Review article with Omer Dushek @tcell.bsky.social on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton www.annualreviews.org/content/jour...

A new study from the @tcell.bsky.social lab demonstrates a novel strategy to reduce dangerous off-target effects in engineered T cell therapies. Find out more: www.path.ox.ac.uk/news-article...

Rewiring T cell co-receptors to improve the safety of cancer immunotherapy - Dunn School

A new study from the Dushek and van der Merwe labs demonstrates a novel strategy to reduce dangerous off-target effects in engineered T cell therapies.

path.ox.ac.uk

🚀 Our new Publication in Nature Biomedical Engineering!🎉 📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors 🔗 Read the full paper here: www.nature.com/articles/s41...

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors - Nature Biomedical Engineering

This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...

nature.com

Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal. Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens www.embopress.org/doi/full/10....

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens | The EMBO Journal

imageimageThe OT-I mouse T-cell receptor (TCR) is thought to perfectly discriminate between lower-affinity self- and higher-affinity foreign antigen-MHC complexes. This study shows OT-I TCR to exhibit imperfect discrimination and to be activated ...

embopress.org

The EMBO Journal@embojournal.org · 9mo ago

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses www.embopress.org/doi/full/10....

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses www.embopress.org/doi/full/10....

UK NK 2026 in Cardiff. January 9th. Be there. eventbrite.co.uk/e/uk-nk-confer… Hosted by Rich Stanton, Ceri Fielding & Eddie Wang

I was Chair of @biologists.bsky.social when we started this initiative, the brainwave of the @stevenkelly.bsky.social It was an imaginative idea and I am thrilled to see this landmark Remember: @biologists.bsky.social are the goodies in scientific publishing!

The Company of Biologists@biologists.bsky.social · 11mo ago

In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers. There are now over 10,000 trees for peer reviews! Thank you to all our peer reviewers. Find out more: forest.biologists.com #PRW2025 @peerreviewweek.bsky.social

We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference! www.biorxiv.org/content/10.1...

If you're a postdoc interested in starting your own group, please consider the Dunn School at Oxford, UK. It's a fantastic department and university for molecular immunology and all aspects of immune research!

The Dunn School, Oxford@dunnschool.bsky.social · last yr.

📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share! www.path.ox.ac.uk/work-with-us...

Temporal control of cytokine production is lost in 2nd-gen CAR-T cells, says Patel et al. This could be key to understanding their efficacy and toxicity in cancer immunotherapy. 🧬 🔗 https://bit.ly/4lOLicw #CancerImmunotherapy

Our new review article led by Jordan Kramer: Platforms for studying cell–cell recognition by immune cells onlinelibrary.wiley.com/doi/10.1111/...

📢 Registration is open for the Biomembrane Days 2025! 🔗 biomembrane-days-2025.mpikg.mpg.de A top-notch lineup of speakers, 120 posters, 200 scientists. 📜Submit an abstract by July 14 🏆3 Poster prizes ⚠️Limited spots-previous events were fully booked! #BiomembraneDays2025 #Biophysics #CellMembranes

CombiCells allow combinatorial display of cell surface ligands www.nature.com/articles/s41... A new Tools of the Trade article from Nature Reviews Immunology by Sofía Bustamante Eguiguren in our lab highlights the CombiCell platform to combinatorially display and titrate many cell surface ligands

The molecular reach of antibodies crucially underpins their viral neutralisation capacity Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts: www.nature.com/collections/...

Microbiology and infectious diseases

This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...

nature.com

Omer Dushek@tcell.bsky.social · 2y ago

Our work led by Anna Huhn is now published! The molecular reach of antibodies crucially underpins their viral neutralisation capacity lnkd.in/epe8YZPm Thank you to the reviewers for constructive feedback!

A fantastic EACR conference that focuses on all aspects of immune responses to cancer! Barcelona - May 2025

EACR - European Association for Cancer Research@helloeacr.bsky.social · last yr.

There's a month left for you to submit an abstract or apply for a Travel Grant to attend the next edition of Defence is the Best Attack, taking place in Barcelona in May! ☀️ Join us for an overview of the most recent advances in the field of immunotherapy: eacr.org/conference/d...

🚨New paper alert! 🚨 Our latest work in @cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/arti...

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

sciencedirect.com

📢 LAST CHANCE to submit your abstracts for BSI Oxford and @immunologyoxford.bsky.social's #OIS25 Symposium This is your opportunity to take part in this celebration Oxford's outstanding #immunology research 🔬 Submissions are open until midnight on Friday 7th Feb 👉 bit.ly/4elJmnG

📢 Abstract submission for BSI Oxford and @immunologyoxford.bsky.social 's #OIS25 Symposium closes NEXT WEEK (7 Feb) Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫 Submit your abstract here 👉 bit.ly/4elJmnG

Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.

How to Apply and Funding

iles.web.ox.ac.uk

We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...

The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!

Omer Dushek@tcell.bsky.social · 2y ago

Our new work! The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination www.biorxiv.org/content/10.1...

Our new work! The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination www.biorxiv.org/content/10.1...

A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology! Read the paper here: www.biorxiv.org/content/10.1... Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...

Our new work on optimising CAR-T cell sensitivity is now on bioRxiv! Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes biorxiv.org/cgi/content/...

🧵 My former office mate and esteemed colleague Anna Huhn has co-authored a groundbreaking study in @naturecomms.bsky.social. 🦠 We're talking viruses and antibodies! 1/5

Our work led by Anna Huhn is now published! The molecular reach of antibodies crucially underpins their viral neutralisation capacity lnkd.in/epe8YZPm Thank you to the reviewers for constructive feedback!

The molecular reach of antibodies crucially underpins their viral neutralization capacity www.nature.com/articles/s41... @naturecomms.bsky.social @tcell.bsky.social

Pre-print time! This time our lab tackled the enigmatic "autoinflammation of unknown origin". This is a cluster of rare patients with #autoinflammatory disease, which don't fit the criteria of other syndromes. It's not even clear its a single #disease, to be honest www.biorxiv.org/content/10.1...

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

Rod Rahimi@rodrahimi.bsky.social · 2y ago

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS

📢 Only few more days left to submit an abstract for #INTERPHACE2025 at @thecrick.bsky.social or get an early-bird ticket! - deadline 13th Dec! Don't miss out on presenting your work in an interdisciplinary environment, network, or maybe even find new collaborators? tinyurl.com/5n94xcuw