SyNergy - Munich Cluster for Systems Neurology
@synergy-munich.bsky.social
SyNergy studies how complex neurological diseases like Alzheimer's, Parkinson's, stroke, and MS develop. By exploring shared mechanisms with a systems neurology approach, researchers aim to uncover new therapies. Funded by the DFG since 2012.
🧠 How dendrites help neural circuits learn without forgetting: Researchers developed a biologically grounded computer model showing how #dendrites and inhibitory neurons can control where #synaptic changes occur. 🔗Read a summary on our website: www.synergy-munich.de/news-events/...
🧠 A reproducible 3D human brain tissue model (#3BTM) with mature #microglia to investigate #Alzheimer's disease. New publication by SyNergy member Dominik Paquet and SyNergy colleagues in #NatureNeuroscience. 🔗Read a summary on our website: synergy-munich.de/news-events/...
SyNergy Mitglied Magdalena Götz erzählt in einem neuen Podcast über ihre Arbeit zu neuronalen Stammzellen in der regenerativen Medizin. 👇
Der Code des Lebens@dercodedeslebens.bsky.social · last mo.📣 Neue Podcast-Folge 📣 Prof. Dr. Magdalena Götz vom @helmholtzmunich.bsky.social berichtet über unterschiedliche Stammzelltypen sowie die besondere Bedeutung neuraler Stammzellen. 🎧 Hier gehts zur Folge: codedeslebens.podigee.io/57-stammzellen #Genetik #Forschung #Podcast #Wissenschaft #GHGA
🧠 Nuclear #MAP1B Links Cytoskeleton and Cell Fate. Magdalena Götz and her team mapped the nuclear and cytoplasmic proteomes of #neuralstemcells and discovered that many cytoskeletal proteins are present in the nucleus. 🔗Read a summary on our website: www.synergy-munich.de/news-events/...
🧠 A Simple MRI Marker for Earlier #PSP Diagnosis. Progressive supranuclear palsy is difficult to distinguish from #Parkinson’s disease and other parkinsonian disorders, especially early in the disease course. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Bei #Alzheimer ist ein bestimmter Bereich im Gehirn besonders früh von Veränderungen betroffen: der so genannte Locus Coeruleus. Dr. Lars Paeger vom @dzne.science erforscht, warum das so ist und was passiert, wenn die Energieversorgung in den Nervenzellen gestört ist. ▶️Mehr Infos gibt's im Video
Was passiert im Gehirn zu Beginn einer Alzheimer-Erkrankung?
YouTube video by Alzheimer Forschung Initiative
youtu.be
🧠 Many diseases affect the whole body, but studying these changes at cellular resolution has remained difficult. We developed #MouseMapper, a deep-learning framework that maps #nerves and more in entire mouse bodies. 🔗Read a summary of the study on our website: synergy-munich.de/news-events/...
🧠 Metabolic #Tau Toxicity Drives Neuronal Death: This study shows how reduced brain glucose metabolism and pathological phosphorylated Tau cooperate to trigger neuronal #necroptosis. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Advanced Clinician Scientist Program for Comprehensive Neuroscience (PROMISE) www.med.lmu.de/de/wissensch...
🧠 Engineered Human Neurons Model Late-Stage #Tauopathy. This study presents a human induced pluripotent stem cell ( #iPSC )–based neuronal model that reproduces key features of late-stage tauopathies. 🔗Read a summary of the study on our website: synergy-munich.de/news-events/...
🧠Single-synapse mechanisms shape #visualperception. This study reveals how thalamic inputs to the #primaryvisualcortex operate at individual #synapses 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
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Center for Advanced Studies@caslmu.bsky.social · 6mo agoCome and join Nobel laureate Paul Nurse, President @royalsociety.org, and philosopher Christof Rapp @caslmu.bsky.social @lmu.de in exploring one of the most fundamental questions in science: What is Life? Save the date: 17 April, 16:15📍LMU, main building register: info@cas.lmu.de, www.cas.lmu.de
🧠Constitutive neuronal expression and disease-associated upregulation of #chitinases in #amyotrophiclateralsclerosis 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
🧠 #CSF #proteomics sharpens #multiplesclerosis diagnosis. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
New paper out: TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.: Feiten, Astrid Feentje; Dahm, Kilian; Schlepckow, Kai; et al. Nature Communications Vol. 17, no. 1, p. 2002 | Thanks for sharing #dzne #papers
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.
Feiten, Astrid Feentje; Dahm, Kilian; Schlepckow, Kai; et al. Nature Communications Vol. 17, no. 1, p. 2002
dlvr.it
🧠 Synaptic #Dopamine Storage Defect Uncovered as Key Mechanism in #Parkinson’s Disease Neurons. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
🧠CD38 Shields #CNS Tregs From Post-Inflammatory Stress. The study shows that regulatory #Tcells persist in the CNS after the acute phase and are essential to prevent local relapses. 🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...
🧠 TREM2 Levels Shape Microglial Metabolic Fitness. This study shows that microglial #TREM2 is not an on/off signal but a graded axis that tracks with microglial state and function. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Outstanding work! – Congratulations to SyNergy member Fabian Theis!
Fabian Theis@fabiantheis.bsky.social · 7mo agoCellRank protocol now in @NatureProtocols! 🎉 @PhilippWeiler's detailed guide shows how to: - Integrate velocity, pseudotime & time points - Infer cell fate probabilities - Analyze lineage priming at scale Great complement to our CellRank 2 paper! 📖 www.nature.com/articles/s41...
🧠 Zebrafish compass neurons learn visual anchoring. Using panoramic virtual reality and two-photon imaging, we show that larval #zebrafish head-direction neurons track complex visual scenes. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
🧠✨ Dive into #neurodegeneration at the SyNergy #ScienceDay on February 3, 2026! (in German) Medical students get inspiring talks, expert discussions, and an emotional #Alzheimer film through Cineducation. Curious? Join the journey from lab to clinic! #MedicalStudents #TranslationalTeaching
🧠New blood test shows the extent of brain injury after #stroke – and reveals treatment effects. Bood #biomarker brain-derived #tau (BD-tau) can track acute brain injury after ischemic stroke over time. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Neuer Kurs: Die #Alzheimer-Erkrankung – Dieser Kurs richtet sich an alle, die sich für das Thema Alzheimer interessieren: an Sie als Betroffene, Angehörige, interessierte Laien oder medizinische Fachkräfte. In Zusammenarbeit mit dem SyNergy Cluster. www.synergy-munich.de/aktuelles/ne...
🧠 Fully human #iPSC - derived 3D #BBB model with perfusable vessels and key BBB functions. #FOXF2 deletion causes BBB dysfunction, rescued by lipid-nanoparticle delivery of Foxf2 mRNA. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
🧠 ApoE4 lowers the p-tau217 #tauopathy threshold. In two independent cohorts spanning preclinical and symptomatic #Alzheimer’s disease, the study tested where #ApoE4 accelerates the amyloid-to-tau transition. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Welche Prinzipien der Intelligenz verbinden Mensch, Tier und Roboter? Hört rein in die nächste Folge des #Podcast #exzellenterklaert – Spitzenforschung für alle! Das Cluster Science of Intelligence erklärt. warum Grundprinzipien von Intelligenz wichtig sind. exzellent-erklaert.podigee.io #Wisskomm
Exzellent erklärt - Spitzenforschung für alle
57 Exzellenzcluster – ein Podcast: Regelmäßig berichtet „Exzellent erklärt“ aus einem der Forschungsverbünde, die im Rahmen der Exzellenzstrategie des Bundes und der Länder gefördert werden. Die Reise...
exzellent-erklaert.podigee.io
🧠 In vivo #CRISPR screening approach identifies cytokine networks that control #macrophage function in #neuroinflammatory lesions, offering new insights into immune regulation in diseases such as #multiplesclerosis 🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...
👏 Our member Qihui Zhou, has received a grant of 100,000 Swiss francs from the Frick Foundation. Zhou and her team will take a closer look at the role of the immune system in the most common genetic form of ALS. 🔗https://www.dzne.de/en/im-fokus/meldungen/2025/funding-for-munich-als-researcher/
