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Thomas Boettcher

@thomasboettcher.bsky.social

Professor of Microbial Biochemistry at University of Vienna at the Faculty of Chemistry and CeMESS. Investigating microbial metabolites and modulating bacterial behavior. #ChemicalBiology #Phages #Antibiotics https://boettcher-lab.univie.ac.at/

24 Posts152 Follower158 Folgt
Thomas Boettcher@thomasboettcher.bsky.social · 2w ago

Österreich sollte nicht die gleichen Fehler wie Deutschland mit den unsäglichen #WissZeitVG Reformen machen, welche die Situation für alle Beteiligten nur massiv verschlechtert haben. Wir brauchen Flexibilität, um die besten Köpfe gewinnen und halten zu können. @univie.ac.at orf.at/stories/3434...

Unis: Holzleitner will Teilzeitstudium

Wissenschaftsministerin Eva-Maria Holzleitner (SPÖ) plant die Einführung von Wissenschaftsregionen und die Möglichkeit, ein Studium in Teilzeit zu absolvieren. Parallelangebote am gleichen Standort so...

orf.at

Thomas Boettcher@thomasboettcher.bsky.social · 7mo ago

Proud to see our work on bacteriophage inhibitors featured on one of the covers of the first issue of this year of @rscchembio.rsc.org

RSC Chemical Biology@rscchembio.rsc.org · 7mo ago

First issue of 2026 is now online and #openaccess! In this issue: G-clamp based RNA-binding molecular probes, bacteriophage small molecule inhibitors, translation-enhancing peptide screening platforms, bioluminescent D-luciferin analogues and much more! 📰Read the full issue here: lnkd.in/eYSvHxtp

Front cover of RSC Chemical Biology Issue 1: a large pill-shaped orange structure on a purple background with smaller brown pill-like structures around the outside of the image, and three blue molecular structures in the foreground.
Thomas Boettcher@thomasboettcher.bsky.social · 8mo ago

www.linkedin.com/feed/update/...

We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological… | Thomas...

We have two chemical biology PhD positions within the CRC 1756 at the University of Vienna to be filled by April 2026. We are mainly looking for chemists with a strong interest in biological questions...

linkedin.com

Thomas Boettcher@thomasboettcher.bsky.social · 9mo ago

We are excited to be part of the newly approved SFB contributing from @univie.ac.at to this wonderful collaborative research centre!

Universität Konstanz@uni-konstanz.de · 9mo ago

In der aktuellen Auswahlrunde hat die @dfg.de gleich zwei neue #UniKonstanz Sonderforschungsbereiche bewilligt. Die Forschungsteams werden sich intensiv mit Trigger-Signalen bei biologischen Zellen sowie mit „Stille“ und „Störung“ in der menschlichen Sprache beschäftigen: https://t1p.de/e1ksl

Thomas Boettcher@thomasboettcher.bsky.social · 9mo ago

Check out our latest work, which got just published in Chemical Science. The study about SOS-independent prophage induction was led by Dr. Magdalena Jancheva: pubs.rsc.org/en/content/a... @univie.ac.at #phages #chemicalbiology #FWF #ERC

A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress

We identified a prophage-selective induction in poly-lysogenic Staphylococcus aureus induced by certain phenazines, such as pyocyanin, produced by Pseudomonas aeruginosa. Using a focused library of ph...

pubs.rsc.org

WHO@who.int · 10mo ago

New WHO report finds 1 in 6 bacterial infections were resistant to antibiotic treatments. Data from over 100 countries warns that rising resistance to essential antibiotics poses a growing threat to global health. Read more 👉bit.ly/438Ta1u

The text reads: “Resistance to antibiotics is widespread and increasing, threatening treatment of common infections. 1 in 6 bacterial infections worldwide were resistant to antibiotics in 2023.”
Thomas Boettcher@thomasboettcher.bsky.social · 11mo ago

For our antimicrobial drug development efforts at the University of Vienna we are looking for input from physicians/clinicians who are familiar with treatment, diagnostics, infection control, etc. Your insights would be highly valuable! docs.google.com/forms/d/e/1F...

Survey on the clinical need for an ultra-narrow spectrum N. gonorrhoeae Antibiotic

Welcome and thank you for participating in this survey! We are the researchers in Boettcher's group at University of Vienna, who are developing the new antibiotic specifically targeting N. gonorrhoeae...

docs.google.com

Thomas Boettcher@thomasboettcher.bsky.social · last yr.

Good to read an informed scientific opinion on this topic. I couldn't agree more. Safety considerations for additives regardless whether synthetic or natural should be only based on scientific data and not on ideology or personal beliefs.

Andrea Love, PhD | Biomedical Scientist@drandrealove.bsky.social · last yr.

I couldn’t care less whether companies use synthetic or naturally-derived dyes — I have zero skin in the game. The issue? The war on “synthetic food dyes” isn’t about food dyes: It’s about letting uninformed opinions & misinformation undermine science, data, & public health. A thread 👇🏻 1/

Nature Microbiology@natmicrobiol.nature.com · last yr.

💊🦠OUT NOW - new research showing that 2-nonyl-4-quinolone N-oxide and its 3-methyl derivative kill Neisseria gonorrhoeae in vitro and significantly reduce bacterial numbers in vivo, in mouse infection models #MicroSky www.nature.com/articles/s41...

A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature Microbiology

Pseudomonas aeruginosa-derived 2-nonyl-4-quinolone N-oxide exerts bactericidal effects on Neisseria gonorrhoea via zeta1–epsilon1 toxin–antitoxin activation in vitro and abrogates experimental infecti...

nature.com

Thomas Boettcher@thomasboettcher.bsky.social · last yr.

Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social medienportal.univie.ac.at/en/media/rec...

New antibiotic for multidrug resistant superbug, that causes gonorrhoea

This novel antibiotic activates an existing "suicide" mechanism in gonococci

medienportal.univie.ac.at

Universität Wien / University of Vienna@univie.ac.at · last yr.

Die Zunahme von antibiotikaresistenten Keimen ist ein wachsendes Problem. Dazu gehört etwa der Problemkeim Neisseria gonorrhoeae, der Tripper (Gonorrhö) auslöst. Forscher*innen der Universitäten Konstanz und Wien entdeckten nun eine neue Klasse von Antibiotika, die selektiv dagegen wirken. 💊

Neues Antibiotikum gegen Problemkeim, der Tripper (Gonorrhö) auslöst

Neuartiges Antibiotikum aktiviert einen in den Gonokokken bereits vorhandenen Selbsttötungsmechanismus

medienportal.univie.ac.at

Antimicrobial resistance #AMR@antimicrobial.bsky.social · last yr.

Precision medicine for #AMR is making real progress. BiomX's BX211 phage therapy for diabetic foot osteomyelitis (S. aureus) just hit a major milestone in Phase II. Significant ulcer reduction over 91 days. #PhageTherapy #Biotech #InfectiousDisease www.insideprecisionmedicine.com/topics/preci...

91 Days Later: BiomX’s Phage Fights Off Diabetic Bone Infection in Phase II

CEO Jonathan Solomon explains the significance of BX211—a phage therapy for diabetic foot osteomyelitis—in developing a new precision medicine modality.

insideprecisionmedicine.com

Thomas Boettcher@thomasboettcher.bsky.social · last yr.

Just out now: wonderful work from our lab by lead author Viktoriia Savchenko expanding our knowledge of the diversity of bacteria involved in quinolone biosynthesis, with a newcomer to the family of quinolone producers. #CoE7 @univie.ac.at @cemess.bsky.social #ChemBio pubs.acs.org/doi/10.1021/...

Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers

2-Alkyl-4(1H)-quinolones play a key role in bacterial communication, regulating biofilm formation, and virulence. Their antimicrobial properties also support bacterial survival and interspecies competition in microbial communities. In addition to the human pathogen Pseudomonas aeruginosa various species of Burkholderia and Pseudoalteromonas are known to produce 2-alkyl-4(1H)-quinolones. However, the evolutionary relationships of their biosynthetic gene clusters remain largely unexplored. To address this, we investigated the phylogeny of 2-alkyl-4(1H)-quinolone biosynthetic gene clusters, leading to the discovery of Chitinivorax as a fourth genus capable of producing 2-alkyl-4(1H)-quinolones, expanding our knowledge of the diversity of bacteria involved in quinolone-biosynthesis.

pubs.acs.org