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Suraj Shankar 🏳️‍🌈

@surajshankar.bsky.social

Asst. Prof. in Physics LSA Collegiate fellow University of Michigan Previously JF at Harvard & PhD at SU he/him https://sites.lsa.umich.edu/shankar-lab/ How function emerges collectively in soft, active, living matter? | Physics, maths, & biology

24 Posts1061 Follower1002 Folgt
Henry Gee 亨利·纪@endofthepier.bsky.social · 2mo ago

It hasn't the cultural resonance of the 1st interracial kiss on TV, but the first trans-phylum transplant has to be a milestone in the discovery that ctenophores have a blastoporal organiser. And surgery on ctenophores must be like catching clouds. Paper in @nature.com www.nature.com/articles/s41...

A blastoporal organizer in a ctenophore - Nature

Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...

nature.com

Ben Larson@blarson.bsky.social · 3mo ago

And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...

Scanning electron microscopy image of the ciliate Euplotes gigatrox on the cover of the journal PNAS. Distinct punk rock vibes
Ben Larson@blarson.bsky.social · 11mo ago

What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells? www.biorxiv.org/content/10.1... Video by Vittorio Boscaro. 1/n

Will Ratcliff@wcratcliff.bsky.social · 3mo ago

1/35 New preprint! We show that obligate multicellularity removes fundamental population genetic barriers to multicellular adaptation. Even a brief unicellular phase can dramatically constrain the evolution of beneficial multicellular traits. www.biorxiv.org/content/10.6...

Obligate multicellularity circumvents population genetic barriers to collective-level adaptation

Complex multicellularity has evolved in just five lineages (animals, plants, brown algae, red algae, and fungi) and in each case, these organisms develop clonally and are obligately multicellular. While prior work has shown that clonal development plays a critical role in the evolution of complex multicellularity, none has disentangled this from the impact of obligate vs facultative multicellular life cycles. Here we use experimental evolution with engineered snowflake yeast ( Saccharomyces cerevisiae ) to directly test how life cycle structure affects multicellular adaptation. We created isogenic strains capable of switching between unicellular and clonal multicellular phases, then evolved populations for 192 days under obligately multicellular, facultatively multicellular, and obligately unicellular regimes. Obligately multicellular populations rapidly evolved larger size, primarily driven by a whole genome duplication, in all five replicates. Facultative populations showed dramatically constrained evolution, with tetraploidy evolving in only 2/10 facultative populations despite experiments demonstrating that it is strongly beneficial across the full life cycle. Mathematical modeling reveals the mechanistic basis for this constraint: facultative life cycles create establishment barriers through two population genetic effects. Group formation dramatically reduces the number of units of selection, making beneficial multicellular mutations vulnerable to drift. This asymmetry in population size between life cycle phases also allows cell-level selection to overpower group-level selection, eliminating mutations that provide group-level benefits but carry cell-level costs. These findings demonstrate that obligate multicellularity circumvents fundamental population genetic barriers to collective-level adaptation, helping explain why complex multicellularity has evolved exclusively in obligately multicellular lineages, and suggesting similar constraints may operate in other evolutionary transitions in individuality. ### Competing Interest Statement The authors have declared no competing interest. U.S. National Science Foundation, https://ror.org/021nxhr62, DEB-1845363 Howard Hughes Medical Institute Gilliam Fellowship National Science Foundation Graduate Research Fellowship

biorxiv.org

eric lai@lucksmith.bsky.social · 3mo ago

this review topic is so metal. and also very @currentbiology.bsky.social! 🤘 one thing i didn't appreciate is that one advantage of "ballistic tongues" is that they operate over a broader temperature range than muscle shortening action. www.cell.com/current-biol...

Ballistic tongues

Zeng and Deban provide an overview of ballistic tongues in three vertebrates, highlighting similarities and differences in launch and retraction mechanisms, ecological advantages, evolutionary history...

cell.com

Nicoletta Petridou@nicolettapetridou.bsky.social · 3mo ago

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

Tissue rigidity phase transition shapes morphogen gradients - Nature Cell Biology

Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...

nature.com

Nicoletta Petridou@nicolettapetridou.bsky.social · last yr.

Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org

Sean D. Johnson@seanjohnson.bsky.social · 3mo ago

It seems the university may not have been entirely honest in suggesting that they were caught unaware. I’m shocked, shocked I say! In fact, Prof. Peterson said they were aware and that he modified some language based on their feedback. www.insidehighered.com/news/faculty...

Professor’s Praise for Pro-Palestine Protestors Sparks Furor

Republican officials and some Jewish groups criticized the speech as antisemitic and unnecessarily political.

insidehighered.com

Sean D. Johnson@seanjohnson.bsky.social · 3mo ago

Is the implication that the university would have censored Prof. Peterson if these remarks were in the draft he sent to the university before convocation? Academic freedom aside, we are a public institution, and there is an amendment for that sort of crap.

Armita Nourmohammad@thearmita.bsky.social · 3mo ago

check out our new work on the design principles underlying cytotoxic T-cell responses. how do trade-offs and cell economics shape immune decision making? led by Obinna Ukogu and in collaboration with Grégoire Altan-Bonnet. www.pnas.org/doi/10.1073/...

Design principles of the cytotoxic CD8+ T cell response | PNAS

Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studi...

pnas.org

Pau Guillamat@pauguillamat.bsky.social · 4mo ago

Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...

Science | AAAS

science.org

Pau Guillamat@pauguillamat.bsky.social · last yr.

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

Aissam Ikmi@aikmi.bsky.social · 5mo ago

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

Deciphering mechanical determinants of morphological evolution

A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these m...

cell.com

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