Haley Lab

@labohaley.bsky.social

We develop and apply advanced genetic manipulation technologies to make sense of biological complexity. Formerly @Genentech now @umontreal.ca. More about our lab and research here: labohaley.com

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · last mo.

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481

Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Beyond excited to share our latest publication in Nature Portfolio/Nature Communications, where we aimed to overcome barriers that have thus far prevented widespread application of Cas12a — Cas9’s highly versatile cousin — for single-cell screening applications. www.nature.com/articles/s41...

A tunable Cas12a platform for single-cell perturbation screening and CRISPRi - Nature Communications

Cas12a self-processing of guide RNA transcripts limits its use for Perturb-seq by preventing guide capture. Here, authors develop a chemically degradable Cas12a platform enabling accurate guide assign...

nature.com

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

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I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

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We’re hiring! @jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community! Details below👇

The Company of Biologists@biologists.bsky.social · 8mo ago

Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb. More at: www.biologists.com/about-us/wor...