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Amreen Mughal

@amreenmughal.bsky.social

PI @NINDS @NHLBI, Stadtman Tenure-track. 2024 NIH Distinguished Scholar. Interested in cerebral blood flow, neurovascular physiology, ion channels, in vivo microscopy, AD/ADRD, VCID.

24 Posts598 Follower478 Folgt
Tom Longden@talongden.bsky.social · 2w ago

Thrilled to be co-organizing the 2027 FASEB Science Research Conference on Vasoregulation: Signaling & Multicellular Inputs, with Scott Earley and Madeline Nieves-Cintrón. Save the date for Washington DC, Aug 29–Sep 1. Registration details to follow very soon. Please circulate widely!

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Ariel Levine@ariellevine.bsky.social · 3mo ago

Posting for Vibhu Sahni: Due to unforeseen circumstances the Burke Neurological Institute will have to terminate its research operations 5/22. There are international postdocs on visas who are looking for new homes. Please reach out to Vibhu if you can help

Amreen Mughal@amreenmughal.bsky.social · 9mo ago

First Preprint from my group @NIHIRP, where a summer project led by Vanshika Chaddha took unexpected turn into identifying Primary Cilia across the Brain Vasculature. New avenues for NVC. Amazing Collaboration with @sorengrubb.bsky.social, Carolyn Ott and Jennifer Lippincott-Schwartz.

Søren Grubb@sorengrubb.bsky.social · 9mo ago

New on bioRxiv! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 www.biorxiv.org/content/10.1... 🧪 🧵1/8

Angela Ballesteros@angelative.bsky.social · last yr.

Excited to share our first pre-print from the new SSPB section at the NIDCD!🥳 We hope you find it interesting and inspiring for future research. Thanks to our team, colleagues, mentors and collaborators 🔥 💪 🙏 . Take a look—and stay tuned for more! www.biorxiv.org/content/10.1...

TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells

TMC1 and TMC2, the pore-forming subunits of the mechanoelectrical transduction (MET) complex in inner ear sensory hair cells, are essential for auditory and vestibular function. Pathogenic mutations in TMC1 are a leading cause of genetic hearing loss, but their underlying cellular mechanisms remain poorly understood. Here, we reveal that TMC1 and TMC2 are cholesterol-regulated lipid scramblases whose activity modulates plasma membrane asymmetry. Using reconstituted proteoliposomes and molecular dynamics simulations, we demonstrate that both proteins facilitate phospholipid translocation across membrane bilayers, a process tuned by cholesterol and enhanced by deafness-causing TMC1 mutations. We show that this scramblase activity correlates with TMC1-dependent externalization of phosphatidylserine and membrane blebbing in murine auditory hair cells, linking TMC1-dependent membrane homeostasis dysregulation to auditory sensory cell pathology. These findings identify TMCs as a novel family of lipid scramblases, advancing our understanding of MET complex biology and offering mechanistic insight into membrane-driven forms of hereditary deafness. ### Competing Interest Statement The authors have declared no competing interest. National Institute on Deafness and Other Communication Disorders, https://ror.org/04mhx6838, DC000096, DC015271

biorxiv.org

Justin Bollinger@bollinger.bsky.social · last yr.

I am actively looking for a research scientist position or research administration role within the Raleigh-Durham (RDU) area! Please reach out if my background and skillset might fit your labs needs :-) Lots of experience with preclinical models, translational neuroscience, and behavioral analyses!