New paper out in Biophys J @biophysicalsoc.bsky.social: upon heating, instead of expanding as folded structures, we found that unstructured RNAs (such as polyA in mRNA tails) undergo slight collapse. We traced it to the strengthened ion-RNA interactions at high temps. www.cell.com/biophysj/abs...

Temperature-dependent ion migration underlies sequence-specific collapse of unstructured RNA

Ions and temperature jointly regulate RNA structure, dynamics, and phase behavior, yet their coupled effects remain poorly understood at the molecular level. Single-stranded RNA (ssRNA), a ubiquitous ...

cell.com

Excited to share our latest work on poly(ADP-ribose) (PAR), an underexplored nucleic acid essential for DNA damage repair. We show that PAR is structurally distinct from RNA/DNA and exhibits unique ion-dependent properties. @tienhungf91.bsky.social @narjournal.bsky.social 📄 doi.org/10.1093/nar/...

very happy that our first foray out of the world of proteins and nucleic acids just appeared on NAR. We develop a coarse-grained model for poly(ADP-ribose) (PAR, a close cousin of RNA that plays important role in DNA damage response). academic.oup.com/nar/article/...

My lab is looking for 1-2 PhD students for Fall 2026 to develop coarse-grained and statistical mechanical models to study RNA folding, ion–RNA interactions, and biomolecular phase separation. Join us for a virtual session, register here buffalo.zoom.us/meeting/regi... @ubuffalo.bsky.social

Excited to have this work published. With @trceklab.bsky.social we show that RNA structure impedes intermolecular base pairing in germ granule.

Trcek Lab@trceklab.bsky.social · 11mo ago

New paper from the Trcek lab, with Siran Tian as the lead author - congratulations Siran!: www.nature.com/articles/s41...

Ecstatic to have our lab's first paper published on JPCL @pubs.acs.org. We showed the ion atmospheres of unstructured RNAs extend farther into solution compared to folded structures. pubs.acs.org/doi/10.1021/...

RNA Structural Complexity Dictates Its Ion Atmosphere

Electrostatic interactions mediated by surrounding ions critically influence RNA behavior, yet flexible RNAs remain underexplored. We performed molecular dynamics simulations to examine three RNAs acr...

pubs.acs.org

🚨 We’re looking for a curious mind to join our lab at the NIH! Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging? Interested in a postdoc or a PhD research visit at NIH? Let’s connect. 📩 DM or email for details! #Bioinformatics #AI #ComputationalBiology

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

Excited to share our lab's preprint! We found that flexible RNAs have much broadened ion atmospheres than structured RNAs. This leads us to speculate the implications on molecular recognition and phase behavior. Please check full text for other interesting details www.biorxiv.org/content/10.1...

RNA structural complexity dictates its ion atmosphere

Electrostatic interactions mediated by the surrounding ions govern virtually every facet of RNA behavior. Most studies have focused on rigid, well-folded motifs, leaving the structurally heteregeneous...

biorxiv.org

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

the word alert is in a purple circle

ALT: the word alert is in a purple circle

media.tenor.com

More from the Washington Post (and this one is a doozy) regarding the President's Budget. Note that this is an aspirational document and Congress has to act (or ignore it). [Gift Link] wapo.st/42gLz0Z 1/n

Internal budget document reveals extent of Trump’s proposed health cuts

HHS would be asked to absorb a $40 billion cut, about one-third of its discretionary budget.

wapo.st

We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social

Text might be tiny, but here's the existing 27 vs. the proposed 15 institutes that will be left standing. You'll probably see a number of resignations, re-assignments, and the whole thing will be administered by political appointees who will oversee funding & policy.

Confirmation!! And including open sessions!

Jeremy Berg@jeremymberg.bsky.social · last yr.

I now have multiple sources that say at least one round of NATIONAL ADVISORY COUNCIL MEETINGS will now be announced in the Federal Register.