wrap up bacterial defence systems

Bacteria use diverse defences against viral predators called bacteriophages. A method to identify antibacterial counter-defences in viral genomes has revealed striking modes of defence inhibition. Pre...

nature.com

Love this research highlight on our recent papers!🥊👊 @soreklab.bsky.social #phagesky nature.com/articles/s41...

A never-ending defence fight - Nature Reviews Microbiology

Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity...

nature.com

Gift link to NYT article on an exciting breakthrough in treating extreme nausea in pregnant women (+ cancer patients). The female MD who conducted the breakthrough study (a) lost her pregnancy at 15 weeks gestation after suffering & (b) was told the problem was in her head. Representation matters.

Scientists Pinpoint Cause of Severe Morning Sickness

The discovery could lead to better treatments for severe nausea and vomiting during pregnancy.

nytimes.com

PIRATES!! Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1

this is a bloody great name for a climate report www.unep.org/resources/em...

If I'm already on it, another tool I use when encountering a hypothetical uncharacterized protein is CDVist by the Zhulin lab. Great to predict domains and easy to use. Inviting rabbit holes included. 😅 cdvist.joulinelab.org

I started a #phage feed ... #phagesky Add that hashtag to your posts to be included on the feed

One of the tools I find useful to get to know a new protein: PaperBLAST will find papers where your protein of interest has been described before. papers.genomics.lbl.gov/cgi-bin/litS...

The scientific, economical, and regulatory roadblocks to #phage therapy - the example of Germany www.mdpi.com/1999-4915/15...

Phage researchers, could you help out? Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?

Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1

Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1

Antiviral defence systems build the prokaryotic immune system and their proper regulation is vital f

biorxiv.org

The strain on scientific publishing 📄: We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!? See: arxiv.org/abs/2309.15884 A 🧵1/n #AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat

I'm really looking forward to this meeting next week! It's been a great group of labs & projects and so many interesting presentations at the last meetings!

Can we limit infection by disarming pathogens rather than killing them? In this review we discuss the current state of play with this approach to tackle antibiotic resistance. www.nature.com/articles/s44...

Professorin oder Professor (w/m/d) für »Mikrobielle Physiologie« at TU München deadline: 30.09.2023 portal.mytum.de/jobs/profess...