Delighted to host @pseudokinase.bsky.social at @cmri.bsky.social today for seminar. Join us at noon for what promises to be a fantastic talk: “The Living Dead – using integrative biology to define how the zombie proteins, MLKL and IRAK2, operate in innate immunity”

Registration open for the @garvaninstitute.bsky.social Signalling Symposium. linktr.ee/garvansignal...

A brilliant editorial by @mafdawson.bsky.social and @hilliardlab.bsky.social highlighting frustrations many Australian scientists feel about the decline of peer review standards for NHMRC funding. I wholeheartedly agree. www.science.org/doi/10.1126/...

Australia’s erosion of peer review

Throughout the world, peer review serves as the cornerstone of the scientific enterprise, providing rigorous quality control and building the confidence that underpins progress for both science and so...

science.org

@zeiss-microscopy.bsky.social Cell Discoverer 7 now up and running @cmri.bsky.social.

“T-loop Dynamics: Telomere Structure Shapes Cell Fate Decisions” is out now in @cp-trendscellbio.bsky.social . www.cell.com/trends/cell-... It was a pleasure to work on this with collaborator and friend @makotothayashi.bsky.social, whose insight was central to shaping the ideas in this review.

T-loop dynamics: telomere structure shapes cell fate decisions

Telomeres are nucleoprotein elements bound by shelterin that protect chromosome ends from DNA damage signalling and inappropriate repair. A defining architectural feature is the telomere loop (t-loop)...

cell.com

An important seasonal installation in the Cesare lab. March Madness bracket is up. Go Tar Heels! 🏀

@lisannes.bsky.social gave an outstanding seminar at @cmri.bsky.social yesterday. Full room, exciting data, and a 15-minute Q&A -- a fantastic discussion. Amazing work, Lisanne. Thank you for visiting and sharing it with the institute.

Delighted to host @cellpress.bsky.social editor Ilaria Carnevale today at @cmri.bsky.social for a seminar and meetings with our trainees and lab heads. Ilaria was Lead Editor at @cp-trendscellbio.bsky.social and now leads Trends Open. Welcome to Australia, Ilaria. Thank you for visiting CMRI.

2026 @cmri.bsky.social seminar series starts today! 12:00 pm: Angelica Lau, Program Manager (Health), Cicada Innovations. www.cicadainnovations.com Angelica will share how Cicada, Australia’s leading deep-tech incubator, supports researchers in translating lab discoveries into real-world impact.

1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: “A mechanistic approach to developing precision therapies for ALT-dependent cancers.” www.nhmrc.gov.au/funding/find...

If I may be allowed a moment of fatherly pride. Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺 A big achievement, especially in her first year of eligibility. Baseball is awesome.

1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate. This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au

Children's Medical Research Institute@cmri.bsky.social · 8mo ago

We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants Tony Cesare

We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants Tony Cesare

New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase". Happy our lab could play a small part. Congrats Tracy, Ash Harman, Noa Lamm and the whole team. www.nature.com/articles/s41...

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications

Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...

nature.com

One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.

Children's Medical Research Institute@cmri.bsky.social · 9mo ago

Huge congratulations to Professor Tony Cesare, winner of the University of Sydney’s 2025 Makers and Shapers Award for Outstanding Research. @sydney.edu.au @thecesarelab.bsky.social

Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25. Exciting science at a fantastic venue!

Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25. www.fusion-conferences.com/conference/188

The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability www.biorxiv.org/content/10.1... Delighted our lab could play a role supporting Noa’s vision on this project.

Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week. I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells

The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne. australiancellcycle.org A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting. We're looking forward to 2027!

Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social. Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.

Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness". If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!

Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.

Sandra Segura-Bayona@ssegurabayona.bsky.social · 11mo ago

🚀 New preprint alert! We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis. 📄 Read the manuscript here: www.biorxiv.org/content/10.1...

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4

A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!

Children's Medical Research Institute@cmri.bsky.social · last yr.

We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.

We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.

Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company. www.huntermeeting.org.au

Hunter Meeting 2025

huntermeeting.org.au

If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday. Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress. www.ozsinglecell.com