Thrilled to be co-organizing the 2027 FASEB Science Research Conference on Vasoregulation: Signaling & Multicellular Inputs, with Scott Earley and Madeline Nieves-Cintrón. Save the date for Washington DC, Aug 29–Sep 1. Registration details to follow very soon. Please circulate widely!

Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...

New publication Alert: Delighted to share our latest work. We describe a unique relationship between electrical and Calcium signaling; 'Electro-Calcium Coupling' in brain capillary endothelial cells. www.pnas.org/doi/10.1073/...

Congrats guys! Looking sharp also

Harry Pritchard@harry-pritchard.bsky.social · 2y ago

Last week we had the honour and surprise of winning the BHF Research Story of the Year award. The award was based off our work published last year, and was only possible due to an amazing group of scientist at the University of Manchester and the Geoffrey Jefferson Brain Research Centre.

I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...

Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...

www.biorxiv.org/content/10.1...

L-Type Ca2+ channels and TRPC3 channels shape brain pericyte Ca2+ signaling and hemodynamics throughout the arteriole to capillary network in vivo

Pericytes play a crucial role in regulating cerebral blood flow (CBF) through processes like vasomotion and neurovascular coupling (NVC). Recent work has identified different pericyte types at distinc...

biorxiv.org