First PROTAC gains FDA approval, bolstering targeted protein degradation and induced proximity ambitions www.nature.com/articles/d41...

Excited to share a new paper from our lab! Reversible control of γ-globin by LRF provides new insight relevant to HbF reactivation strategies. Congratulations, Manaka! www.sciencedirect.com/science/arti...

Excited to share our new paper in Blood (@bloodjournals.hematology.org), where we explore how XPO7 (Exportin 7) and histone gene regulation intersect with p53 functional status in AML. Congrats to Yuichiro and the team! ashpublications.org/blood/articl...

very intersting work!

Johannes Zuber@johanneszuber.bsky.social · 10mo ago

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

An mRNA Crime | Science | AAAS www.science.org/content/blog...

An mRNA Crime

science.org

A beautiful review by Stu Orkin—a true giant in transcriptional regulation, hematopoiesis, and sickle cell research!

NEJM.org@nejm.org · last yr.

Franklin H. Epstein Lecture: The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for mutant β-globin. Learn more in a new review: nej.md/455rPiJ #MedSky

Mutations that stick: Unexpected discovery of molecular glue mimicry

Mutations that stick: Unexpected discovery of molecular glue mimicry

Recent elegant studies in Nature uncovered an unprecedented molecular glue-like mechanism of action for the preclinical drug UM171. This small molecule showed striking functional and structural similarities to brain-cancer mutations that prompt neomorphic protein interactions. This phenomenon of chemical-genetic convergence could be reverse-engineered to aid the rational design of induced proximity therapeutics.

dlvr.it

A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...

Healing My Family’s Future

How genetics and IVF empowered a family to leave cancer behind.

press.asimov.com

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support: grants.nih.gov/grants/guide...

A miniaturized #CRISPR system can edit DNA in monkey muscle, according to a new preprint.

A new ‘mini-CRISPR' flexes its editing power in monkey muscles

The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases

scim.ag

So proud of @katie-maurer.bsky.social and Cameron Park for showing the power of combining innovative #ML with what we call "Katie Intelligence" (our domain expert in the loop 👩‍🔬) for building impactful computational tools and applying them to obtain unexpected clinical insight!

Katie Maurer@katie-maurer.bsky.social · 2y ago

Excited to share our work on cytotoxic CD8+ T cells in donor lymphocyte infusions for treatment of AML relapsed after HSCT, out today in @sciimmunology.bsky.social! Great working with @elhamazizi.bsky.social on this exciting area! www.science.org/doi/10.1126/...

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below! go.bsky.app/EY3k2bE